Histopathological changes in gallbladder mucosa associated with cholelithiasis

Baidya, Reena; Sigdel, Brihaspati; Baidya, NL

doi:10.3126/jpn.v2i3.6027

Cited by 14 publications

(21 citation statements)

References 5 publications

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“…Cholesterolosis was found in 13% to 14% cholelithiasis specimens in two other studies. 11,18 There was no case of carcinoma in situ in the present study but one case of carcinoma was observed (0.53%). A similar percentage of gall bladder carcinoma was noted in asymptomatic cases in another study (0.57%).…”

Section: Discussioncontrasting

confidence: 53%

“…This is comparable to age and gall stone findings observed in few other studies. [8][9]11 41-50 years of life (5 th decade) is reported to witness peak incidence. 10 In our study we did not get any case that was younger than 20 years of age during the study period.…”

Section: Discussionmentioning

confidence: 99%

“…Few other researchers noted dysplasia in 1.3% and 2.2% of cases in their studies. 11,17 However, one study reported dysplasia at 8.5%. 9 Discrepancy may be due to number of specimens in each study, and number of sections examined and also the severity of gall bladder cases presenting to different clinical settings.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

2020

IJPO

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Introduction: Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide. This research was carried out to study the varied histopathological changes in the gallbladder mucosa as a result of cholelithiasis. Materials and Methods: The present research comprised 190 gallbladder specimens obtained from cholecystectomy procedures conducted at tertiary teaching hospital in Bangalore. The gross examination was done after fixing the specimens with 10% formalin. Haematoxylin and eosin was used to stain gallbladder sections from fundus, body and neck. Results: On gross examination, congestion was noticed on surface of gall bladder in 67 cases (35.26%), wall was thickened in more than half of cases 104 (54.74%). Nearly a quarter of specimens showed pathological changes in mucosa of gallbladder (23.15%). Histopathological examination observed evident epithelial hyperplasia in 80 cases (42.1%), antral metaplasia in 20 (10.5%), intestinal metaplasia in 12 (6.3%), dysplasia with carcinoma in one case (0.53%). Conclusion: Gallstones produce a wide range of histopathological changes in mucosa and calls for dedicated attention of pathologist routinely.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

2020

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“…5 In Nepal, histopathological examination of cholecystectomy specimens has become a routine practice. [6][7][8][9] Gallstone disease, porcelain gallbladder, and sclerosing cholangitis are the best known risk factors for gallbladder cancer apart from some nonmodifiable factors such as increasing age, ethnicity, female gender and family history or genetics. 9,10 Cholecystectomies performed with preoperative diagnosis of gallstone disease rarely results in a diagnosis of unexpected gallbladder cancer.…”

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confidence: 99%

Importance of Routine Histopathological Examination of Gallbladder Specimen in Detecting Incidental Malignancies

Tiwari¹,

Rai²,

Jain³

2016

J Lumbini Med Coll

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Introduction: Gallbladder carcinoma is the most common cancer of biliary tree and the 5th most common gastrointestinal malignancy. An early diagnosis is essential as this malignancy progresses silently with a late diagnosis and poor prognosis. Epidemiological studies have identified striking geographic and ethnic variation with high occurrence in Southeast Asia, yet low elsewhere in the world. Gallbladder carcinoma, in 15-30% of patients, show no preoperative or intraoperative evidence and are detected only on histopathological examination. They are called as incidental gallbladder cancer (IGBC). The objective of this study was to find out the occurrence of IGBC in cholecystectomy specimens received in our histopathology laboratory and to analyze their clinico-pathological features. Methods: This was a prospective study carried out in the Department of Histopathology, Lumbini Medical College Teaching Hospital during a period of two years from May 2014 to April 2016. The study included 800 cases of cholecystectomized Gall bladder specimens. Result: Ninety seven percent of the specimens (n=776) revealed benign pathology. Malignancy was detected incidentally in 8 cases (1.25%). The mean age of patients with incidental Gall bladder carcinoma was 69 years (SD=4.1) and F:M ratio was 9:1. Out of 10 incidental malignancies, cholelithiesis was found in 8 (80%) cases. Fundus was the most common location (n=5, 50%) and focal fragile necrotic area was most common (n=3, 30%) gross morphology. On pathological staging, all the incidentally detected malignancies (n=10) were found to be in surgically resectable stages. Conclusion: IGBC was found in 1.25% of the gallbladder specimen. Detailed gross and histopathological examination of gallbladder specimen is mandatory for every cholecystectomy specimen, even for benign diseases, to detect incidental carcinoma at potentially curable stage.

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“…Female Male et al, followed by congestion of the serosa in 30 cases (18.63%). [13][14][15] 106 cases presented with calculi (65.84%) with 55 cases (34.16%) being acalculus. Majority of the cases (31.06%) presented as multiple gall bladder calculi followed by single stones in 22.36% of cases.…”

Section: 78% (56)mentioning

confidence: 99%

Histopathological spectrum of gall bladder lesions

Kulkarni¹,

Jadhav²,

Ramteke³

2020

Int J Res Med Sci

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Background: Gall bladder diseases are a very common health problem that affects millions of people throughout the world. Cholelithiasis is commonly associated with carcinoma gallbladder. Cholecystectomy is the most commonly performed surgical procedure done for gall bladder disease.Methods: A total of 161 cases of gall bladder lesions were evaluated from January 2017 to December 2018 which were sent to department of pathology. Specimens were fixed in 10% formalin. Appropriate areas were selected from the specimen and grossed, processed, sectioned, stained using haematoxylin and eosin and were observed under microscope.Results: Out of 161 cases, 105 were female (65.22%) and 56 cases were male (34.78%).Histopathologically, the most common diagnosis was Chronic calculus cholecystitis (57.76%) followed by chronic acalculus cholecystitis (22.36%). Remaining cases were of Acute on chronic cholecystitis (6.21%), Acute on chronic cholecystitis with cholelithiasis (4.96%), Acute on chronic cholecystitis with perforation peritonitis (1.24%), Acute suppurative cholecystitis with perforation peritonitis (0.62%), Biliary Atresia (1.24%), Chronic cholecystitis with choledochal cyst (1.24%), Follicular cholecystitis (1.24%), Adenocarcinoma (0.62%), Adenosquamous carcinoma (0.62%) and one case was inconclusive (0.62%).Conclusions: The incidence of chronic calculus cholecystitis was found to be 57.76% with female preponderance and mostly in third decade. Malignancy of gall bladder is a rare condition. Routine histopathological examination of all cholecystectomy specimens is strongly recommended for the detection of various variants of chronic cholecystitis and also of incidental carcinoma of gall bladder which helps in their treatment and prognosis.

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Histopathological changes in gallbladder mucosa associated with cholelithiasis

Cited by 14 publications

References 5 publications

Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

Importance of Routine Histopathological Examination of Gallbladder Specimen in Detecting Incidental Malignancies

Histopathological spectrum of gall bladder lesions

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