Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium

Abstract

Highlights The administration of nanoherbal andaliman reduced apoptosis via cytochrome c and FasL. EVOO reduces apoptosis via cytochrome c and FasL better than andaliman. Combination Nano herbal andaliman and EVOO reduce reduced apoptosis via cytochrome c and FasL on placental histology of hypertension rats. Combination Nano herbal andaliman and EVOO reduce MDA levels in hypertension rats. Nano herbal andaliman and combined with EVOO increase HSP-70 expression in hypertension rats.

Suppression of Fas expression in the hypertensive placental histology of rast given Nano herbal of Rhodomyrtus tomentosa leaves

“…The plant was classified and authenticated by the Head of Botany at the Universitas Sumatera Utara and deposited into the Medanense Botanical Herbarium (registration range 6675/MEDAN/2021). Nanoherbal R. tomentosa (NRT) was produced at the Indonesian Research Institute (LIPI) in Jakarta, Indonesia, by high-energy milling (HEM) (Ilyas et al, 2020;Situmorang et al, 2021a). LPS was intraperitoneally administered within 3 hours using Escherichia coli 026:B6 (1 mg/kg BW) dissolved in 0.9% NaCl.…”

“…The experimental animals were pregnant female Wistar rats that weighed 150-200 g, were 2 months old, and were in a healthy condition (Situmorang et al, 2021a). This research passed the animal ethics review from the Ethics Commission of the Faculty of Mathematics and Natural Sciences, USU (ethical clearance no.…”

“…Surgery: The rats were sedated with ketamine on the 19th day of pregnancy. Then, surgery was performed to obtain the blood, foetus, and placenta (Situmorang et al, 2021a).…”

Effect of sikkam (Bischofia javanica Blume) ethanolic extract on the quality and quantity of hyperglycemic rat sperm

“…A total of 1 kg of fresh B. javanica leaves were dried and then were obtained 270 g of ethanol extract of B. javanica leaves. The drying process was based on the methods used for drying Rhodomyrtus tomentosa and Zanthoxylum acanthopodium as described previously (Situmorang et al, 2019a;2019b;2021a;2021b;2021c), so that the phytochemical content in this herb was not lost due to heat.…”

Effects of Zanthoxylum acanthopodium on MMP-9 and GLUT-1 expression and histology changes in rats with cervical carcinoma

“…In addition, andaliman fruit can increase Hes1 and Notch1 gene expression in human trophoblasts in vitro (Situmorang et al 2021a). Zanthoxylum acanthopodium fruit in nano herbal form can reduce tissue damage such as diabetic wounds and renal and liver hypertension (Situmorang et al 2019a(Situmorang et al , 2019b(Situmorang et al , 2019c(Situmorang et al , 2021bManurung et al 2021).…”