Histomorphometric analysis of microcrack healing after the installation of mini-implants

Shin, Soobin; Park, Pan-Soo; Baek, Seung‐Hak; Yang, Il-Hyung

doi:10.5051/jpis.2015.45.2.62

Cited by 3 publications

(1 citation statement)

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“…This observation reinforces the involvement of fluid flow in the propagation of NF-κB activation throughout the cortical bone as well as the importance of the cortical bone as a manager of the bone remodeling. Moreover, communicating junctions facilitate also the passage and propagation of the ions Ca++ through osteocytes allowing intracellular communication [44], and thus, inducing stress responses [45]. When an implant is inserted, Ca++ passage is impaired and ion propagation through channels is reduced.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Trauma Intensity during Surgical Bone Procedures Using NF-κB Expression Levels as a Stress Sensor: An Experimental Study in a Wistar Rat Model

et al. 2018

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Aim and objectives: It is well known that the transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and functions as a pivotal mediator of inflammatory responses. In the present study, we evaluated the trauma generated (inflammatory reaction) after osteotomy bone surgical procedures and placement of implants in the femoral cortical bone of Wistar rats. Surgical stress was evaluated measuring the release and activation of the NF-κB factor. Materials and Methods: Rats were divided into four groups (n = 10) and submitted to different surgical treatments: Control Group (G1 group), only bone perforation was performed without irrigation; Implant Group (G2 group), a titanium implant was inserted after bone perforation without irrigation; Irrigated Group (G3 group) perforations were performed with intense irrigation; and Vitaminic Compound Group (G4 group) surgical perforation was performed without irrigation and a vitaminic compound containing the principal ions present in the natural bone structure was used to fill the bone defect. All animals were euthanized six hours after the surgical procedure and NF-κB levels were determined through immunohistochemical stain followed by direct counting of labeled and unlabeled osteocytes. Results: Among different treated groups, the overall mean of the NF-κB positive cell count in all positions were higher for G1 group (33.4 ± 2.45 cells). NF-κB values were lower in the G2 group (28.9 ± 2.70 cells), whereas in the G3 group (24.3 ± 2.72 cells) as well as in G4 group still lesser NF-κB positive cells were counted (26.5 ± 2.60 cells). Conclusions: The results here presented suggest that maneuvers performed during osteotomy procedures can significantly affect inflammation levels. The NF-κB activation during the surgical procedures can be minimized and/or controlled thought the adequate irrigation or application of adequate substances.

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Section: Discussionmentioning

confidence: 99%