Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology–oncology patients

Gooskens, Jairo; Marijt, W.A.F.; Essen, E. H. R. van; Rimmelzwaan, Guus F.; Kroes, Aloys C.M.

doi:10.1038/bmt.2015.214

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…We did not detect the D222G substitution in HA known to be associated to illness severity (Casalegno et al, 2014;Goka et al, 2014). Severe respiratory distress was concomitant with partial immune reconstitution leading to inflammation; viral clearance was observed only when lymphocytes increased (Gooskens et al, 2016).…”

Section: Discussioncontrasting

confidence: 55%

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

et al. 2018

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Section: Discussioncontrasting

confidence: 55%

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

et al. 2018

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“…Epidemiological studies have shown an incidence of upper and lower respiratory infections in children undergoing HSCT of around 20-30% (Bredius et al, 2004;Verdeguer et al, 2011;Srinivasan et al, 2011aSrinivasan et al, , 2013. Progression to a lower respiratory tract infection can be influenced by patients' age and lack of immune reconstitution after transplant (El Saleeby et al, 2008;Srinivasan et al, 2011b;Gooskens et al, 2016). Overall, there are few specific recommended anti-viral treatments, and for a large proportion of respiratory viruses there is no evidence on efficacy for prophylaxis or therapy (Hirsch et al, 2013;Dignan et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality

et al. 2019

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Summary Viral respiratory infections (VRIs) contribute to the morbidity and transplant‐related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and strategies to prevent and treat VRIs are warranted. We monitored VRIs before and after transplant in children undergoing allogeneic HSCT with nasopharyngeal aspirates (NPA) and assessed the impact on clinical outcome. Between 2007 and 2017, 585 children underwent 620 allogeneic HSCT procedures. Out of 75 patients with a positive NPA screen (12%), transplant was delayed in 25 cases (33%), while 53 children started conditioning with a VRI. Patients undergoing HSCT with a positive NPA screen had a significantly lower overall survival (54% vs. 79%) and increased TRM (26% vs. 7%) compared to patients with a negative NPA. Patients with a positive NPA who delayed transplant and cleared the virus before conditioning had improved overall survival (90%) and lower TRM (5%). Pre‐HSCT positive NPA was the only significant risk factor for progression to a lower respiratory tract infection and was a major risk factor for TRM. Transplant delay, whenever feasible, in case of a positive NPA screen for VRIs can positively impact on survival of children undergoing HSCT.

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“…The severity of influenza infection depends mainly on the type of influenza virus and the status of the patient's immune system [34], since cancer patients who receive bone marrow or stem cell transplants have decreased immune and poor responses to influenza vaccines [35, 36]. In our study, we have demonstrated that BM CD4 + TSCMs that could help the maturation of antibodies against influenza were very important for anti-influenza immune.…”

Section: Discussionmentioning

confidence: 63%

CD4⁺ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Wang

Guo

et al. 2019

Mediators of Inflammation

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The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122high stem cell antigen-1 (Sca-1) high B cell lymphoma 2 (Bcl-2) high CD4+ stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4+ TSCMs homing to the BM colocalized with VCAM-1+ IL-15+ IL-7+ CXCL-12+ stromal cells. Furthermore, compared to spleen-resident CD4+ TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4+ TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4+ T lymphocytes.

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Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology–oncology patients

Cited by 3 publications

References 15 publications

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality

CD4⁺ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

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Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology–oncology patients

Cited by 3 publications

References 15 publications

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency

Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality

CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

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CD4⁺ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice