Hypolipidemic activity of ethanolic extract of Caulerpa recemosa

Abstract

Background: Caulerpa recemosa, also known as sea grape, is a stout straggling prostrate shrubby plant with spinous stipules and uniaxial siphonous thallus, mostly divided into a creeping axis (stolon), with rhizoids and erect shoots (fronds), either nude, leaf-like or with grape or feather-like ramuli. Caulerpa racemosa has erect fronds up to 9-13 cm high bearing un-crowded vesiculate ramuli that are radially arranged. Fronds are slightly inflated above the attachment to the stolon which are fixed to the substrate by thin short rhizoids. It is collected from St. Martin’s Island locally called ‘Narikel Jinjira’, located on the southernmost tip of Bangladesh for the present study, ethanol extract of Caulerpa recemosa has been screened for its hypolipidemic activity.
 Methods: Hypolipidemic activity was screened by inducing hyperlipidemia with the help of atherogenic diet in wistar albino rats and serum levels of various biochemical parameters such as total cholesterol, triglycerides, low density lipoprotein and high density lipoprotein cholesterol were determined. Atherogenic index shows the measure of the atherogenic potential of the drugs.
 Results: Ethanol extract showed significant (p < 0.01) hypolipidemic effect by lowering the serum levels of biochemical parameters such as significant reduction in the level of serum cholesterol, triglyceride, low density lipoprotein and increase in high density lipoprotein level which was similar to the standard drug atorvastatin. Ethanol extract exhibited significant atherogenic index andpercentage protection against hyperlipidemia. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as steroids, flavonoids, glycosides, alkaloids, phenoliccompounds.
 Conclusion: The overall experimental results suggest that the biologically active phytoconstituents such as flavonoids, glycosides alkaloids present in the ethanolic extract of Caulerpa racemosa may be responsible for the significant hypolipidemic activity and the results may justify the use of Caulerpa racemosa as a significant hypolipidemic agent.
 Birdem Med J 2019; 9(3): 197-201

Production, Phytochemical Characterization and Acceptability of Wines from Green Seaweeds (Halimeda macroloba, Caulerpa sertularioides and Caulerpa racemosa)

“…Rajasekar et al [33] reported that betacyanin was found to be present in green seaweeds. Other studies [34,35,36] found that C. racemosa possess alkaloids, flavonoids, glycosides, phenols, saponins and steroids, however, these secondary metabolites were not detected qualitatively in the ethanolic extract of our samples. The differences in results could be attributed to some factors like climatic condition, season, species, subspecies, harvest and the method used for extraction of compounds which greatly affects the chemical compositions of the extract [37].…”

Lipid Extracts from Caulerpa lentillifera Waste: An Alternative Product in a Circular Economy

“…Sharma et al [40] found that the ethanolic extract of C. okamurae was effective in preventing body weight gain and fat accumulation and reduced plasma and hepatic lipid profiles. Likewise, Rahman et al [41] reported that the ethanolic extract of C. recemosa could potentially be used as a hypolipemic agent since it exhibited a significant hypolipemic effect at a dose of 200 mg/kg body weight. Based on this information, lipid extracts from Caulerpa have the potential as a food supplement or agent for good health that might be beneficial for aging societies and people with diabetes or hyperlipidemia.…”

Karakteristik Kimia Rumput Laut Hijau (Caulerpa racemosa & Caulerpa taxifolia) dari Laut Natuna, Kepulauan Riau, Indonesia

“…Menurut Gambar 1 Lokasi pengambilan sampel rumput laut Iveša et al (2004), C. taxifolia memiliki proporsi asam lemak jenuh berkisar antara 45,2-73,7%, asam lemak tak jenuh tunggal 10,3-25,9% dan tak jenuh ganda sebesar 16-34,3%. Caulerpa racemosa memiliki kandungan seperti terpenoid, asam lemak poliasetilenik, saponin, steroid, alkaloid, tanin, tirosin, glikosida, kumarin, phlobatannin, karbohidrat, flavonoid dan protein, serta caulerpin (Nurjanah et al, 2016;Kumar et al, 2019;Rahman et al, 2019;Subramanian et al, 2019).…”

“…Rumput laut C. taxifolia dan C. racemosa memiliki aktifitas farmakologis antiproliferatif, antivirus, antikoagulan, antioksidan, antiradang, antimikroba, antijamur, antikanker dan antirematik (Sumanya et al, 2015;Ramakrishnan et al, 2015;Ferramosca et al, 2016;Rahman et al, 2019). Hasil penelitian Nagappan & Vairappan (2014) menunjukkan bahwa C. racemosa mengandung senyawa fenol sebagai komponen non gizi.…”