Hypertension due to hypernephroma.

Ram, M D; Chisholm, G. D.

doi:10.1136/bmj.4.5675.87

Cited by 19 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hipertansiyon tipik olarak berrak hücreli histolojiye sahip düşük dereceli tümörler ile bağlantılıdır. Bu bağlantıyı açıklamaya yönelik yapılan çalışmalar RHK'lı hastalardaki hipertansiyonun nedenini ve prognozunu net olarak ortaya koymada başarısız olmuştur (22,23,24). Bu hastalarda hipertansiyonun potansiyel mekanizmaları olarak artmış renin salgılanması, üreteral obstrüksiyon, parankimal bası varlığı, arteriyovenöz fistül ve polisitemi düşünülmelidir (23,24,25).…”

Section: Hiperkalsemiunclassified

“…RHK'lı hastaların %37'sinde yükselmiş plazma renin seviyeleri saptanmıştır (26,27,28). Neoplastik proksimal tübül hücrelerinin renin salgıladığı immüno-histokimyasal çalışmalarla gösterilmiştir (22). Bunun yanı sıra lokal renal parankim basısı, subkapsüler hematom veya büyük tümörler de intrarenal iskemiye sebep olarak renin salınımı artışına sebep olmaktadır (29).…”

Section: Hiperkalsemiunclassified

See 1 more Smart Citation

Renal Hücreli Kanserde Paraneoplastik Sendromlar

İzol¹,

Kaplan²

2014

uob

View full text Add to dashboard Cite

Genitoüriner kanserler arasında renal hücreli karsinom, hastaların yaklaşık üçte birinde paraneoplastik sendroma ait semptom ve bulguların görülebilmesiyle kendini gösteren bir patolojidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromlar konstitüsyonel semptomları (örneğin; ateş, kaşeksi ve kilo kaybı) ve bunun yanı sıra spesifik metabolik ve biyokimyasal anormallikleri (örneğin; hiperkalsemi, nonmetastatik hepatik disfonksiyon, amiloidoz vb.) içermektedir. Paraneoplastik sendrom varlığı ne metastatik hastalık işareti ne de kötü prognoz göstergesidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromların patofizyolojisi ve biyolojisinin anlaşılmasıyla birlikte, konstitüsyonel semptomlar veya metabolik anormallikler primer veya tekrarlayan hastalığın ilk belirtisi olabilir. Bu hastalarda, paraneoplastik sendromların doğru tanısı ve yönetimi hastaların palyatif tedavisinde önemli olabilir. RHK ile ilgili kaşeksi, ateş, karaciğer fonksiyon bozukluğu, anemi ve amiloidoz gibi paraneoplastik belirtilerin patofizyolojisi henüz tam olarak aydınlatılamamıştır. Hiperkalsemi dışındaki paraneoplastik sendromlarda geleneksel medikal tedaviler nadiren faydalıdır. Erken tanı ve etkin tedavi bu hastaların yaşam kalitesini ve prognozunu değiştirebilir. Bu derlemede, renal hücreli karsinom ile ilgili birçok paraneoplastik sendromun ortaya çıkış mekanizmalarıyla birlikte, bunların klinik yansımalarını ve bu önemli bozukluklar için mevcut tedavi seçeneklerini tartışacağız. (Üroonkoloji Bülteni 2014;13:130-134) Anah tar Ke li me ler: Paraneoplastik sendrom, renal hücreli kanser, hiperkalsemi Renal cell carcinoma which is among genitourinary cancers is a pathology presenting with signs and symptoms of paraneoplastic syndrome in almost one third of the affected patients. The paraneoplastic syndromes associated with renal cell carcinoma include constitutional symptoms (ie, fever, cachexia, and weight loss), as well as specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a paraneoplastic syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease nor necessarily indicative of a poor prognosis. The importance of understanding the pathophysiology and biology behind the many paraneoplastic syndromes associated with renal cell carcinoma lies in the fact that the presence of these protean symptoms may be the initial presentation of either primary or recurrent disease. In these patients, the accurate diagnosis and management of paraneoplastic syndromes may be important in palliative management. Pathophysiology of paraneoplastic symptoms of RCC such as cachexia, fever, hepatic dysfunction, anemia, and amyloidosis, remains incomplete. Except for hypercalcemia, conventional medical therapies are seldom helpful in the treatment of paraneoplastic symptoms. An early diagnosis and effective treatment might improve quality of life and alter prognosis of these patients. In this review, we will describe the proposed...

