Hodgkin's Lymphoma in Elderly Patients: A Comprehensive Retrospective Analysis From the German Hodgkin's Study Group

Abstract

Elderly patients have a poorer risk profile compared with younger HL patients and experience more severe treatment-associated toxicity. Higher mortality during treatment as well as lower dose-intensity are the major factors explaining the poorer overall outcome of elderly HL patients.

Hodgkin’s Lymphoma - evaluation of patients submitted to Autologous transplantation of hematopoietic cells in the Hematology Service of the Hospital Walter Cantídio – Fortaleza, Brazil.

“…2,3,6 Currently, it is worth mentioning the new forms of treatment, including targeted therapy and the possibility of bone marrow trans- …”

Treatment of Early Stage Hodgkin Lymphoma

“…In this study, the recurrence of HL was found to have a significant negative impact on survival. In a more recent report by Engert A et al (Engert, Ballova, Haverkamp, et al, 2005), a comprehensive retrospective analysis from the GHSG data base was performed and yielded poorer outcomes for elderly patients. From 4251 patients, 372 (8.8%) were 60 years or older.…”

Classical Hodgkin's lymphoma in adults: guidelines of the Italian Society of Hematology, the Italian Society of Experimental Hematology, and the Italian Group for Bone Marrow Transplantation on initial work-up, management, and follow-up

“…54,55 Moreover, cardiovascular, respiratory and/or metabolic co-morbidities are important determinants of the less favorable prognosis of Hodgkin's lymphoma in the elderly. 56,57 The EP defined as elderly patients over 70 years and addressed the question of whether a conventional strategy or a reduced-intensity approach is more appropriate for this category of patients.…”