Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2). It is a highly metastasized, heterogeneous disease that accounts for 10–15% of total breast cancer cases with a poor prognosis and high relapse rate within five years after treatment compared to non-TNBC cases. The diagnostic and subtyping of TNBC tumors are essential to determine the treatment alternatives and establish personalized, targeted medications for every TNBC individual. Currently, TNBC is diagnosed via a two-step procedure of imaging and immunohistochemistry (IHC), which are operator-dependent and potentially time-consuming. Therefore, there is a crucial need for the development of rapid and advanced technologies to enhance the diagnostic efficiency of TNBC. This review discusses the overview of breast cancer with emphasis on TNBC subtypes and the current diagnostic approaches of TNBC along with its challenges. Most importantly, we have presented several promising strategies that can be utilized as future TNBC diagnostic modalities and simultaneously enhance the efficacy of TNBC diagnostic.
The present study reports on the infection rates of hydatid cysts in both sexes and different age groups of sheep, camels and cattle from government abattoirs in different parts of Libya. An infection rate of 10.06% was recovered among 32,971 all ruminants (sheep, camels and cattle). Out 25314 of sheep, 2659 (10.52%) were infected. Out 7496 of camels, 940 (12.54%) were infected. Out 161 of cattle, 17 (10.56%) were infected. As regards to the infected organs, liver was seen to be the most commonly infected organ in sheep and cattle (46.03%; 52.94%, respectively), but in camels, it was the lung (55.21%). The fertility rates of hydatid cysts were 80% in sheep, 84% in camels and 0% in cattle. In sheep, the fertility rate of liver hydatid cysts was higher than that in other organs (53.85%), but in camels, the fertility rate in the lung was higher than that of other infected organs (66.7%). Thus, the incidence of echinococcosis in slaughtered livestock is noticeably high and denotes some hazards in control measures in Libyan abattoirs.
During the first phase of the Movement Control Order, many medical lecturers had difficulty adapting to the online teaching and learning methods that were made compulsory by the institutional directives. Some of these lecturers are clinicians who need to juggle between clinical work and teaching, and consider a two-week adaptation during this period to be not enough. Furthermore, converting traditional face-to-face learning to online formats for undergraduate and postgraduate clinical programmes would reduce the learning outcomes, especially those related to clinical applications and the acquisition of new skills. This editorial discusses the impact that movement restrictions have had on medical teaching and learning, the alternatives and challenges and the way forward.
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