Heterogeneity of hypoxia in solid tumours and mechanochemical reactions with oxygen nanobubbles

Orel, Valerii B.; Zabolotny, M. A.; Orel, Valeriy E.

doi:10.1016/j.mehy.2017.03.006

Cited by 24 publications

(14 citation statements)

References 34 publications

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“…Usually, the great structural and functional abnormalities of tumor microcirculation caused spatial and temporal heterogeneity in its perfusion, as well as regional heterogeneity of hypoxia. [ 19 ] In addition, the treatment alleviated the vascular pressure and further facilitated oxygen infusion in tumor site, which relieved the tumoral hypoxic environment. Therefore, the oxygen infusion was in a dynamic situation, and the GOD‐catalyzed glucose oxidation might be available in tumor treatment.…”

Section: Resultsmentioning

confidence: 99%

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Shao

Wang

Hao

et al. 2021

Adv Healthcare Materials

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The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, developing cascade catalytic nanoplatforms by fully making use of substances in TME for cancer therapy may deserve full credit. Herein, a cascade catalytic nanoplatform based on glucose oxidase (GOD) modified mesoporous iron oxide nanoparticles (IONP) loaded with Artemisinin (ART) is developed, which is designed as IONP-GOD@ART. GOD can catalyze the oxidization of glucose into gluconic acid and H 2 O 2 , which not only realizes tumor starvation therapy, but also provides H 2 O 2 for IONP mediated Fenton reaction. Simultaneously, mesoporous IONP releases Fe 2+ and Fe 3+ ions in acidic TME. On the one hand, iron ions undergo Fenton reaction to generate hydroxyl radicals for chemodynamic therapy. On the other hand, the endoperoxide bridge in ART is broken in presence of Fe 2+ and further generates reactive oxygen species (ROS) to achieve therapeutic purpose. In this sense, IONP-GOD@ART manipulates TME characteristics and leads to "butterfly effect", which brings out a large amount of ROS for eliciting immunogenic cell death, inducing M1-TAMs polarization, and further reprogramming immunosuppressive TME for enhanced immunotherapy. By this delicate design, the cascade catalytic nanoplatform of IONP-GOD@ART realizes potent cancer immunotherapy for tumor regression and metastasis prevention.

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Section: Resultsmentioning

confidence: 99%

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Shao

Wang

Hao

et al. 2021

Adv Healthcare Materials

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“…(1) Structural and functional inferiority of tumor vessels leading to the deterioration of oxygen diffusion through their walls [21][22][23][24][25][26] (2) Heterogeneity of tumor vessels in origin, morphology, degree of maturity, and sensitivity to drugs [27][28][29][30][31][32] Given these two points, it is logical to assume that the qualitative and quantitative features of tumor vessels can directly affect the severity of hypoxia in tumors, the prognosis of disease, and the sensitivity of the tumor to chemotherapy and radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Сеньчукова

Макарова

Shurygina

et al. 2020

Journal of Oncology

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The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics. Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer. The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer. A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated. Samples were stained with Mayer hematoxylin and immunohistochemically using antibodies to CD34, podoplanin, HIF-1a, and Snail. The eight types of tumor MVs differed in morphology were identified. It was established that only the dilated capillaries (DСs) with weak expression of CD34, the contact type DCs, the capillaries in tumor solid component, and the lymphatic vessels in the lymphoid and polymorphic cell infiltrates of tumor stroma are associated with clinical and pathological characteristics of early cervical cancer. Preliminary results also suggest that a combination of fragmentation in tumor solid component and the contact type DCs may predict a recurrence of early cervical cancer. Given the small number of cervical cancer recurrences, the predictive significance of the described markers requires a more thorough examination.

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“…Additionally, hypoxia is a key feature of the solid tumor microenvironment ( 3 ). It is well known that hypoxic tumor microenvironments are associated with a higher invasive ability and the occurrence of distal metastases, that they can increase the resistance of tumor cells to chemotherapy, and may result in reduced chemotherapeutic efficacy ( 4 , 5 ). Therefore, tumor chemoresistance under hypoxic microenvironments has become a popular research topic.…”

Section: Introductionmentioning

confidence: 99%

“…Our previous study preliminarily measured the tumor PO 2 in mice transplanted with human breast cancer cells using the EPR technique, and validated hypoxia as a characteristic of breast cancer tumors in animal models. Hypoxia within the tumor microenvironment is an important factor in chemotherapy resistance ( 4 , 5 ). Therefore, measurement of the dynamic changes of the PO 2 during tumor physiology and treatment using the EPR technique may provide scientific evidence for identifying the oxygen-enriched environment and selecting an optimal time window for treatment.…”

Section: Introductionmentioning

confidence: 99%

PO2‑based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy

Cai

2018

Oncol Lett

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The partial pressure of oxygen (PO2) in the tumor microenvironment directly affects tumor sensitivity to chemotherapy. In the present study, a lithium phthalocyanine probe was implanted into MCF-7 human breast cancer cells, followed by transplant of the cells into nude mice. The present study used an electron paramagnetic resonance (EPR) oximetry measuring technique to dynamically monitor PO2 in the tumor microenvironment prior to and following chemotherapy, and aimed to determine the precise time window in which the microenvironmental PO2 peaked following chemotherapy. The results indicated that PO2 was significantly higher in breast cancer compared with control (P<0.05). Following four cycles of chemotherapy, the activity of NADH dehydrogenase, succinate-cytochrome c reductase and cytochrome c oxidase in the mitochondria of cells was significantly reduced when compared with their activity prior to chemotherapy (P<0.05). Regional blood flow in tumor tissues undergoing chemotherapy was significantly lower than that prior to chemotherapy (P<0.05). The rate of cellular apoptosis in the PO2 peak-based chemotherapy group was significantly greater than that in the conventional chemotherapy group after two and four cycles of chemotherapy (P<0.05). Tumor volume in the PO2 peak-based chemotherapy group was significantly reduced compared with that in the 0.9% NaCl solution control and the conventional chemotherapy groups after four cycles of chemotherapy (P<0.05). The tumor inhibitory rate of the experimental group was significantly higher than that of the conventional chemotherapy group (P<0.01). In conclusion, the present study may provide guidance for the development of effective strategies depending on tumor-maximal response to chemotherapy in an oxygen-rich environment. Additionally, the present study aimed to establish a foundation for a clinical noninvasive assessment intended to guide treatment and formulate individual regimens, in order to improve cancer therapeutics, sensitivity monitoring and curative effect estimation.

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Heterogeneity of hypoxia in solid tumours and mechanochemical reactions with oxygen nanobubbles

Cited by 24 publications

References 34 publications

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

PO2‑based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy

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