Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

Nieuwenhuis, Eline J. C.; Waal, I. van der; Leemans, C. René; Kümmer, Alain; Pijpers, Rik; Castelijns, Jonas A.; Brakenhoff, Ruud H.; Snow, Gordon B.

doi:10.1002/hed.20126

Cited by 43 publications

(27 citation statements)

References 29 publications

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“…289 The sensitivity of SLN biopsy for squamous cell carcinoma of the oral cavity and oropharynx is reported to be between 89% and 100% and the false-negative rate 1% to 4%. [287][288][289] Preliminary studies have shown that SLN biopsy is a promising tool for use in patients with early oral and oropharyngeal squamous cell carcinoma. 289,290 These investigations also have shown, however, that multiple, bilateral, or skip SLN may occur.…”

Section: Sentinel Lymph Nodementioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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Section: Sentinel Lymph Nodementioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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“…The use of specific markers in diagnosing occult metastasis has been utilized in a number of malignancies, such as breast carcinoma, melanoma, gynecologic malignancies, oral and head and neck malignancies, colorectal cancer, and Merkel cell carcinoma. [12][13][14][15][16][17] Although originally developed in other organs, sentinel lymph node biopsy has gained widespread use in breast cancer. 18 On the basis of the results of large randomized trials confirming its efficacy and reduced morbidity, sentinel lymph node biopsy has become a standard of care for axillary evaluation in breast cancer patients with early stage disease in many institutions.…”

Section: Discussionmentioning

confidence: 99%

The role of OCT4 immunohistochemistry in evaluation of retroperitoneal lymph node dissections: a pilot study

et al. 2013

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We investigated the role of OCT4 immunohistochemical staining in detecting germ cell tumor lymph node metastases. Retroperitoneal lymph node dissection is important for staging and treatment of testicular germ cell tumors, and OCT4 is sensitive and specific for pluripotent testicular germ cell tumors; however, micrometastases, particularly from seminoma, can be difficult to detect. We examined 262 lymph nodes in 45 retroperitoneal lymph node dissection specimens from germ cell tumor patients. Specimens were categorized as postchemotherapy and untreated retroperitoneal lymph node dissection with or without clinical suspicion, based on lymphadenopathy or elevated serum germ cell tumor markers. Sections were stained with anti-OCT4 antibody. Twenty-one additional positive lymph nodes in 12 cases were detected to harbor scattered seminoma cells, singly and in small clusters, from 256 previously considered benign in: untreated retroperitoneal lymph node dissection with clinical suspicion (13% increase), postchemotherapy retroperitoneal lymph node dissection (7%), and untreated retroperitoneal lymph node dissection without suspicion (4%). However, no patient with an entirely negative dissection specimen was reclassified as positive. OCT4 immunohistochemistry detected scattered seminoma cells and small clusters of seminoma cells in lymph nodes previously considered to be benign for an overall increase of 8%, greatest in the setting of untreated retroperitoneal lymph node dissection with clinical suspicion. However, immunohistochemistry did not convert any entirely negative specimen to positive. Future studies will be useful to determine whether the small volume of disease detected by immunohistochemistry has the same impact as routinely detected lymph node metastases.

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“…Le curage est ré alisé uniquement si le GS montre un envahissement tumoral. En effet, de nombreuses é tudes ont validé la fiabilité de cette technique, qui n'engendre pas plus d'é chec ganglionnaire que l'é videment de principe, aussi bien en termes de contrô le local que de survie [5,[15][16][17][18]25,27,29]. Les patients chez qui aucun traitement chirurgical n'a é té retenu, pourraient aussi bé né ficier de la recherche du GS dans une optique de dé flation thé rapeutique.…”

Section: Gs : Indicationsunclassified

“…Le concept de chirurgie « minimale invasive » qui a é té dé veloppé cette derniè re dé cennie, toutes spé cialité s confondues, a trouvé une place dans la chirurgie cervicale ganglionnaire grâ ce à l'utilisation, sous certaines conditions, de la recherche du ganglion sentinelle (GS), dé fini comme le premier relais lymphatique effé rent de la tumeur primitive. En l'absence d'invasion de ce ganglion, un curage de principe peut ê tre é vité , car le statut histologique du GS est repré sentatif de celui des autres ganglions du cou [18]. Ce procé dé qui repose sur la lymphoscintigraphie pré opé ratoire est dé jà validé et utilisé en routine dans d'autres domaines que sont, par exemple, la chirurgie du mé lanome malin cutané et les cancers du sein.…”

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Le ganglion sentinelle dans les carcinomes épidermoïdes de la tête et du cou

et al. 2009

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Node involvement is a major prognostic factor in head and neck cancers. Among N0 staged patients, because 15 to 30% have occult node metastasis, systematic radical modified neck dissection is frequently performed, although it is subsequently demonstrated to have been unnecessary in two thirds of the cases. With respect to minimal invasive surgery, an understanding of the head and neck lymphatic anatomy and experience of sentinel node biopsy in cutaneous melanoma and breast cancer endorse such an approach, particularly for T1-T2 N0 head and neck squamous cell carcinoma of the oral cavity and oropharynx. Progress in histological diagnosis is expected by way of targeted cervical lymphatic molecular analysis.Keywords: Head and neck -Squamous cell carcinoma -Lymphatic metastasis -Neck dissectionSentinel node Ré sumé : L'atteinte ganglionnaire est un facteur pronostique majeur des cancers ORL. Parmi les patients classé s N0, 15 à 30 % sont porteurs de mé tastases ganglionnaires infracliniques, ce qui impose un curage cervical de principe systé -matique pourtant inutile dans les deux tiers des cas. Dans l'optique d'une dé flation thé rapeutique, la connaissance de l'anatomie lymphatique du cou et l'expé rience de la recherche du premier ganglion atteint dans la chirurgie du sein et du mé lanome malin cutané ont permis de valider la recherche du ganglion sentinelle (GS) dans les carcinomes é pidermoïdes ORL de stade limité T1-T2 N0, pré fé rentiellement de la cavité buccale et de l'oropharynx. Le curage est ré alisé uniquement en cas d'atteinte du GS. L'analyse molé culaire ciblé e des ganglions pré levé s permettra des progrè s dans le diagnostic histologique.

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Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

Cited by 43 publications

References 29 publications

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

The role of OCT4 immunohistochemistry in evaluation of retroperitoneal lymph node dissections: a pilot study

Le ganglion sentinelle dans les carcinomes épidermoïdes de la tête et du cou

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