Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps

Savelli, L.; Iaco, Pierandrea De; Santini, Donatella; Rosati, F.; Ghi, T.; Pignotti, Elettra; Bovicelli, Luciano

doi:10.1067/mob.2003.247

Cited by 244 publications

(218 citation statements)

References 20 publications

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“…These findings seem to be similar to those reported in previous studies in which malignancy rate was described to vary between 0.8 and 8 % [12,[19][20][21][22]. One study reported a high prevalence of hyperplasia without cytologic atypia (25.7 %) and a prevalence of hyperplasia with atypia (3.1 %), and it added that polyps represent a wide spectrum of alterations that range from normal endometrium to cancer [12].…”

Section: Resultssupporting

confidence: 77%

“…Once a polyp has been identified, operative hysteroscopy is often the treatment of choice in the resection of endometrial polyps and the evaluation of the endometrial cavity, allowing complete removal of the lesion and biopsy of the suspicious areas in the adjacent endometrium [12]. The objectives of this study were to determine the incidence of premalignant and malignant lesions in symptomatic as well as asymptomatic endometrial polyps in premenopausal women and to assess whether different clinical parameters, and polyp volume and number are associated with malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women

Elfayomy

Soliman

2014

J Obstet Gynecol India

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Objective This study aimed to evaluate the prevalence of premalignant and malignant lesions of symptomatic and asymptomatic endometrial polyps among premenopausal women and to verify whether different clinical parameters, and polyp volume and number are associated with a more precise estimate of malignancy. Methods One hundred and fifty women aged 29-52 years and with certain diagnosis of endometrial polyp were enrolled in a prospective observational study. The recruited patients underwent hysteroscopic polypectomy based on saline infusion sonohysterography and diagnostic hysteroscopy. Pathologic report was the main outcome. Results Among women with endometrial polyps, 62 % had asymptomatic polyps. The prevalence of premalignant and malignant polyps comprised 4.6 % of cases (3.3 % hyperplasia with atypia and 1.3 % carcinomatous polyps). The presence of abnormal uterine bleeding was not a predictor of premalignant and malignant changes in the polyp. On logistic regression analysis, the premalignant and malignant lesions were influenced by polycystic ovary syndrome (p \ 0.001; OR 4.61; CI 1.9-27), polyp volume [10 ml (p \ 0.001; OR 5.83; CI 4.31-9.17), and multiple polyps (p = 0. 01; OR 2.05; CI 1.09-3.76). Notably, the odds ratio of polyp volume [10 ml was 5.83. This additional risk confirms the importance of polyp volume in the detection of malignant transformation rather than associating bleeding in premenopausal women. Conclusion Polycystic ovary syndrome, polyp volume greater than 10 ml, and increased polyp number represent the markers of risk for premalignant and malignant 123 transformation of endometrial polyps in premenopausal women. Nonetheless, the majority of polyps are asymptomatic, and the risk of malignancy is very low. Therefore, for women with polyp volume B10 ml and no risk factors, a more expectant approach may be warranted in order to reduce surgical risks and costs.

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Section: Resultssupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women

Elfayomy

Soliman

2014

J Obstet Gynecol India

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“…(Kurman et al). En el 3,1% evidenciaron hiperplasia con atipia y sólo el 0,8% resultó ser canceroso, por lo tanto, sólo un 3,9% constituirían riesgo (Savelli et al, 2003).…”

Section: Discussionunclassified

Estudio inmunocitoquímico de Receptores de Estrógeno Fracción Alfa y de Progesterona en Pólipos Endometriales

et al. 2005

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“…There is a risk factor for a concomitant endometrial pathology (hyperplasia, sarcoma, and carcinoma) in postmenopausal endometrial polyps. Savelli et al found that malignancy potential of EP is 0.8% (Savelli et al, 2003). Anastasiadis et al (2000) in studying of 126 endometrial polyp cases s, found that 94 were benign, 30 were with premalignant changes (complex and atypical hyperplasias) and 2 had undergone malignant degeneration (Anastasiadis et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis and natural history of endometrial polyps are not very clear. It has three types: benign (atrophic, functional), hyperplastic and cancerous (Savelli et al, 2003). The prevalence of EP is between 6% and 32% (Dreisler et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Which Endometrial Pathologies Need Intraoperative Frozen Sections?

Balık

Kağıtçı²,

Üstüner³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps

Cited by 244 publications

References 20 publications

Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women

Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women

Estudio inmunocitoquímico de Receptores de Estrógeno Fracción Alfa y de Progesterona en Pólipos Endometriales

Which Endometrial Pathologies Need Intraoperative Frozen Sections?

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