Identification of Candida lusitaniae as an opportunistic yeast in humans

Holzschu, Donald L.; Presley, Heather L.; Miranda, Mary; Phaff, H. J.

doi:10.1128/jcm.10.2.202-205.1979

Cited by 74 publications

(28 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both ofthese cycle lengths are larger than the maximum difference in G + C contents observed for varieties of one species. Price et al (1978) and Holzschu et al (1979) gave this value from 1 to 1.5%, based upon DNA-DNA hybridization studies. This is further evidence for the existence of a nongradual evolution of G + C values, for if the divergence in G + C values had been gradual, then only those intermediate varieties which did not "fit" the periodic function would have been lost, which seems improbable.…”

Section: Resultsmentioning

confidence: 95%

QUANTUM AND CONTINUOUS EVOLUTION OF DNA BASE COMPOSITION IN THE YEAST GENUS PICHIA

1986

View full text Add to dashboard Cite

This paper investigates the noncontinuous nature and evolution of the base composition of nuclear DNA (expressed as mol% guanine + cytosine) in species of the yeast genus Pichia (sensu Kurtzman, 1984b). The pattern of change in the G + C contents in species of this genus, which range from about 27 to 52 mol%, was evaluated. When specifically those species of Pichia were analyzed that have evolved in necroses of cactus species and associated Drosophila, a periodic change in the G + C contents of approximately 3.0-3.2 mol% was detected by a "bootstrapping" method, Fourier analysis, and a nonlinear trigonometric model. Pichia species occurring in exudates of broad-leaved deciduous trees or associated Drosophila and substrates such as soil and water ("other") showed a periodicity of 2.5-2.6 mol%, whereas species associated with conifers and associated bark beetles showed no significant periodicity. Periodicity in the most recent association (cactus and resident Drosophila) as compared to the lack of periodicity in the oldest association (conifer-beetle) may indicate mixed evolutionary processes. Low mol% G + C values appear more frequently in the relatively recent cactus and Drosophila-associated yeast species. In addition, low mol% G + C species do not display the ancestral bud-meiosis mode of sexual reproduction which occurs frequently in medium to high mol% G + C yeasts. It was found that the mol% G + C content of the Drosophila- and cactus-associated Pichia species is positively correlated with the number of compounds fermented or respired by these yeast species. Possible reasons for the periodic changes in mol% G + C content accompanying speciation include aneuploidy, allopolyploidy, the presence of nuclear plasmids, and regular differences in moderately repetitive portions of DNA. Since significant DNA complementarity is virtually limited to species within a relatively narrow G + C group, this suggests that there are at least two processes which alter the G + C content between species, one saltational and one continuous.

show abstract

Section: Resultsmentioning

confidence: 95%

QUANTUM AND CONTINUOUS EVOLUTION OF DNA BASE COMPOSITION IN THE YEAST GENUS PICHIA

1986

View full text Add to dashboard Cite

show abstract

“…Лимфаденопатия при грибковой инфекции не отличается от таковой при бактериальной или вирусной при физикальном исследовании [4]. Возбудитель C. lusitaniae был впервые выделен в самостоятельный вид в 1979 г. от пациента с острым миелобластным лейкозом [5] и представляет особый интерес ввиду резистентности к амфотерицину В [6]. Несмотря на редкую встречаемость [7], данный микроорганизм способен вызывать фунгемии…”

Section: Discussionunclassified

Generalized granulomatous inflammation caused by <i>Candida lusitaniae</i> in a patient with myelofibrosis

2019

View full text Add to dashboard Cite

В настоящей статье описывается клинический случай, демонстрирующий сложности прижизненной и посмертной диагностики у пациента с первичным миелофиброзом, осложненным генерализованной грибковой инфекцией, вызванной редким возбудителем Candida lusitaniae. Ведение таких пациентов в непрофильном стационаре при отсутствии результатов трепанобиопсии костного мозга и многообразие клинических ситуаций, при которых могут определяться такие проявления, как нейтрофильный лейкоцитоз со сдвигом влево без значительного уменьшения количества эритроцитов и тромбоцитов совместно с генерализованной лимфаденопатией и визуализацией вторичных очагов во внутренних органах, вызывает особое затруднение, становясь причиной неверной тактики лечения. Наслоение нескольких патологических процессов друг на друга (гранулематозное воспаление, очаги экстрамедуллярного кроветворения и обширные некротические изменения) затрудняет даже посмертную верификацию диагноза.

show abstract

“…En las últimas décadas las infecciones por levaduras han alcanzado una gran importancia no sólo por su aelevada frecuencia en pacientes con compromiso inmune o enfermos sometidos a técnicas diagnósticas y terapéuticas invasivas, sino además, al surgimiento de formas clínicas diseminadas y a su alta morbilidad y mortalidad. Paralelamente se ha notado un aumento en la aparición de nuevas especies patógenas, cuyo diagnóstico y tratamiento muchas veces resulta dificultoso (2,6,8,10,11,19,20).…”

