Hypertonic Saline and Acute Wheezing in Preschool Children

Abstract

Using HS inhalations significantly shortens LOS and lowers AR in preschool children presenting with an acute wheezing episode to the emergency department.

Comparing the efficacy of 7%, 5% hypertonic saline and 0.9% normal saline in acute bronchiolitis: a randomized controlled trial

“…[8][9][10][11][12][13][14][15][16][17][18][19] Many studies showed that 5% HS in treatment of bronchiolitis in children is better than 0.9% NS. 8,20,21 Jacobs et al, conducted a clinical trial and showed that use of 7% HS with epinephrine did not have a considerable effect on the severity and LOS of the infants under 18 months with viral bronchiolitis which not in line with our study results. 22 All children in this study well tolerated the treatment and it was predictable because previous studies had shown that 7% and 5% HS are well tolerated by patients.…”

Asthma‐predictive‐index, bronchial‐challenge, sputum eosinophils in acutely wheezing preschoolers

“…A flow chart of the study patients is given in Figure . Forty‐one children (age 31.9 ± 17.4 months, range; 1–6 years), recruited during January 2009 to January 2011 to another study (a double blind controlled study looking at the effect of hypertonic saline compared with normal saline on wheezing preschoolers presenting to the ED) were included for this study. Inclusion criteria: children 1‐ to 6‐year‐old presenting to Wolfson Medical Center with acute wheezing illness with a clinical score ≥6 .…”

Managing wheeze in preschool children

“…38 Admission rates and lengths of stay were significantly reduced in the hypertonic saline group, but there was no significant change in severity score, possibly because of the small size of the study. Further work in larger numbers of children is needed to define the role of hypertonic saline in acute preschool wheeze.…”