show abstract

Section: Hiperkalsemiunclassified

Renal Hücreli Kanserde Paraneoplastik Sendromlar

İzol¹,

Kaplan²

2014

uob

View full text Add to dashboard Cite

show abstract

“…Some of these patients may be candidates for nephrectomy, since cure of hypertension after the invervention has been well documented in a consider able number [1,2]. Normal blood pressure after reconstructive or ablative surgery has also been reported in patients with unilateral hydronephrosis, simple renal cysts, traumatic kidney lesions and renal tumors with hyper tension [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of hypertension in patients with hypernephroma ranges from less than 10 to 50% [6,57]. In a consecutive series of 50 patients with hypernephroma, hypertension was the only physical symptom in 12.5% [57].…”

Section: Renal Tumors Causing Hypertensionmentioning

confidence: 99%

“…Renal hypertension may occur in patients with hemangiopericytoma, Wilm's tumor (nephroblastoma) and less frequently in pa tients with hypernephroma and carcinoma of the renal pelvis [6,[55][56][57][58], Renal tumors may cause hypertension either by directly secreting renin or by an indirect activation of the renin angiotensin system. Hemangiopericytomas are very rare be nign renal tumors arising from the cells of the juxtaglomerular apparatus.…”

Section: Renal Tumors Causing Hypertensionmentioning

confidence: 99%

See 1 more Smart Citation

Curable Renal Parenchymatous Hypertension: Current Diagnosis and Management

Lüscher¹,

Wanner²,

Hauri

et al. 1985

Cardiology

View full text Add to dashboard Cite

Unilateral parenchymatous kidney disease associated with high blood pressure represents a potentially curable form of hypertension. Surgery may normalize blood pressure in a substantial number of these patients. Curable renal parenchymatous hypertension includes unilateral tubulointerstitial kidney diseases such as chronic pyelonephritis, reflux nephropathy, segmental hypoplasia and radiation nephritis, hydronephrosis, simple renal cysts, traumatic kidney lesions and renal tumors associated with high blood pressure. Renal ischemia and in turn activation of the renin angiotensin system is involved in the pathogenesis of hypertension in most of these patients. In patients with unilateral kidney disease and hypertension, both an operative and a medical therapeutic approach have a high success rate. Good candidates for nephrectomy are young patients with severe hypertension, strict unilateral disease, normal plasma creatinine levels and minimal function of the involved kidney. In unilateral hydronephrosis reconstructive surgery or nephrectomy may cure or improve hypertension in the vast majority of the patients. Surgically correctable hypertension has also been reported in some patients with large renal cysts and renal tumors (hemangiopericytoma, Wilm’s tumor, hypernephroma, renal pelvic tumor).

show abstract

Hypertension with renal carcinoma an effect of arterial embolization

Alavi

McLean

2006

Cancer

View full text Add to dashboard Cite

A patient presented with mediastinal metastases from renal adenocarcinoma. Palliative therapy included Gelfoam and steel coil embolization of the right renal artery. Six weeks later he was found to have developed severe hypertension. Arteriogram revealed collateral vessels which supplied the tumor; the renal vein renin activity was four times higher on the right than on the left. We suspect that infarction of the kidney was not complete because of collateral arterial supply, and renin‐dependent hypertension was the result. Thus, it may be hazardous to embolize large hypernephromas without subsequent nephrectomy. Cancer 52:169‐172, 1983.

show abstract

Hypertension due to hypernephroma.

Cited by 19 publications

References 3 publications

Renal Hücreli Kanserde Paraneoplastik Sendromlar

Renal Hücreli Kanserde Paraneoplastik Sendromlar

Curable Renal Parenchymatous Hypertension: Current Diagnosis and Management

Hypertension with renal carcinoma an effect of arterial embolization

Contact Info

Product

Resources

About