High Molecular Weight Coffee Melanoidins Are Inhibitors for Matrix Metalloproteases

Marco, Leticia Missagia de; Fischer, Sarah; Henle, Thomas

doi:10.1021/jf202778w

Cited by 34 publications

(26 citation statements)

References 45 publications

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“…Melanoidins, which are nitrogen-containing products, are potent and selective inhibitors of the human zinc-containing endopeptidases MMP-1, MMP-2 and MMP-9, but are ineffective against ACE (angiotensin I-converting enzyme) and ChC (Clostridium histolyticum collagenase). This finding suggests that while melanoidins are known as zinc chelating agents, they specifically block the MMP active pocket (De Marco et al 2011).…”

Section: Invasion and Metastasis Inhibitorsmentioning

confidence: 93%

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

2015

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Coffee is the second most popular beverage in the world after water with a consumption of approximately two billion cups per day. Due to its low cost and ease of preparation, it is consumed in almost all countries and by all social classes of the population through different modes of preparation. Despites its simple appearance, a cup of coffee is in fact a complex mixture that contains hundreds of molecules, the composition and concentration of which vary widely and depend on factors including the origin of the coffee tree or its metabolism. Although an excessive consumption of coffee can be harmful, many molecules that are present in this black decoction exert anticancer properties. This review aims to describe the different primary coffee-containing substances that exert chemopreventive and bioactive activities against the different hallmarks and enabling characteristics of cancer, thus explaining the anticancer health benefit of black coffee.

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Section: Invasion and Metastasis Inhibitorsmentioning

confidence: 93%

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

2015

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“…Furanones, pyranones, and cyclopentenones isolated from model reactions and identified as chromophoric precursors for the formation of melanoidins functioned as inhibitors of the growth of tumor cells in vitro in micromolar concentrations, possibly through inhibition of the phosphorylation of the transcription factor Elk‐1 220. 221 Coffee melanodins in physiologically relevant concentrations are efficient inhibitors of certain matrix metalloproteinases, to which a central role in the pathogenicity of colorectal cancers is accredited 222…”

Section: Outlook: Maillard Reaction—quo Vadis?mentioning

confidence: 99%

Baking, Ageing, Diabetes: A Short History of the Maillard Reaction

2014

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The reaction of reducing carbohydrates with amino compounds described in 1912 by Louis-Camille Maillard is responsible for the aroma, taste, and appearance of thermally processed food. The discovery that non-enzymatic conversions also occur in organisms led to intensive investigation of the pathophysiological significance of the Maillard reaction in diabetes and ageing processes. Dietary Maillard products are discussed as "glycotoxins" and thus as a nutritional risk, but also increasingly with regard to positive effects in the human body. In this Review we give an overview of the most important discoveries in Maillard research since it was first described and show that the complex reaction, even after over one hundred years, has lost none of its interdisciplinary actuality.

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“…Inhibition of MMPs synthesis and activity could be an interesting approach for colon cancer therapy together with chemotherapeutic drugs (Zucker et al 2000). The potential inhibitory activity of coffee melanoidins against recombinant human MMPs was assayed by De Marco et al (2011). Water-soluble high molecular weight coffee melanoidins (extracted by ultrafiltration at 10 kDa cutoff) were able to inhibit MMPs with IC 50 value between 0.2 and 0.7 mg/mL.…”

Section: The Possible Role Of Food Melanoidins In the Protection Of Gmentioning

confidence: 99%

The gastro-intestinal tract as the major site of biological action of dietary melanoidins

Tagliazucchi

Bellesia

2015

Amino Acids

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Emerging evidence from laboratory researches has highlighted the bioactivity of food melanoidins and melanoproteins. Whilst such studies have been carried out with different in vitro systems, information about melanoidins absorption and bio-availability are scarce. However, they are generally considered as poorly absorbable and bio-available compounds. Therefore, we present a review in which the gastro-intestinal tract is hypothesized to be the main site of action of food melanoidins and melanoproteins biological activity. We described recent data supporting this hypothesis both in vitro model systems and in vivo. Importantly, we focused this review only on the effect of melanoidins and melanoproteins extracted from food. Most of the studies had been carried out using water-soluble carbohydrate-based melanoidins isolated from different food sources (beer, barley coffee, coffee). In bakery products, melanoidins are protein-based structure (melanoproteins) which are largely insoluble in water. Dietary melanoidins and melanoproteins have been demonstrated to exert in vitro antioxidant and metal chelating ability in the gastro-intestinal tract reducing the formation of lipid hydroperoxides and advanced lipid oxidation end products during the digestion of meat. The reduction in the formation of these pro-atherogenic compounds has been shown to be followed by a decrease in their absorption in human volunteers. Food melanoidins have also shown in vitro anti-caries and prebiotic activities. We conclude by underlining the possible role of food melanoidins in the prevention of gastro-intestinal tract cancers. We hope this review will stimulate further research on food melanoidins and their biological activities in the gastro-intestinal tract.

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High Molecular Weight Coffee Melanoidins Are Inhibitors for Matrix Metalloproteases

Cited by 34 publications

References 45 publications

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Baking, Ageing, Diabetes: A Short History of the Maillard Reaction

The gastro-intestinal tract as the major site of biological action of dietary melanoidins

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