Highly sensitive quartz crystal microbalance based biosensor using Au dendrite structure

Abstract

A Au dendrite structure was obtained by only electroplating under a suitable potential. A blanch like nanostructure was formed along the crystal orientation. In this study, we attempted to fabricate a Au dendrite structure on the electrode of a quartz crystal by electroplating to increase the specific surface area. We estimated the effective surface area by cyclic voltammetry (CV) and monitored the frequency shift induced by antigenantibody interaction by the quartz crystal microbalance (QCM) method. The dendrite structure with the largest surface area was formed under %0.95 V for 5 min. In the measurement of the antigen-antibody interaction, the frequency shifts of 40, 80, and 110 Hz were obtained with the dendrite structured QCM chips formed at the above potential for 1, 1.5, and 2.0 min, respectively. The sensitivity was improved compared with that QCM chip having a flat surface electrode.

Application of Shear Horizontal Surface Acoustic Wave (SH-SAW) Immunosensor in Point-of-Care Diagnosis

“…However, only a few products on the market are in use: TSM, BAW, and SH-SAW. Quartz crystal microbalance (QCM) has been widely used for a long time in a variety of different applications [ 13 , 14 , 15 ]. One of the successful commercial applications of QCM is an odor sensor [ 16 , 17 ].…”

Sensitive label-free immunoglobulin G detection using a MEMS quartz crystal microbalance biosensor with a 125 MHz wireless quartz resonator

“…Owing to advantages of high stability, simple instrumentation, label free, and capability of real-time monitoring, the quartz crystal resonator has been applied in a variety of areas, such as, frequency source of communication systems, 1 gas sensors, [2][3][4][5] biosensors, [6][7][8][9][10] and so on. Based on the mass loading effect, quartz crystal microbalance (QCM) coated with water-absorbing materials, including graphene oxides, 11 nanodiamond film, 12 TiO 2 , 13 SnO 2 nanowires, 14 and polydopamine/graphene oxide 15 have been developed as sensitive humidity sensors.…”

“…Owing to their advantages of high stability, simple instrumentation, label-free detection, and capacity for real-time monitoring, quartz crystal resonators have been applied in a variety of areas, for example, the frequency source of communication systems, 1) gas sensors [2][3][4][5] and biosensors. [6][7][8][9][10] Based on the mass loading effect, quartz crystal microbalances (QCMs) coated with water-absorbing materials, including graphene oxides, 11) nanodiamond film, 12) TiO 2 , 13) SnO 2 nanowires 14) and polydopamine/graphene oxide, 15) have been developed as sensitive humidity sensors. In addition, metal oxide nanofibrous membranes, 16) monolayer graphene films, 17) manganese oxide nanosheets 18) and carbon nanotubes 19) have been deposited on QCMs to fabricate sensors for the detection of volatile organic compounds.…”

A Study The Effect Of Coating Polystyrene, Znpc, And Annealing Process On The Resonant Frequency Of Quartz Crystal Microbalance

“…This sensor can detect mass changes on the surface allows measurement in the gas phase (Hori, 2020) and liquid phase (Liang, 2014) (Wu, 2019) . The small mass adsorbed on the electrode surface will lead to a QCM frequency decrease causes the magnitude for a frequency shifted (Asai, 2017) (Pan, 2019).…”