Honeycomb-patterned films of polystyrene/poly(ethylene glycol): preparation, surface aggregation and protein adsorption

Wan, Ling‐Shu; Ke, Bei-Bei; Li, XiaoKai; Meng, Xiang‐Lin; Zhang, Luyao; Xu, Zhi‐Kang

doi:10.1007/s11426-009-0007-1

Cited by 25 publications

(26 citation statements)

References 35 publications

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“…A recently studied strategy to fabricate protein micro‐arrays is based on the selective protein adsorption to polymer patterns,8, 9, 11 for instance, the surface domains of hydrophobic and hydrophilic polymers formed by self‐assembly during spin‐coating [Fig. 7(e)] 10, 22, 30, 54–60. The patterned proteins, which preserve specific binding with their ligand, can be used to construct tiny counterparts of conventional immunoassays61 or to induce inhomogeneous cell seeding 62…”

Section: Methodsmentioning

confidence: 99%

Polymer blends spin‐cast into films with complementary elements for electronics and biotechnology

Budkowski

Zemła

Moons

et al. 2012

J of Applied Polymer Sci

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Versatility of solution-processing strategy based on the simultaneous rather than additive deposition of different functional molecules is discussed. It is shown that spin-cast polymer blends result in films with domains that could form elements with complementary functions of (i) solar cells, (ii) electronic circuitries, and (iii) test plates for protein micro-arrays: Alternating layers, rich in electrondonating polyfluorene and electron-accepting fullerene derivative, result in optimized solar power conversion. Surface patterns, made by soft lithography, align conductive paths of conjugated poly(3-alkylthiophene) in dielectric polystyrene. Proteins, preserving their biologically activity, are adsorbed to hydrophobic domains of polystyrene in hydrophilic matrix of poly(ethylene oxide). The authors report the research progress on structure formation in three polymer blend families, resulting in films with complementary elements for electronics and biotechnology. Blend film structures are determined with secondary ion mass spectrometry, atomic force microscopy, and fluorescence microscopy. In addition, the authors present recent results on (i) structure formation in fullerene derivative/poly(3-alkylthiophene) blends intended for solar cells, (ii) 3-dimensional SIMS imaging of conductive paths of poly(3-alkylthiophene) in dielectric polystyrene, (iii) test plates for multiprotein micro-arrays fabricated with blend films of hydrophobic polystyrene and thermoresponsive poly(N-isopropylacrylamide). V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 125: [4275][4276][4277][4278][4279][4280][4281][4282][4283][4284] 2012

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Section: Methodsmentioning

confidence: 99%

Polymer blends spin‐cast into films with complementary elements for electronics and biotechnology

Budkowski

Zemła

Moons

et al. 2012

J of Applied Polymer Sci

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“…Due to the hydrophobic nature of this polymer, it is difficult for polar reagents to enter and swell the matrix [38]. Polystyrene can be modified by grafting PEG to the hydrophobic core to produce a polymer that can swell in both nonpolar and polar solvents [18][19][20][21][22]. Among these PEG-grafted polystyrene supports, TentaGel (Figure 2(a)) has been used extensively in solid phase synthesis because of the mechanical stability of the beads and relatively uniform swelling property in a variety of solvents from low to high polarity.…”

Section: Pegylation Of Crosslinked Ps Resins and Their Derivativesmentioning

confidence: 99%

“…In order to overcome the shortcomings of the Merrifield resins, polystyrene is modified by grafting poly(ethylene glycol) (PEG, Figure 1(b)) to the hydrophobic core to produce a polymer that swells in both nonpolar and polar solvents [18][19][20][21][22]. The modified PS resins including TentaGel ( Figure 2(a)) and ArgoGel (Figure 2(b)) have been developed and commercialized.…”

Section: Introductionmentioning

confidence: 99%

PEG-related polymer resins as synthetic supports

Wang

Yang

Zhu³

et al. 2010

Sci. China Chem.

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Combinatorial chemistry has become a significant part of the discovery and optimization process for novel drugs, affinity ligands, and catalysts. The polymeric supports play a key role in combinatory chemistry. Therefore, various kinds of functional polymer resins have been exploited as supports, reagents, and catalysts in organic synthesis. In comparison to the conventional Merrifield resins, the poly(ethylene glycol) (PEG)-related polymer resins have advantages including good compatibilities with polar solvents, good solvent absorbency and swelling properties. This review focuses primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis. combinatorial chemistry, polymer resins, poly(ethylene glycol), organic synthesis

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“…The size and regularity of the pores mostly depends on the type and concentration of the additive. In the third method, the blend of PS homopolymer and a polar homopolymer or an amphiphilic polymer are utilized for pattern formation . Finally, in the fourth method, the architecture and structure of the PS are changed.…”

Section: Introductionmentioning

confidence: 99%

Stabilization of self‐assembled microdroplets using short chain alcohols

Farajollahi

Marti

Amirkhani

2015

J Polym Sci B Polym Phys

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The condensation of water vapor on a volatile polymeric solution leads to a porous surface after evaporation of both solvent and water. However, the stabilization of the water microdroplet is of great importance, which can be achieved using specific polymer or adding a third substance to the polymer solution. Short chain alcohols (methanol, ethanol, and n‐propanol) are utilized to fabricate a self‐assembled porous honeycomb film of linear, low molecular weight polystyrene using the breath figure technique. A combination of breath figure processing and the effect of alcohol on a water droplet can stabilize the pattern and make pores on the surface of the polymer film. The quality of the porous honeycomb film is strongly dependent on the type of alcohols and the concentration of polymer. In a specific range of polymer and alcohol concentration, pores cover all the surface of the polymer film. This method offers the possibility of producing a honeycomb structure with no trace of additive residual after the fabrication process and avoiding polymer modification. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 709–718

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Honeycomb-patterned films of polystyrene/poly(ethylene glycol): preparation, surface aggregation and protein adsorption

Cited by 25 publications

References 35 publications

Polymer blends spin‐cast into films with complementary elements for electronics and biotechnology

Polymer blends spin‐cast into films with complementary elements for electronics and biotechnology

PEG-related polymer resins as synthetic supports

Stabilization of self‐assembled microdroplets using short chain alcohols

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