Hyperadrenocorticism in Cats

Feldman, Edward C

doi:10.1016/b978-1-4557-4456-5.00011-0

Cited by 35 publications

(90 citation statements)

References 103 publications

(132 reference statements)

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“…Hypercortisolism was diagnosed based on failure to suppress cortisol concentrations to <1.4 μg/dL at 8 hours on the LDDS, a UCCR >13 × 10 −6 , or a post‐ACTH serum cortisol >22 μg/dL . After a diagnosis of hypercortisolism, PDH was confirmed by measurement of endogenous ACTH (eACTH) or cortisol concentrations.…”

Section: Methodsmentioning

confidence: 99%

“…After a diagnosis of hypercortisolism, PDH was confirmed by measurement of endogenous ACTH (eACTH) or cortisol concentrations. ACTH concentration >40 pg/mL and/or >50% suppression of serum cortisol concentration during the course of the LDDS were considered diagnostic of PDH . All assays were performed by a commercial clinical veterinary laboratory (Antech Diagnostics, Irvine, CA).…”

Section: Methodsmentioning

confidence: 99%

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Transsphenoidal surgery using a high definition video telescope for pituitary adenomas in dogs with pituitary dependent hypercortisolism: Methods and results

2014

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Transsphenoidal surgery using a high definition video telescope for pituitary adenomas in dogs with pituitary dependent hypercortisolism: Methods and results

2014

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“…Long-term excessive cortisol concentrations may induce immunosuppression and predispose dogs to generalized demodicosis [3,10]. In this study, 12 consecutive weekly applications of spot-on moxidectin/imidacloprid were well tolerated by these metabolism-compromised dogs, with no reported side effect and no abnormality detected by routine blood tests.…”

Section: Discussionmentioning

confidence: 82%

“…Hyperadrenocorticism (HAC) is a common canine endocrine disorder characterized by chronically elevated circulating concentrations of the steroid hormones produced by the adrenal cortex [10]. Immunosuppression is a common complication associated with long-term hyperadrenocorticism, which renders dogs prone to the development of secondary demodicosis and is often problematic and might be intractable [3].…”

Section: Introductionmentioning

confidence: 99%

Treatment of canine generalized demodicosis associated with hyperadrenocorticism with spot-on moxidectin and imidacloprid

Huang

Lien²

2013

Acta Vet Scand

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BackgroundCanine generalized demodicosis associated with hyperadrenocorticism is often problematic and might be intractable. The aim of this study was to report the efficacy of a weekly application of spot-on moxidectin/imidacloprid in dogs with hyperadrenocorticism and secondary generalized demodicosis.MethodsDogs with hyperadrenocorticism and secondary generalized demodicosis were included. The condition of hyperadrenocorticism was treated and stabilized with trilostane before and throughout the study period in all dogs.ResultsAverage total live adult mite counts before treatment and after four, eight and 12 weeks of spot-on moxidectin/imidacloprid (2.5/10 mg/kg) applications were 20.1 ± 6.3 (range, 13–33), 0.5 ± 0.7 (range, 0–2; 6/11 were negative), 0.2 ± 0.4 (range, 0–1; 9/11 were negative), 0.2 ± 0.4 (range, 0–1; 9/11 were negative) and 0.1 ± 0.3 (range, 0–1; 10/11 were negative) respectively; this difference was significant (P < 0.001). Ten of 11 dogs (90.1%) achieved clinical remission, as demonstrated by the absence of demodectic mites at any life stage at monthly scrapings for eight consecutive weeks, and maintained remission throughout the 12-month follow-up period.ConclusionThe weekly application of spot-on moxidectin/imidacloprid appeared to be effective and safe against generalized adult onset canine demodicosis associated with hyperadrenocorticism.

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“…75,76 Approximately 50% of the adrenal tumors are adenomas and 50% are carcinomas. However, both PDH and adrenal tumors (adrenocortical adenomas and carcinomas) have been described, and the findings are similar to those of dogs 72-75 (see .…”

Section: Adrenal Gland Pathology In the Catmentioning

confidence: 99%