Identificação do agente etiológico da Doença de Lyme-símile brasileira (Síndrome Baggio-Yoshinari)

Mantovani, Elenice

doi:10.11606/t.5.2010.tde-04112010-145154

Cited by 4 publications

(7 citation statements)

References 49 publications

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“…MANTOVANI 26 in her PhD thesis, presented to Faculdade de Medicina da Universidade de São Paulo, identified the etiological agent as spirochete belonging to B. burgdorferi sensu lato complex, executing a PCR assay, employing a conserved gene that synthesizes the flagellar hook (flgE) 30 (unpublished data). Other preliminary unpublished results also showed that ticks from genus Rhipicephalus and domestic animals like horses and bovines were infected by microorganisms and can participate in the epidemiological process of this emergent Brazilian tick borne disease.…”

Section: Introductionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to evaluate the epidemiological, clinical and laboratorial profile of patients with Baggio-Yoshinari Syndrome (BYS), who underwent internment at the Instituto de Infectologia Emilio Ribas in São Paulo, Brazil, during the period from July 1990 to July 2006. BYS is a new Brazilian tick-borne disease caused by Borrelia burgdorferi sensu lato microorganisms that resembles features of Lyme disease (LD), except for its epidemiological, clinical and laboratorial particularities. From 60 patients' records with positive serology to B. burgdorferi done by ELISA and Western-blotting methods, 19 cases were diagnosed as having BYS, according to criteria adopted at LIM-17 HCFMUSP, the Brazilian Reference Laboratory for the research of BYS. The other 41 remaining patients displayed miscellaneous infections or auto-immune processes. The beginning of symptoms in BYS group varied from one day to six years, from the onset of the disease. Four of 19 patients were included in acute disease stage, and 15 in latent. General unspecific symptoms were identified in almost all cases, with high frequencies of fever (78.9%) and lymphadenomegaly (36.8%). Six patients had skin lesions (31.5%); six arthralgia or arthritis (31.5%) and eight neurological symptoms (42%). Interestingly, two patients showed antibodies directed to B. burgdorferi exclusively in cerebrospinal fluid. Since BYS is a new emergent Brazilian zoonosis and its diagnosis is sometimes complex, all the new knowledge about BYS must be scattered to Brazilian Medical specialists, aiming to teach them how to diagnose this amazing tick-borne disease and to avoid its progression to chronic irreversible sequels.

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Section: Introductionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…However, in Brazil, infection due to B. coriaceae still has not been detected, and there has also not been any successful isolation of B. burgdorferi. Recently, Mantovani (2010) suggested that B. burgdorferi lato sensu was a microorganism of atypical morphology for which culturing in aerobic and anaerobic media (including BSK) was impossible, and that it was observed in Brazilian patients with a disease similar to Lyme borreliosis. This affirmation was based on amplification and sequencing of a fragment of the gene flgE, which is responsible for synthesis of the flagellar hook of B. burgdorferi, and this author had also identified this spirochete in ticks on horses and cattle in the states of Espírito Santo and Rio de Janeiro, with 99% homology.…”

Section: Discussionmentioning

confidence: 99%

Detection of anti-Borrelia burgdorferi antibodies in buffaloes (Bubalus bubalis) in the state of Pará, Brazil

Corrêa

Teixeira

Oliveira

et al. 2012

Rev. Bras. Parasitol. Vet.

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Detection of anti-Borrelia burgdorferi antibodies in buffaloes (Bubalus bubalis) in the state of Pará, Brazil AbstractThis study aimed to investigate the frequency of homologous antibodies of IgG class against Borrelia burgdorferi in buffaloes in the state of Pará, Brazil. Blood serum samples from 491 buffaloes were analyzed by means of the indirect ELISA test, using crude antigen produced from a cultivar of the North American strain G39/40 of B. burgdorferi. There were 412 positive samples (83.91%), and there was no statistically significant difference in the proportions of positive animals between the 81.69% (232/284) originating from Marajó Island and the 86.96% (180/207) from the continental area of the state of Pará. In all the municipalities studied, the frequency of positive findings of antibodies against B. burgdorferi among the animals ranged from 63.6% to 92.9%. The high numbers of seropositive animals can be explained by the frequent presence of the tick Rhipicephalus (Boophilus) microplus, and by the possible existence of spirochetes of the genus Borrelia infecting buffaloes in the region studied, although specific studies are needed to confirm this relationship. These factors suggest that a cross-reaction exists between the North American strain G39/40 of B. burgdorferi, which is used as an antigenic substrate, and the species of Borrelia spp. that possibly infects buffaloes in the state of Pará.Keywords: Buffaloes, Borrelia spp., epidemiology, serology. ResumoEste estudo teve como objetivo investigar a frequência de anticorpos homólogos da classe IgG contra Borrelia burgdorferi em búfalos do estado do Pará. Amostras de soro de 491 búfalos foram analisadas por meio do teste ELISA indireto, utilizando antígeno bruto produzido a partir do cultivo da cepa norte americana G39/40 de B. burgdorferi. Foram encontrados 412 soros positivos (83,91%), não havendo diferença estatística significativa entre os 81,69% (232/284) animais positivos provenientes da Ilha de Marajó e os 86,96% (180/207) da base continental do estado do Pará. Em todos os municípios estudados os animais apresentaram frequência de anticorpos contra B. burgdorferi, com positividade variando de 63,6% a 92,9%. O alto número de soropositivos pode ser explicado pela frequente presença do carrapato Rhipicephalus (Boophilus) microplus e pela possível existência de espiroquetas do gênero Borrelia infectando búfalo na região estudada, embora novos estudos sejam necessários para a confirmação desta relação. Estes fatos sugerem reação cruzada entre a cepa americana G39/40 de B. burgdorferi utilizada como substrato antigênico e a espécie de Borrelia spp. que possivelmente infecta bubalinos no estado do Pará.

