2006
DOI: 10.1016/j.carres.2006.09.019
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Hyaluronan degradation by copper(II) chloride and ascorbate: rotational viscometric, EPR spin-trapping, and MALDI–TOF mass spectrometric investigations

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Cited by 30 publications
(14 citation statements)
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References 38 publications
(40 reference statements)
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“…High molecular weight hyaluronan samples were exposed to free-radical chain degradation reactions induced by ascorbate in the presence of Cu(II) ions, the so called Weissberger's oxidative system. The concentrations of both reactants [ascorbate, Cu(II)] were comparable to those that may occur during an early stage of the acute phase of joint inflammation (see Figure 6) (Banasova et al, 2011; Valachova et al, 2011; Soltes et al, 2006a; Soltes et al, 2006b; Stankovska et al, 2004; Soltes et al, 2006c; Soltes et al, 2007; Valachova et al, 2008; 2009; 2010; 2011; 2013; Hrabarova et al, 2009, 2011; Rapta et al, 2009; 2010; Surovcikova-Machova et al, 2012; Banasova et al, 2011; Drafi et al, 2010; Fisher & Naughton, 2005). …”
Section: Hyaluronan and Synovial Fluidmentioning
confidence: 52%
“…High molecular weight hyaluronan samples were exposed to free-radical chain degradation reactions induced by ascorbate in the presence of Cu(II) ions, the so called Weissberger's oxidative system. The concentrations of both reactants [ascorbate, Cu(II)] were comparable to those that may occur during an early stage of the acute phase of joint inflammation (see Figure 6) (Banasova et al, 2011; Valachova et al, 2011; Soltes et al, 2006a; Soltes et al, 2006b; Stankovska et al, 2004; Soltes et al, 2006c; Soltes et al, 2007; Valachova et al, 2008; 2009; 2010; 2011; 2013; Hrabarova et al, 2009, 2011; Rapta et al, 2009; 2010; Surovcikova-Machova et al, 2012; Banasova et al, 2011; Drafi et al, 2010; Fisher & Naughton, 2005). …”
Section: Hyaluronan and Synovial Fluidmentioning
confidence: 52%
“…These tenets, i -iii, and especially the last one have been unequivocally established by using the EPR spectroscopy [20]. At the later time interval ( > 60 min), however, as confirmed by the EPR, the HO .…”
mentioning
confidence: 93%
“…For detection of such AOOH and/or AOH type derivatives, the non-isothermal chemiluminometry and MALDI-TOF mass spectrometry could be proposed as relevant analytical methods (Šoltés et al ., 2006; 2007; Rychlý et al ., 2006). …”
Section: Discussionmentioning
confidence: 99%
“…Scheme 1, Fisher and Naughton, 2003; 2004; 2005) and, taking into account the fact that ascorbate reduces Cu(II) to cuprous ions, it is feasible to assume that at copper-catalyzed ascorbate auto-oxidation, ·OH radicals should be generated by a Fenton-type reaction Cu(I) + H 2 O 2 → Cu(II) + ·OH + HO – . This conclusion was recently supported by an unambiguous proof of production of hydroxyl radicals in a system comprising ascorbate plus CuCl 2 by using EPR spin-trap technique, applying such spin traps as 5,5-dimethyl-1-pyrroline- N -oxide (DMPO) and 5-(diisopropoxyphosphoryl)-5-methyl-1-pyrroline- N -oxide (DIPPMPO) (Šoltés et al ., 2006). …”
Section: Introductionmentioning
confidence: 99%