IgG-Class Insulin Autoantibodies in Autoimmune Thyroid Disease

Abstract

We studied the incidence of insulin autoantibodies (IAA) in 97 patients with autoimmune thyroid disease with an enzyme-linked immunosorbent assay. The sera were also tested for islet cell antibodies (ICA) and thyrotropin receptor antibodies (TRAb). IAA as assessed by a standard deviation score were present in 7 patients (7.2%). None of the patients were seropositive for ICA. Data from this random sampling and a retrospective study of 12 patients on antithyroid drug treatment indicated that the presence of IAA was not associated with TRAb.

Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody

“…Many studies have showed the prevalence rate of thyroid autoantibodies ranging from 3.7–35% in T1DM patients, some of which suggested the associations between thyroid autoantibodies and islet autoantibodies ( 10 , 11 , 12 , 13 , 14 ). However, little work has been done on the anti-islet autoimmune status in non-diabetic patients with AITD ( 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ). As summarized in Supplementary Table 1 (see section on supplementary materials given at the end of this article), the prevalence rates of glutamic acid decarboxylase autoantibodies (GADA), islet cell autoantibodies (ICA), insulinoma-associated antigen 2 autoantibodies (IA-2A) and insulin autoantibodies (IAA) in patients with AITD were either slightly or significantly higher than those in healthy controls (HC), indicating the distinct value of studying islet immune status in AITD.…”