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“…In 2008, Elenice Mantovani, for her PhD dissertation at the HCFMUSP [34], was invited to attempt to identify the etiological agent of BYS employing PCR procedures and try to understand the significance of spirochete-like structures present in patients with SBY. It is important to note that such structures are also present in normal individuals, although this finding is statistically less frequent in healthy people.…”

Section: Molecular Biology Researchesmentioning

confidence: 99%

“…In addition, Mantovani (2008) [34,39] carried out the same PCR test with flgE primer in 47 samples of ticks collected from risk areas in Espirito Santo State, 17 being Rhipicephalus microplus and 30 Rhipicephalus sanguineus. In addition to these ticks, she included DNA extracted from the blood of 27 buffalos and 26 horses, kindly provided by Prof Adivaldo H. Fonseca from the Universidade Federal Rural of Rio de Janeiro.…”

Section: Molecular Biology Researchesmentioning

confidence: 99%

“…The medical literature reported that spirochetes in unfavorable conditions, such as changes within the host, pH or temperature modifications and the introduction of antibiotics into the growth medium, can provide the origin of morphologically different structures resembling round and dense Chlamydia-like structures, cell wall-deficient Mycoplasma, such as in organisms, and non-motile spirochete-like filaments [50,51] (Figure 8). In 2010, Mantovani [34] also studied the possibility that spirochete-like structures observed in BYS patients could infect endothelial cell cultures in vitro. Initially, she seeded 1 mL of blood from the BYS patient in SP-4 medium.…”

Section: Microbiological Researchmentioning

confidence: 99%

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The Current State of Knowledge on Baggio–Yoshinari Syndrome (Brazilian Lyme Disease-like Illness): Chronological Presentation of Historical and Scientific Events Observed over the Last 30 Years

et al. 2022

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Baggio–Yoshinari Syndrome (BYS) is an emerging Brazilian tick-borne infectious disease that clinically mimics Lyme Disease (LD) present in the Northern Hemisphere. LD is caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex and transmitted by Ixodid ticks of complex Ixodes rticinus. On the contrary, BYS is transmitted by hard Ixodid ticks of the genera Amblyomma, Rhipicephalus and Dermacentor. In 1992, the first cases of BYS were described in patients that developed EM rash, flu-like symptoms and arthritis after tick bite episodes. Since these findings, research in BYS has been developing for more than 30 years and shows that its epidemiological, clinical and laboratorial features are different from LD. Borrelia burgdorferi was never isolated in Brazil. In addition, specific serologic tests have shown little positivity. Furthermore, peripheral blood analysis of patients using electron microscopy exhibited structures resembling spirochete-like microorganisms or the latent forms of spirochetes (L form or cell wall deficient bacteria). For these reasons, Brazilian zoonosis was defined as an exotic and emerging Brazilian infectious disease, transmitted by ticks not belonging to the Ixodes ricinus complex, caused by latent spirochetes belonging to the B. burgdorferi sensu lato complex with atypical morphology. The Brazilian ecosystem, combined with its ticks and reservoir biodiversity, possibly contributed to the origin of this new zoonosis, which emerged as a result of the passage of B. burgdorferi through exotic vectors and reservoirs.

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Identificação do agente etiológico da Doença de Lyme-símile brasileira (Síndrome Baggio-Yoshinari)

Cited by 4 publications

References 49 publications

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Detection of anti-Borrelia burgdorferi antibodies in buffaloes (Bubalus bubalis) in the state of Pará, Brazil

The Current State of Knowledge on Baggio–Yoshinari Syndrome (Brazilian Lyme Disease-like Illness): Chronological Presentation of Historical and Scientific Events Observed over the Last 30 Years

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