High throughput method for prototyping three-dimensional, paper-based microfluidic devices

Lewis, Gregory G.; DiTucci, Matthew J.; Baker, Matthew S.; Phillips, Scott T.

doi:10.1039/c2lc40331e

Cited by 131 publications

(100 citation statements)

References 20 publications

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“…Fluid can move freely in both the horizontal and vertical directions in a 3D-μPAD. Yoon groups [108,109], Costa et al [110] and Lewis et al [111] fabricated 3D-μPADs by stacking alternating layers of patterned paper and double-sided adhesive tape with holes. In the presence of H 2 O 2 generated by GOx, the HRP converts 4-AAP and N -ethyl- N -(2-hydroxy-3-sulfopropyl)-3,5-dimethylaniline sodium salt monohydrate (MAOS) from colorless compounds to a blue form, which can be visualized in the detection zone.…”

Section: Colorimetric Detection Of Glucosementioning

confidence: 99%

A Review on Microfluidic Paper-Based Analytical Devices for Glucose Detection

Liu

2016

Sensors

116

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Glucose, as an essential substance directly involved in metabolic processes, is closely related to the occurrence of various diseases such as glucose metabolism disorders and islet cell carcinoma. Therefore, it is crucial to develop sensitive, accurate, rapid, and cost effective methods for frequent and convenient detections of glucose. Microfluidic Paper-based Analytical Devices (μPADs) not only satisfying the above requirements but also occupying the advantages of portability and minimal sample consumption, have exhibited great potential in the field of glucose detection. This article reviews and summarizes the most recent improvements in glucose detection in two aspects of colorimetric and electrochemical μPADs. The progressive techniques for fabricating channels on μPADs are also emphasized in this article. With the growth of diabetes and other glucose indication diseases in the underdeveloped and developing countries, low-cost and reliably commercial μPADs for glucose detection will be in unprecedentedly demand.

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Section: Colorimetric Detection Of Glucosementioning

confidence: 99%

A Review on Microfluidic Paper-Based Analytical Devices for Glucose Detection

Liu

2016

Sensors

116

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“…Clamping of the paper layers can be used to achieve this, 26 or alternatively, doublesided adhesive layers can be used to stick the layers together. 16 Lewis et al 30 also demonstrated that spray adhesive can efficiently seal these devices and ensure good contact between the device layers. This technique is simple to use, low-cost and enables high-throughput production.…”

Section: Volume 111 | Number 11/12mentioning

confidence: 99%

Paper-based smart microfluidics for education and low-cost diagnostics

Smith¹,

Moodley²,

Govender³

et al. 2015

S. Afr. J. Sci.

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Current centralised healthcare models pose many challenges, particularly for developing countries such as South Africa, where travel and time costs make it difficult for patients to seek healthcare, even when urgently needed. To address this issue, point-of-care (PoC) tests, which are performed at or near the site of clinical care, have gained popularity and are actively being developed. Microfluidic systems, in which small volumes of fluids can be processed, provide an ideal platform on which to develop PoC diagnostic solutions. Specifically, the emerging field of paper-based microfluidics, with advantages such as low-cost, disposability and minimal external equipment requirements, provides unique opportunities for addressing healthcare issues in developing countries. This work explores the field of paper-based microfluidics, with step-by-step instructions on the design, manufacture and testing processes to realise paper-based devices towards diagnostic applications. Paper-based microfluidic and electronic components are presented, as well as the integration of these components to provide smart paper-based devices. This serves as an educational tool, enabling both beginners and experts in the field to fast-track development of unique paper-based solutions towards PoC diagnostics, with emphasis on the South African context, where both the need for and impact of these solutions are great.

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“…While its foundations date back to the 1940s, the field of paperbased microfluidics has recently regained interest largely because paper is a very low cost material that has the intrinsic ability to pump fluids by capillary forces Dungchai et al, 2009;Fu et al, 2012;Hwang et al, 2011;Lewis et al, 2012;Martinez et al, 2010;Muller and Clegg, 1949;Nie et al, 2010). The ultimate goal of a paper-based microfluidic device is to offer pointof-care diagnostics at an unprecedented low price (≪ $1 per device) to achieve a widespread use in medicine.…”

Section: Introductionmentioning

confidence: 99%