Section: Discusionunclassified

“…Numerosos informes han documentado la aparición de especies distintas a C. albicans como C. glabrata C. krusei, C. guilliermondii, C. dubliniensis, y C. lusitaniae entre otras, responsables de graves y aun fatales infecciones en el hombre. Este hecho puede estar relacionado con el uso creciente de antifúngicos, tanto en profilaxis como en tratamientos empíricos (2,6,9,10,11,15,17,19,20,32).…”

Section: Introduccionunclassified

“…obtusa y fue aislada por primera vez en 1959 por Van Uden y do Carmo-Sousa como microorganismo de la microbiota intestinal de animales de sangre caliente (14 ) y su forma teleomorfa se denomina Clavispora lusitaniae Rodríguez de Miranda (Ascomycota, Hemiascomycetes, Saccharomycetales: Metschnikowiacae). Después, en 1979, Papagianis (21) & Holschu (11), describieron los primeros casos de infección humana oportunista a la vez que demostraron su capacidad para desarrollar resistencia a la anfotericina B en el curso del tratamiento. Posteriormente otros autores publicaron los primeros casos de aislamiento de la levadura en sangre y casos de infección nosocomial, algunos por mecanismo de transmisión exógeno, y en otras por infección cruzada (2,5,9,31,32,33).…”

Section: Introduccionunclassified

See 1 more Smart Citation

Candida lusitaniae EN UN PACIENTE PEDIATRICO INMUNOCOMPROMETIDO: EXITO TERAPEUTICO DEL VORICONAZOL

Runco

Salim

2005

Bol. Micol.

View full text Add to dashboard Cite

Palabras clave: Candida lusitaniae, paciente pediátrico, Voriconazol RESUMENCandida lusitaniae es reconocida como un patógeno emergente, ocasionalmente responsable de graves infecciones nosocomiales en pacientes con compromiso inmune. Esta levadura plantea dos desafíos importantes; la posibilidad de una identificación errónea de la especie y su resistencia primaria o adquirida a la Anfotericina B. El presente trabajo informa el aislamiento en cultivos puros de C.lusitaniae desde el líquido cefalorraquídeo de un paciente pediátrico inmunocomprometido, de 5 meses de edad, hospitalizado por hidrocefalia posthemorrágia neonatal valvulada. El paciente fue tratado inicialmente con Anfotericina B, substituida posteriormente por Voriconazol. Se destaca el éxito terapéutico de éste último en la dosis usada en este caso. Luego de un prolongado período de hospitalización el paciente fue dado de alta. Consideramos que para entender la importancia clínica de esta levadura, es necesario investigaciones más completas tanto de su epidemiología como de los mecanismos de resistencia a los antifúngicos y de su frecuencia, tanto in vivo como in vitro, condiciones útiles para entender algunas de las razones de la emergencia de C. lusitaniae en clínica. ABSTRACTCandida lusitaniae is known to be an emerging pathogenous which is occasionally responsible for serious nosocomial infections in immunocompromised patients. This yeast involves two significant challenges: the possibility of a wrong identification of the species and its primary or acquired resistance to Anfotericina B. The present paper reports the isolation of C.lusitaniae in pure cultures taken from a 5-month aged immunocompromised pediatric patient who had been diagnosed with a neonatal post hemorrhagic valvular hydrocephalus. The patient was firstly treated with Anfotericena B and later on with Voriconazole. The therapeutic success of the latter medication as used in this case is pointed out. After being a long time in the hospital, the patient was sent home. In order to understand the clinical significance of this yeast, we think it is necessary to carry out further research work both in its epidemiology and in its antifungal drug resistance mechanisms together with its frequency in situ and in vitro,being the above requirements useful to recognize the reasons for. C lusitaniae emergence in the clinic.

show abstract

Identification of Candida lusitaniae as an opportunistic yeast in humans

Cited by 74 publications

References 12 publications

QUANTUM AND CONTINUOUS EVOLUTION OF DNA BASE COMPOSITION IN THE YEAST GENUS PICHIA

QUANTUM AND CONTINUOUS EVOLUTION OF DNA BASE COMPOSITION IN THE YEAST GENUS PICHIA

Generalized granulomatous inflammation caused by <i>Candida lusitaniae</i> in a patient with myelofibrosis

Candida lusitaniae EN UN PACIENTE PEDIATRICO INMUNOCOMPROMETIDO: EXITO TERAPEUTICO DEL VORICONAZOL

Contact Info

Product

Resources

About