Hyperkeratosis in Response to Mechanical Irritation**From the Section of Dermatology, School of Medicine, University of Chicago, Chicago, Illinois (Chief of Service: Stephen Rothman, M.D.)

Rubin, Louis

doi:10.1038/jid.1949.102

Cited by 28 publications

(2 citation statements)

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“…During hyperkeratosis dermal and epidermal cells react to stress by generating inflammatory cytokines which cause the incomplete differentiation of corneocytes. This accelerates transit through the epidermis, rendering the SC biochemically and structurally compromised [2]. Examples include the incomplete degradation of desmosomes and abnormal lipid layer formation, which lead to altered corneocyte adhesion and desquamation, and SC thickening [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Characterising the biophysical properties of normal and hyperkeratotic foot skin

Hashmi

Nester

Wright

et al. 2015

Journal of Foot and Ankle Research

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BackgroundPlantar foot skin exhibits unique biophysical properties that are distinct from skin on other areas of the body. This paper characterises, using non-invasive methods, the biophysical properties of foot skin in healthy and pathological states including xerosis, heel fissures, calluses and corns.MethodsNinety three people participated. Skin hydration, elasticity, collagen and elastin fibre organisation and surface texture was measured from plantar calluses, corns, fissured heel skin and xerotic heel skin. Previously published criteria were applied to classify the severity of each skin lesion and differences in the biophysical properties compared between each classification.ResultsCalluses, corns, xerotic heel skin and heel fissures had significantly lower levels of hydration; less elasticity and greater surface texture than unaffected skin sites (p < 0.01). Some evidence was found for a positive correlation between hydration and elasticity data (r ≤ 0.65) at hyperkeratotic sites. Significant differences in skin properties (with the exception of texture) were noted between different classifications of skin lesion.ConclusionsThis study provides benchmark data for healthy and different severities of pathological foot skin. These data have applications ranging from monitoring the quality of foot skin, to measuring the efficacy of therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Characterising the biophysical properties of normal and hyperkeratotic foot skin

Hashmi

Nester

Wright

et al. 2015

Journal of Foot and Ankle Research

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“…Hyperkeratotic lesions (calluses and corns) is defined as thickening of the cuticle of the epidermis produced by hyperplasia or hypertrophy of its own cells (Rubin 1949). Plantar hyperkeratotic lesions are very widespread among the older population, affecting 30-65% of seniors aged over 65 years (Dunn et al 2004;Araguas García et al 2017).…”

Section: Plantar Hyperkeratotic Lesionsmentioning

confidence: 99%

A Current Review of Foot Disorder and Plantar Pressure Alternation in the Elderly

Zhang

2020

Physical Activity and Health

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Fall is a very common injury, especially in older adults with foot deformities and other foot disorders. Even a small fall may cause fatal damage to this cohort. The purpose of this study was to conduct a review elucidating plantar pressure pattern under different foot deformities in the elderly. English-language search of the electronic databases in PubMed, ScienceDirect, Google Scholar, and Web of Science was conducted from 2000 to May 2020. Fifteen studies were found after literature searching and screening. Among them, 2 studies described the plantar pressure of plantar hyperkeratosis lesions in the elderly, 2 studies depicted the plantar pressure of pronated foot supinated foot in the elderly, 4 studies explored the plantar pressure distribution of hallux valgus and other foot deformities, and 7 studies focused on the plantar pressure of diabetic foot deformity in the elderly. Foot deformity appears to alter the plantar pressure in the elderly, and plantar pressure characteristics differ according to foot deformities.

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Effects of Frictional Stimulation on the Structure of the Stratum Corneum

Mackenzie

1983

Stratum Corneum

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Hyperkeratosis in Response to Mechanical Irritation**From the Section of Dermatology, School of Medicine, University of Chicago, Chicago, Illinois (Chief of Service: Stephen Rothman, M.D.)

Cited by 28 publications

References 3 publications

Characterising the biophysical properties of normal and hyperkeratotic foot skin

Characterising the biophysical properties of normal and hyperkeratotic foot skin

A Current Review of Foot Disorder and Plantar Pressure Alternation in the Elderly

Effects of Frictional Stimulation on the Structure of the Stratum Corneum

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