Honey ameliorates influence of hemorrhage and food restriction on renal and hepatic functions, and hematological and biochemical variables

Abstract

The objectives were to assess the effects of various diets, including total food restriction with 50% honey feeding, total food restriction with 50% dextrose feeding or adlibitum (control group) commercial regular diet, on the hematology and biochemical variables, and to assess the effects of the various diets on the influence of acute blood loss on the same parameters. Thirty Sprague-Dawley albino rats were divided into three groups, 10 rats each: group A, fed a commercial regular diet; group B, total food restriction with 50% dextrose feeding; and group C, total food restriction with 50% honey feeding. After 8 days of feeding, rats were subjected to acute blood loss (6 ml/kg) and blood investigations were performed. After acute blood loss, the same feedings were continued for a further 8 days and the blood tests were repeated at day 8 post-bleeding. Total food restriction with 50% dextrose feeding compared with commercial regular diet reduces hematological and biochemical variables. Total food restriction with 50% honey feeding compared with total food restriction with 50% dextrose feeding causes a greater reduction in fasting blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and triacylglycerol. Acute blood loss causes elevation of white blood cells, lymphocyte percentage, fasting blood sugar, blood urea nitrogen, alkaline phosphatase and triacylglycerol, and a reduction in serum albumen, protein, cholesterol, AST, serum creatinine and hemoglobin; the results are significant (P<0.05) concerning fasting blood glucose, AST, alkaline phosphatase, serum albumin and protein. A significant reduction in fasting blood glucose, white blood cells, BUN, AST, ALT, alkaline phosphatase and triacylglycerol, and a significant elevation of hemoglobin and serum albumin are obtained after acute blood loss in rats on total food restriction with 50% honey feeding as compared with the other two groups. Total food restriction with 50% honey feeding increases serum albumin, serum protein, fasting blood glucose, and causes lower reduction in hemoglobin as compared with the other groups. Conclusively, honey feeding during total food restriction significantly modifies and ameliorates biochemical and hematological changes observed after acute blood loss. This will pave the way to use honey as part of bleeding management and during a food restriction regimen.

Honey prevents hepatic damage induced by obstruction of the common bile duct

“…Furthermore, the scolicidal efficacy of propolis, which is a resinous material obtained by honey bees from plants or flowers, has been shown in cystic hydatid disease [19] . Recently, it has been found that honey leads to increased levels of NO in biological fluids and to reduced liver enzymes, such as AST and ALT, in blood [20] .…”

Tualang honey ameliorates restraint stress-induced impaired pregnancy outcomes in rats

“…However it is postulated that vitamins such as vitamins A, C and E, as well as flavonoids and phenolic acids [6][7][8][9]. Studies have demonstrated some beneficial effects of honey such as gastrointestinal [10,11] and reproductive protections [12], as well as hypoglycaemic [13], antihypertensive [7], antibacterial [14], antifungal [15], anti-inflammatory [16] and antioxidant [12,17] effects. Honey has been used as a traditional nutrient by local Malaysian population to enhance fertility and vitality.…”

Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

“…It was concluded that honey feeding during total food restriction has protective effects on both liver and kidney after acute blood loss [19]. In another experiment, we found that oral honey feeding significantly ameliorates biochemical and hematological changes obtained after CCl4 injection; showing hepato-renal protection [20].…”

“…We have found that honey has beneficial effects on renal function in normal volunteers [18]. In addition, our studies demonstrated that honey can protect liver and kidney during acute blood loss and after CCl4 intoxication [19][20][21]. Honey has been mentioned in Holey books as a healer of diseases.…”