Hypozincemia in patients with malignant melanoma

Horcicko, J; Pantůček, M.

doi:10.1016/0009-8981(83)90301-7

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…In previous studies, serum Zn concentrations were found to be increased (Siu et al, 1991;Ros-Bullon et al, 1998) or decreased (Horcicko and Pantucek, 1983) in melanoma patients. Since Zn may have pro-oxidant effects, the possibility that an excess exposure to this element or its abnormal metabolism, as previously hypothesized for Cu, might enhance melanoma risk should be considered while explaining our findings.…”

Section: Discussionmentioning

confidence: 84%

Environmental exposure to trace elements and risk of cutaneous melanoma

Bassissi

Malagoli

Pellacani

et al. 2005

J Expo Sci Environ Epidemiol

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Purpose: Our aim was to examine the risk of melanoma in association with exposure to trace elements of toxicological and nutritional interest. Methods: We analyzed the concentrations of cadmium, lead, chromium, selenium, copper and zinc in toenails of 58 patients with newly diagnosed cutaneous melanoma as well as in 58 age-and sex-matched control subjects, randomly selected from the population of Modena province in northern Italy. Results: Melanoma risk was substantially unrelated to toenail levels of cadmium, chromium, lead and selenium. Subjects with higher toenail copper levels showed an excess risk, both in the crude analysis and after adjusting for sun exposure and level of education, while in both analyses high iron concentrations were associated with a decreased risk of the disease. A weak direct association between zinc levels and melanoma risk also emerged in the multivariate analysis. Conclusions: Overall, these results do not suggest an involvement of heavy metals in melanoma etiology, while they do give some support to a possible role of zinc and, in particular, copper and iron exposure in influencing disease risk. However, these findings must be evaluated with caution due to the limited statistical stability of the point estimates.

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Section: Discussionmentioning

confidence: 84%

Environmental exposure to trace elements and risk of cutaneous melanoma

Bassissi

Malagoli

Pellacani

et al. 2005

J Expo Sci Environ Epidemiol

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“…In a US ecological study using state-averaged cancer mortality rate data for Caucasian Americans during 1970–94, indices for dietary zinc were found to be inversely correlated with melanoma mortality rate (183). In a population-based case-control study in the Czech Republic, lower serum zinc concentrations were found among subjects with melanoma (Table 3a) (184). In another case-control study, an inverse association was found between dietary zinc intake and risk of melanoma in Australians (Table 3a) (142).…”

Section: Zincmentioning

confidence: 99%

Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies

Matthews

Fitch

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Exposure to environmental trace elements has been studied in relation to many cancers. However, an association between exposure to trace elements and skin cancer remains less understood. Therefore, we conducted a systematic review of published epidemiologic literature examining the association between exposure to trace elements, and risk of melanoma and keratinocyte carcinoma in humans. We identified epidemiologic studies investigating exposure to arsenic, cadmium, chromium, copper, iron, selenium, and zinc and risk of skin cancer in humans. Among the minerals, arsenic, selenium, and zinc had more than 5 studies available. Exposure to arsenic was associated with increased risk of keratinocyte carcinoma, while too few studies existed on melanoma to draw conclusions. Exposure to selenium was associated with possible increased risk of keratinocyte carcinoma. Studies of zinc and skin cancer were case-control in design and were found to have inconsistent associations. The data on the association between cadmium, chromium, copper, and iron and risk of skin cancer remain too sparse to draw any conclusions. In summary, epidemiologic studies on exposure to trace elements and cutaneous malignancies are limited. Studies with larger sample sizes and prospective designs are warranted to improve our knowledge of trace elements and skin cancer.

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Hyperzincuria and hypozincemia in patients treated with cisplatin

Sweeney

Ziegler

Pruet

et al. 1989

Cancer

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The effect of cis-diamminedichloroplatinum (DDP) on plasma and urinary zinc was studied in fifteen patients with squamous cell carcinoma. A decrease in plasma zinc accompanied by an increase in urinary zinc excretion was observed. Pretreatment plasma or urinary zinc did not correlate with tumor size or site, nor was there a correlation between changes in these measurements and a response to therapy. The enhanced excretion of urinary zinc may be related to a decrease in amino acid resorption in the proximal tubule. It is concluded that DDP administration may result in hyperzincuria and could potentially precipitate a symptomatic zinc deficiency state.

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Hypozincemia in patients with malignant melanoma

Cited by 8 publications

References 14 publications

Environmental exposure to trace elements and risk of cutaneous melanoma

Environmental exposure to trace elements and risk of cutaneous melanoma

Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies

Hyperzincuria and hypozincemia in patients treated with cisplatin

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