<i>Botrytis cinerea</i>alcohol dehydrogenase mediates fungal development, environmental adaptation and pathogenicity

DafaAlla, Tayb Elassma I. M.; Abdalla, Mohnad; El‐Arabey, Amr Ahmed; Eltayb, Wafa Ali; Mohapatra, Ranjan K.

doi:10.1080/07391102.2021.1971112

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…Previous studies show that DEGs such as alcohol dehydrogenase, aldehyde dehydrogenase gene, DNA repair protein, aspartate aminotransferases, and aldo/keto reductase contained in these pathways played a vital role in fungi. For instance, Synechocystis alcohol dehydrogenase sysr1 considerably increases tolerance in salt stress conditions ( Yi et al, 2017 ), and Botrytis cinerea alcohol dehydrogenase BcADH1 is required for fungal development, environmental adaptation, and its ability for full pathogenicity ( DafaAlla et al, 2021 ). ald1 , an aldehyde dehydrogenase gene in the fungus Tricholoma vaccinum , increases its tolerance to ethanol stress ( Asiimwe et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Endophytic Bacterium Serratia plymuthica From Chinese Leek Suppressed Apple Ring Rot on Postharvest Apple Fruit

Sun

Liu

et al. 2022

Front. Microbiol.

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Apple ring rot caused by Botryosphaeria dothidea is an economically significant plant disease that spreads across the apple production areas in China. The pathogen infects apple fruits during the growing season and results in postharvest fruits rot during storage, which brings about a huge loss to plant growers. The study demonstrated that an endophytic bacterium Serratia plymuthica isolated from Chinese leek (Allium tuberosum) significantly suppressed the mycelial growth, severely damaging the typical morphology of B. dothidea, and exerted a high inhibition of 84.64% against apple ring rot on postharvest apple fruit. Furthermore, S. plymuthica significantly reduced the titratable acidity (TA) content, enhanced the soluble sugar (SS) content, vitamin C content, and SS/TA ratio, and maintained the firmness of the fruits. Furthermore, comparing the transcriptomes of the control and the S. plymuthica treated mycelia revealed that S. plymuthica significantly altered the expressions of genes related to membrane (GO:0016020), catalytic activity (GO:0003824), oxidation-reduction process (GO:0055114), and metabolism pathways, including tyrosine metabolism (ko00280), glycolysis/gluconeogenesis (ko00010), and glycerolipid metabolism (ko00561). The present study provided a possible way to control apple ring rot on postharvest fruit and a solid foundation for further exploring the underlying molecular mechanism.

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Section: Discussionmentioning

confidence: 99%

Endophytic Bacterium Serratia plymuthica From Chinese Leek Suppressed Apple Ring Rot on Postharvest Apple Fruit

Sun

Liu

et al. 2022

Front. Microbiol.

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“…For instance, Cytochrome P450s (CYP450) participated in the virulence of Fusarium graminearum ( Shin et al, 2017 ) and Verticillium dahlia ( Zhang et al, 2016 ). Alcohol dehydrogenase (ADH) was required for fungal development, environmental adaptation, and its ability for full pathogenicity in Botrytis cinerea ( DafaAlla et al, 2021 ). Glycoside hydrolase (GHY) functioned as an important determinant of virulence in Coniella vitis ( Qin et al, 2020 ), Phytophthora sojae ( Ma et al, 2015 ), and Pyricularia oryzae ( Pan et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Endophytic bacterium Pseudomonas protegens suppresses mycelial growth of Botryosphaeria dothidea and decreases its pathogenicity to postharvest fruits

Huang

Liu

et al. 2022

Front. Microbiol.

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Apple (Malus domestica Borkh.), one of the most economically important fruits widely consumed worldwide, has been suffering from apple ring rot caused by Botryosphaeria dothidea, which dramatically affects its quality and yield. In the present study, we demonstrated that Pseudomonas protegens, isolated from Chinese leek (Allium tuberosum), significantly suppressed the mycelial growth and propagation of B. dothidea, respectively, further displayed a considerably inhibitory effect on the apple ring rot of postharvest fruits. In addition, P. protegens significantly improved the total soluble solid/titrable acidity (TSS/TA) ratio and soluble sugar/titrable acidity (SS/TA) ratio and drastically maintained the fruit firmness. Further analysis manifested that P. protegens substantially induced the defense-related genes such as MdGLU, MdPAL, MdPOD, MdCAL, and transcription factors related to the resistance to B. dothidea, including MdWRKY15, MdPUB29, MdMyb73, and MdERF11 in apple fruits. Meanwhile, P. protegens considerably restrained the expressions of the pathogenicity-related genes in B. dothidea, including the BdCYP450, BdADH, BdGHY, BdATS, Bdα/β-HY, and BdSTR. By inference, P. protegens inhibited the apple ring rot on postharvest fruits by activating the defense system of apple fruit and repressing the pathogenic factor of B. dothidea. The study provided a theoretical basis and a potential alternative to manage the apple ring rot on postharvest fruits.

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“…A Bcadh1 gene was identified in this organism, encoding a zinc-dependent enzyme. A mutant strain deleted in the referred gene was obtained and characterized [ 36 ]. It was observed that, compared to the wild-type strain, the Δ bcadh1 mutant showed several phenotypic alterations, including a reduced growth capacity in low oxygen tension, greater tolerance to ethanol, and sensitivity to reactive oxygen species.…”

Section: Physiological Role Of Adh In Fungal Cellsmentioning

confidence: 99%

“…The increased ethanol tolerance of the Δ bcadh1 mutant indicated that the enzyme is involved in the fermentation of glucose to ethanol. However, the phenotypic characteristic that best explains this physiological role of the enzyme is the lower growth capacity in low oxygen tension [ 36 ].…”

Section: Physiological Role Of Adh In Fungal Cellsmentioning

confidence: 99%

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Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential

Gutiérrez-Corona,

González-Hernández,

Padilla-Guerrero

et al. 2023

Cells

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Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. These processes are associated with metabolic operation routes related to alcohol, aldehyde, and acid production. The number of ADH enzymes, their metabolic roles, and their functions vary within fungal species. The most studied ADHs are associated with ethanol metabolism, either as fermentative enzymes involved in the production of this alcohol or as oxidative enzymes necessary for the use of ethanol as a carbon source; other enzymes participate in survival under microaerobic conditions. The fast generation of data using genome sequencing provides an excellent opportunity to determine a correlation between the number of ADHs and fungal lifestyle. Therefore, this review aims to summarize the latest knowledge about the importance of ADH enzymes in the physiology and metabolism of fungal cells, as well as their structure, regulation, evolutionary relationships, and biotechnological potential.

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Botrytis cinereaalcohol dehydrogenase mediates fungal development, environmental adaptation and pathogenicity

Cited by 7 publications

References 57 publications

Endophytic Bacterium Serratia plymuthica From Chinese Leek Suppressed Apple Ring Rot on Postharvest Apple Fruit

Endophytic Bacterium Serratia plymuthica From Chinese Leek Suppressed Apple Ring Rot on Postharvest Apple Fruit

Endophytic bacterium Pseudomonas protegens suppresses mycelial growth of Botryosphaeria dothidea and decreases its pathogenicity to postharvest fruits

Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential

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