How reliable an indicator of inflammation is myeloperoxidase activity?

Faith, Minnie; Sukumaran, Abitha; Pulimood, Anna; Jacob, Molly

doi:10.1016/j.cca.2008.06.016

Cited by 89 publications

(63 citation statements)

References 16 publications

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“…[19] In our experimental study, we showed a reduction in the activity of the enzyme MPO in the renal tissue of the rats in the NStreated group as compared with rats in the control group. In a similar manner, histological analyses showed less inflammatory infiltrate in kidneys of the rats in the treated group.…”

Section: Discussionmentioning

confidence: 53%

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

et al. 2010

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Section: Discussionmentioning

confidence: 53%

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

et al. 2010

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“…In this study, the additive increased mammary concentrations of MPO and MHC mRNAs. Myeloperoxidase is involved in generation of reactive oxygen species in neutrophils and therefore serves as a reliable marker of neutrophil infiltration into a tissue and inflammation (Faith et al, 2008). An increase in mammary MPO mRNA implies that the additive may have enhanced the inflammatory response of mammary tissue to the E. coli challenge.…”

Section: Discussionmentioning

confidence: 99%

Effects of an immunomodulatory feed additive on the development of mastitis in a mouse infection model using four bovine-origin isolates

Rowson¹,

Wang²,

Aalseth

et al. 2011

Animal

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The goal of this study was to examine the ability of a commercially available feed additive (OmniGen-AF) to reduce mammary infections caused by a single strain of mastitic pathogens (Streptococcus uberis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae) and to examine the effects of the additive on markers of mammary immunity. Four experiments were completed using a murine model of bovine mastitis. Infection progression was examined using Sybr-green-and TaqMan-based quantitative PCR assays of 16S ribosomal DNA. Infection of the mammary gland with all pathogens caused rapid (24 to 48 h) appearance of pathogen DNA in mammary tissue. Provision of the feed additive for 2 weeks before infection significantly (P , 0.05) reduced the extent of pathogen DNA accumulation in models of S. uberis, E. coli and S. aureus infection. The additive was ineffective in reducing mammary infections caused by K. pneumoniae. We examined mechanisms of action of the additive through assessment of mammary concentrations of mammary myeloperoxidase (MPO), major histocompatibility complex 2 class II (MHC) and macrophage inflammatory protein-1a (MIP) messenger RNA (mRNA) concentrations and by examining serum complement C3 concentration. Infection of the mammary gland increased concentrations of MPO and MHC mRNAs (P , 0.05). Ability of the pathogen to elicit changes in mammary MPO and MHC gene expression was enhanced by the provision of the additive for 2 weeks before infection. These data imply that the additive increased the mammary inflammatory response and increased antigen presentation during a mammary infection. Value of the additive in preventing mastitis in cattle awaits additional studies using a bovine model and further evaluation of additional strains of the pathogens used in this study.

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“…Among new inflammatory markers, the enzyme myeloperoxidase (MPO) has been recently accentuated [2,3]. However, its plasma level and/or changes in level in the case of inflam mation-driven diseases like JIA remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)

et al. 2010

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AbstractTo examine the plasma levels of MPO in oligoarthritis and polyarthritis subtypes of JIA in comparison with healthy age-matched controls. Thirty-eight JIA patients (25 girls and 13 boys) aged 9.1–11.8 years and 23 healthy controls (8 girls and 15 boys) participated in the study. Twenty-one patients had oligoarthritis (8 with extended oligoarthritis) and 17 had polyarthritis (among them three were seropositive). The plasma concentration of MPO was measured by the ELISA technique (OxisResearchTM, BIOXYTECH® MPO-EIATM, Portland, OR USA). The mean plasma concentration of MPO in the JIA group was significantly higher than in the control group (76.6±24.8 µg/L versus 62.7±15.6 µg/L; p=0.01). Patients with polyarthritis presented a significantly higher mean plasma MPO level than patients with oligoarthritis (81.3±25.6 µg/L and 62.1±27.1 µg/L, respectively; p=0.02). Different subtypes of JIA may have different MPO-related backgrounds. MPO is a new potent inflammatory marker. Patients with polyarthritis have higher mean plasma MPO levels than patients with oligoarthritis and may therefore have an enhanced risk for subclinical oxidative stress-related atherogenic promotion.

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How reliable an indicator of inflammation is myeloperoxidase activity?

Cited by 89 publications

References 16 publications

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

Effects of an immunomodulatory feed additive on the development of mastitis in a mouse infection model using four bovine-origin isolates

Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)

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