Histological, Ultrastructural and Physiological Studies on the Effect of Different Kinds  Of Energy Drinks on the Liver Of Wistar Albino Rat

Khayyat, Latifa Ishaq; Sorour, Jehan; Essawy, Amina E.; Rawi, Maisaa Al

doi:10.24178/ijrs.2015.1.2.15

Cited by 28 publications

(38 citation statements)

References 12 publications

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“…It can be reasonably suggested that the lesions were brought about by tissue damage arising from ED-induced oxidative stress. These results are consistent with a previous report on evidence of hepatotoxicity and alterations in liver ultrastructure in rats treated with different types of EDs [22]. In another study, the lesions in liver and kidney tissues were attributed to potential reaction of taurine with some other active ED ingredient such as caffeine [23].…”

Section: Discussionsupporting

confidence: 93%

“…In another study, the lesions in liver and kidney tissues were attributed to potential reaction of taurine with some other active ED ingredient such as caffeine [23]. In addition, Khayyat and his colleagues found that rats treated with EDs had hepatic cytoplasmic vacuolations due to presence of lipid droplets which were attributed to deteriorative changes within hepatocytes [22].…”

Section: Discussionmentioning

confidence: 99%

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Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Mansy¹,

Alogaiel²,

Hanafi³

et al. 2018

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Mansy¹,

Alogaiel²,

Hanafi³

et al. 2018

Trop. J. Pharm Res

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“…Furthermore, the histology of one female rabbit in this experimental group that died within the first week of the study and male rabbits sacrificed on day 28 showed hepatic abnormalities such as congestion of central veins and balloon degeneration of hepatocytes. Similar hepatic and renal pathologies were reported in rats by many other researchers (Akande and Banjoko, 2011;Khayyat et al, 2012;Khayyat et al, 2014a), lending credence to the fact that injuries caused by RB and other energy drinks cannot solely be explained by increased fluid intake. In the group of rabbits (group 2) that received 11.5 ml of RB, a dose equivalent to half can or 125 ml of energy drink (which contains 46.3 mg taurine and 3.6 mg caffeine), there were no significant biochemical or haematological changes in the male rabbits and no mortality was recorded.…”

Section: Discussionsupporting

confidence: 60%

“…From the findings of this current study and some more recent ones testing different types of energy drink on rats (Khayyat et al, 2012;Chimezie, 2013;Khayyat et al, 2014aKhayyat et al, , 2014b and rabbits (Ebuehi et al, 2011), RB and other energy drinks may be associated with acute reversible hepatic, renal and possibly haematopoietic injury, which may not be totally explained by increased fluid intake or glucose loading in the drink. Furthermore, the histology of one female rabbit in this experimental group that died within the first week of the study and male rabbits sacrificed on day 28 showed hepatic abnormalities such as congestion of central veins and balloon degeneration of hepatocytes.…”

Section: Discussionmentioning

confidence: 92%

Toxicodynamic Effects of ‘Red Bull’ Energy Drink in A Randomised Controlled Study on Local Strains of Adult Rabbits

Taiwo¹,

Adesokan²

2018

JBLS

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Increasing reports of anecdotal cases of acute adverse effects associated with the consumption of energy drink have been expressed by international bodies. This has necessitated the need to assess toxicological effects of Red Bull (RB) energy drink in this study. Eighteen adult rabbits were randomly divided into 3 groups of 6 rabbits (3 males and 3 females). Rabbits in groups 1, 2 and 3 (control) received daily oral doses of 23.1 ml RB, 11.5 ml RB and water respectively for 21 days. Venous samples were collected on days 1 (baseline), 14, 21 and 28, and animals were sacrificed on days 21 and 28. Biochemical assessment of liver and renal functions, and muscle activity were carried out by spectrophotometry, in addition to haematological and histological studies. Mortality of 11.1% was recorded, involving 2 female rabbits in group 1. For male rabbits in this group, significant increase (p<0.05) in total protein (TP) concentration and in activity of ALT and ALP occurred on days 14 and 21, with significant decrease in platelet counts. For female rabbits in group 2, significant increases in TP concentration and ALT activity were observed with significant decrease in albumin concentration and AST activity. Apart from slight increase in ALP activity of female rabbits, there were no significant differences in mean values of all rabbit parameters measured in the control group. Histology of rabbits in group 1 showed congestion and balloon degeneration of hepatocytes. This result showed that administration of RB to rabbits at doses lower than the manufacturer's recommended equivalent daily human intake of 500 ml caused adverse effects. There is need for caution in consumption of this drink.

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“…These organs include testis (Dias et al, 2015), pancreas, fundus of stomach (Ayuob and ElBeshbeishy, 2016), and liver (Khayyat et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Expression of transcription factor NF-KAPPA B/P65 and cyclooxygenase-2 (COX-2) in testicular damage induced by Red Bull energy drink in rat

Ahmed

2016

Int. j. adv. appl. sci

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The risks of heavy consumption of energy drinks have become a significant health problem. Concerns have been raised about the adverse health effects of these products. This study was performed to investigate the possible histopathological and immunohistochemical changes in the testis induced by excessive and prolonged consumption of Red Bull, one of the most consumed energy drinks all over the world, in rats and the possible mechanism of such changes. Thirty adult male albino rats were randomly allocated into two groups, each of 15 animals. Rats of control group received distilled water (1.071ml/100 g/day) for three months. Rats of Red Bull group received an equivalent dose of Red Bull for three months. At the end of the experiment, all animals were sacrificed under anesthesia and the testes were excised and processed for histopathological and immunohistochemical studies. Consumption of Red Bull energy drink caused extensive atrophy and damage of numerous seminiferous tubules with marked loss of germinal epithelial cells and marked interstitial edema. Immunostaining results demonstrated marked increase of NF-kB/p65 and COX-2 in testis of rats following consumption of Red Bull energy drink. The results of this study suggest that excessive and prolonged consumption of Red Bull energy drink induces extensive histopathological lesions in the testis of rats through upregulation of NF-kB/p65 and COX-2.

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Histological, Ultrastructural and Physiological Studies on the Effect of Different Kinds Of Energy Drinks on the Liver Of Wistar Albino Rat

Cited by 28 publications

References 12 publications

Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Toxicodynamic Effects of ‘Red Bull’ Energy Drink in A Randomised Controlled Study on Local Strains of Adult Rabbits

Expression of transcription factor NF-KAPPA B/P65 and cyclooxygenase-2 (COX-2) in testicular damage induced by Red Bull energy drink in rat

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