Hypomethylated gene NRP1 is co-expressed with PDGFRB and associated with poor overall survival in gastric cancer patients

Wang, Guanghui; Shu, Bin; Fu, Yunong; Zhao, Shasha; Qu, Kai; Guo, Qingbo; Li, Ké; She, Junjun

doi:10.1016/j.biopha.2019.01.023

Cited by 32 publications

(32 citation statements)

References 30 publications

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“…In this study, based on the result predicted by bioinformatics analysis that NRP1 has stable binding sites with miR-653-5p and miR-338-3p, NRP1 was selected as the common downstream target gene, and the result proved miR-653-5p and miR-338-3p mimics downregulated NRP1 expression, further confirmed this prediction. Although the study of NRP1 in GC remained limited, it was reported that the high expression of NRP1 due to hypomethylation was co-expressed with PDGFRB and was significantly correlated with tumor malignant phenotypes with poor prognosis (48). Similarly, we also found that NRP1-KD restrained the migration and invasion capability of HRGC cells, and NRP1 was involved in circHIPK3 promotion of HRGC metastasis by the sponging with miR-653-5p and miR-338-3p, suggesting the metastatic promotion role of NRP1 in GC under a long-term hypoxic microenvironment.…”

Section: Discussionmentioning

confidence: 99%

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Jin

Che

et al. 2020

Front. Oncol.

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Section: Discussionmentioning

confidence: 99%

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Jin

Che

et al. 2020

Front. Oncol.

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“…The 43 genes with similar expression patterns are likely to have related functions in the aggressive growth and metastasis of cancers (64). In the PPI network, the genes of AEBP1, MMP14, OLFML2B, PDGFRB, SERPINE1, SPARC, SFRP2, COL1A2, COL6A3, THBS2, COL5A2, COL11A1, FAP, MXRA5 and THY1 were upregulated in solid cancer tissues, and significantly associated with the overall survival of patients with cancer (74)(75)(76)(77)(78)(79)(80)(81)(82). Some genes in the PPI network, including AEBP1, OLFML2B, PDGFRB, SERPINE1, COL1A2, COL6A3, and THBS2 have been reported to be associated with metastasis, invasion and migration in cancer cells (74,76,80,83,84).…”

Section: Discussionmentioning

confidence: 99%

Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers

Zhao

Yin

Zhao³

et al. 2020

Oncol Lett

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Biglycan (BGN), a key member of the small leucine-rich proteoglycan family, is an important component of the extracellular matrix. Clinical studies have demonstrated that upregulation of BGN is associated with poor prognosis in patients with various types of solid cancer. The present study analyzed the mRNA expression levels of BGN in various types of solid cancer when compared with that in normal tissues via the Oncomine database. The UALCAN, OncoLnc and Kaplan-Meier Plotter databases were additionally used to evaluate the prognostic values of BGN in patients with solid cancer and co-expression gene analysis was conducted using the protein-protein interaction networks of BGN. The present study observed that the mRNA expression levels of BGN were increased in bladder, brain and central nervous system, breast, colorectal, esophageal, gastric, head and neck, lung, ovarian and 28 subtypes of cancer compared with normal tissues. The increased expression of BGN was identified to be associated with a poor outcome in ovarian and gastric cancer. Based on the co-expression network, BGN was identified as the key gene in a 43-gene network. The present findings of increased expression of BGN in solid tumors and its positive association with poor outcome on patient survival indicate that BGN may serve as a prognostic marker and as a target for novel therapeutics for multiple types of cancer.

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“…Recent studies highlight that RAI14 was up-regulated in gastric cancer associated with the patient's prognosis and RAI14 knockdown by siRNA interference reduced proliferation and migration, promoted apoptosis through inhibiting the activation of Akt signaling pathway in gastric cancer [34,35]. Wang et al [36] proved that NRP1 was a hypomethylated-upregulated gene in GC patients, which was significantly correlated with tumor malignant phenotypes. The expression level of NRP1 was significantly associated with the overall survival of GC patients.…”

Section: Discussionmentioning

confidence: 99%

A methylation‐based mRNA signature predicts survival in patients with gastric cancer

Sun

Zhang

et al. 2020

Cancer Cell Int

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Background: Evidence suggests that altered DNA methylation plays a causative role in the occurrence, progression and prognosis of gastric cancer (GC). Thus, methylated-differentially expressed genes (MDEGs) could potentially serve as biomarkers and therapeutic targets in GC. Methods: Four genomics profiling datasets were used to identify MDEGs. Gene Ontology enrichment and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analysis were used to explore the biological roles of MDEGs in GC. Univariate Cox and LASSO analysis were used to identify survival-related MDEGs and to construct a MDEGs-based signature. The prognostic performance was evaluated in two independent cohorts. Results: We identified a total of 255 MDEGs, including 192 hypermethylation-low expression and 63 Hypomethylation-high expression genes. The univariate Cox regression analysis showed that 83 MDEGs were associated with overall survival. Further we constructed an eight-MDEGs signature that was independent predictive of prognosis in the training cohort. By applying the eight-MDEGs signature, patients in the training cohort could be categorized into high-risk or low-risk subgroup with significantly different overall survival (HR = 2.62, 95% CI 1.71-4.02, P < 0.0001). The prognostic value of the eight-MDEGs signature was confirmed in another independent GEO cohort (HR = 1.35, 95% CI 1.03-1.78, P = 0.0302) and TCGA-GC cohort (HR = 1.85, 95% CI 1.16-2.94, P = 0.0084). Multivariate cox regression analysis proved the eight-MDEGs signature was an independent prognostic factor for GC. Conclusion: We have thus established an innovative eight-MDEGs signature that is predictive of overall survival and could be a potentially useful guide for personalized treatment of GC patients.

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Hypomethylated gene NRP1 is co-expressed with PDGFRB and associated with poor overall survival in gastric cancer patients

Cited by 32 publications

References 30 publications

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers

A methylation‐based mRNA signature predicts survival in patients with gastric cancer

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