Hyperpolarized 3He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease

Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized 129Xe MR Imaging

“…The average ADC at whole-lung ranging from reader-based scoring (11), manual segmentation (12), and semiautomated segmentation (13) to fully automated segmentation (14). The feasibility of lobar and bronchopulmonary segmental ventilation assessment with hyperpolarized 3 He MR imaging has been reported in healthy volunteers and subjects with asthma (15,16).…”

Assessment of Regional Lung Function with Multivolume1H MR Imaging in Health and Obstructive Lung Disease: Comparison with3He MR Imaging

“…We note that the functional effects of gas trapping due to airway obstruction and emphysema will both result in low or no change in proton signal with volume and low to no 3 He ventilation. 3 He MR imaging has been successful at demonstrating high-resolution ventilation imaging in obstructive pulmonary diseases (39,40), but high costs and the non-Food and Drug Administration-approved gas tracers have restricted its translation to the clinic. On the contrary, we propose a method based on straightforward pulse sequences and hardware that simply measures the regional amplitude of proton signal change between different lung volumes with no requirement for any gaseous tracers.…”

Imaging phenotypes of chronic obstructive pulmonary disease

“…Thus, there is almost no information about these affected lung regions. Most of the studies on 3 He MRI used a 1.5T system; however, the first studies demonstrated the feasibility to perform these measurements also at a higher field strength (3T) (68). The field of hyperpolarized noble gas imaging is currently undergoing some changes due to supply issues of 3 He, while development of 129 Xe are increasingly encouraging due to novel polarizer systems that offer higher levels of polarization and thus better signal (69,70).…”