Histocompatibility Antigens and Other Genetic Markers in Ankylosing Spondylitis and Inflammatory Bowel Diseases

Abstract

SUMMARY Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81.4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset. In addition to B27, another HLA antigen may be associated with AS; the antigen Bw16 was found to be significantly increased in B27 negative AS patients. HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bowel disease (IBD). In fifty‐eight ulcerative colitis (UC) patients a raised incidence of A11 was noticed. In fifty‐one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty‐nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly different from the B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD an increased frequency of Bw16 was also shown.

Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease.

“…52 6% of the CD-AS patients were HLA B27 positive, which differed significantly from the frequency of HLA B27 in a group of CD patients without AS (3*9 %) studied separately (van den Berg- Loonen et al, 1977) CD-AS and 3 UC-AS patients had at some time in their illness a peripheral arthritis, and in 9 and 2, respectively, joint inflammation ran in parallel with inflammatory bowel activity. The large majority of both CD-AS and UC-AS patients showed a severe form of radiographic sacroiliitis (grade 3 or 4).…”

“…The frequency of HLA B27 in UC-AS patients was 66 -7 %. In comparison, UC patients without AS had a frequency of 19% (van den Berg-Loonen et al, 1977), but this was not significant. The frequency of HLA B27 in CD-AS and UC-AS patients differed significantly from the frequency of HLA B27 in a nonselected group of patients with idiopathic AS with no evidence of IBD (81.7%) (van den Berg-Loonen et al, 1977) (P<0-01 and P<0.01 respectively).…”

HLA Antigen Distribution and HLA Haplotype Segregation in Crohn's Disease

“…However, the difference did not reach statistical significance and the association with HLA-B17 has not been confirmed in other countries, including The Netherlands. Here, a group in Amsterdam (van den Berg-Loonen et al 1977) and our group in Leiden have found, independently of each other, an association with HLA-B18, but again the association is not impressive: 21.6% in patients and 6.9% in controls in Amsterdam and 12.1% in patients as against 6.5% in controls in Leiden.…”

HLA antigens in ulcerative colitis: a study in the Sicilian population

“…To date, the search for HLA markers in UC has been inconclusive (Kirsner & Shorter 1982). Several surveys did not find divergences from controls (Corazza et al 1978, Smolen et al 1982, whereas other authors found significant associations with different antigens in different populations (van den Berg-Loonen et al 1977, Delpre et al 1980, Schrumpf et al 1982. Recently, in a Japanese population, an association with B5, DR2 haplotype has been shown (Asakura et al 1982).…”