Hormonal changes and spermatogenesis of male rat puppies born by mothers consuming soybean extract

Nurdiana, Nurdiana; Mayangsari, Elly; Lestari, Bayu; Setiawan, Bambang

doi:10.1016/j.apjr.2016.10.009

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…These findings are similar to Nuridiana and Modaresi who stated in their research separately that there is a marked decrease in folliclestimulating hormone levels in the group treated with Soy protein. 23,22 25 The limitations of the study were that the sample size was small N=30(10 Male Sprague Dawley rats in Group 1, 10 Male Sprague Dawley rats in Group 2 and 10 Male Sprague Dawley in Group 3). Due to productive cost and the unavailability of rats' the sample size was kept limited.Study duration was short.…”

Section: Discussionmentioning

confidence: 99%

Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study

Safdar,

Mughal,

Ain

et al. 2023

JRMC

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Objective: The purpose of this study was to assess the protective effects of zinc against injury to sperm parameters and male reproductive hormones brought on by toxic protein supplement constituents. Methods: 30 male Sprague Dawley rats were used in the study, of which 10 were in Group 1 (given standard laboratory food), 10 were in Group 2, fed standard laboratory food nutritional supplement powder and 10 were in Group 3, fed standard laboratory food, nutritional supplement powder and zinc. Semen Analysis of Male Sprague Dawley rats of all 3 groups was evaluated after 8 weeks. Sperm parameters and serum levels of Male Reproductive Hormones were measured at the beginning and the end of the study. Results: There was a significant decrease (P<0.05) in Mean ± SEM of sperm count millions /ml, sperm motility (%), and normal sperm morphology (%) in Group 2 rats when compared with Group 1. Zinc supplement in Group 3 caused a significant increase (P<0.05) in Mean ± SEM of sperm parameters including sperm count millions /ml, sperm motility (%) and normal sperm morphology (%) as compared to Group 2 rats. Mean ± SEM of serum level of testosterone Hormone, Follicle Stimulating Hormone(FSH), and Luteinizing Hormone(LH) of Group 2 rats showed a significant (P<0.05) decrease when compared with Group 1 rats. However, the use of Zinc in Group 3 rats significantly (P<0.05) increased serum Testosterone, FSH, and LH levels when compared to Group 2. No significant difference was noted between serum levels of Testosterone, in Group 1 and Group 3. Serum levels of FSH and LH in Group 3 rats (484.81+ 78.17 ng/ml) were significantly increased (P<0.05) as compared to Group 1 rats. Conclusion: Regular addition of antioxidant Zinc with protein supplements has the potential to restore normal functions of the male reproductive system. Keywords: Protein supplements, Soy Protein, Silicon dioxide, Zinc, Sperm parameters, Testosterone, Follicle stimulating hormone, Luteinizing hormone.

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Section: Discussionmentioning

confidence: 99%

Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study

Safdar,

Mughal,

Ain

et al. 2023

JRMC

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“…It was found that soybean extract decreased the levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) on male Wistar rat pups whose mother was given soy extract during pregnancy and breastfed the cubs until 2 months of age [6]. There was also a decrease in testosterone levels and abnormalities of spermatogenesis.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Soy Milk on Mounting Latency, Mounting Frequency, and Reproductive Development in Male Wistar Rats (Rattus Norvegicus)

Nurdiana

Chania

Nurvitasari

et al. 2021

Open Access Maced J Med Sci

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AIM: This research aims to examine the effects of soy milk on mounting latency (ML), mounting frequency (MF), estrogen levels, androgen-binding protein (ABP) expression, and spermatogenesis in male rats (Rattus norvegicus). METHODS: Twenty-four male wistar rats (Rattus norvegicus) aged 4 weeks were divided into four groups. Control group (given a normal diet), P1; P2; P3 (given the normal diet and soy milk powder at doses of 7.1; 14.2; 21.3 g/KgBW/day, respectively) for 6 weeks. Observation of ML and MF were performed at 9 weeks 5 days of age, and rat surgery was performed at 10 weeks of age. Analysis of estrogen hormone levels was conducted by enzyme-linked immunosorbent assay (ELISA), ABP staining was using immunohistochemistry method, testicular spermatogenesis was observed using histopathological methods, and observation of spermatozoa was performed under the microscope. RESULTS: The results showed no significant reduction of ML and MF, estrogen levels, and ABP expression (p ≤ 0.256; 0.865; 0.959, respectively) in male rat, but there was a significant decrease in the number, morphology, motility of spermatozoa, and testicular histophatology, (p ≤ 0.000, 0.003, 0.008, 0.000, respectively). CONCLUSION: The administrassion of soy milk in various doses (7.1;14.2;21.3 g/KgBW/day) in male Wistar rats (Rattus norvegicus) had showed significantly difference on histopathological evaluation using Johnson’s scoring system, sperm quantity and quality, while on mounting latency and frequency, estrogen levels, and ABP expressions did not show significantly difference between groups. That describe of isoflavone in soy milk can affect several aspects related to male endocrine and reproductive development.

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Hydro-Ethanol Extracts of Xylopia aethiopica Enhanced Serum Testosterone Levels in Male Adult Wistar Rats

Emokpae,

Emokpae

2024

FSR

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Objectives To investigate the effects of hydro-ethanolic extracts of leaves and fruit with or without seeds on male sex hormones. Material and Methods Hydro-ethanolic extracts of the leaves, fruits with seeds, and fruits without seeds were processed using the Soxhlet extraction technique. Wistar rats were administered 125, 250, and 500 mg/kg of the extracts by oral gavage for 30, 60, and 90 days while the control group received feeds and water ad libitum. After the treatment periods, rats were sacrificed by cervical dislocation, and blood was collected by cardiac puncture. Serum follicle-stimulating hormones (FSHs), luteinising hormone (LH), progesterone, prolactin, and testosterone levels were determined using an enzyme-linked immunosorbent assay technique. Data were compared using analysis of variance (ANOVA), and a p-value of 0.05 was considered significant. Results Serum testosterone, FSH, and LH levels in rats treated with 125, 250, and 500 mg/kg were significantly increased (p < 0.05) in a dose-dependent manner compared with controls. Conclusion The consumption of this commonly used food spice appears to have beneficial effects on the male sex hormones.

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Hormonal changes and spermatogenesis of male rat puppies born by mothers consuming soybean extract

Cited by 3 publications

References 18 publications

Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study

Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study

The Effect of Soy Milk on Mounting Latency, Mounting Frequency, and Reproductive Development in Male Wistar Rats (Rattus Norvegicus)

Hydro-Ethanol Extracts of Xylopia aethiopica Enhanced Serum Testosterone Levels in Male Adult Wistar Rats

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