The gender peculiarities of metabolic status were studied in patients with acute coronary syndrome who underwent outpatient rehabilitation in the day hospital. It was found that in the overwhelming majority of patients of both sexes there was not only an increase in body mass index values relative to normal values, but also the waist circumference as a sign of abdominal fat tissue deposition. In the group of women the values of these indices were higher than in men. They were much more frequently diagnosed with 1st and 3rd degree obesity as compared to men with higher frequency and severity of abdominal obesity. The study of blood lipid and carbohydrate spectra revealed initially more significant fat metabolism disorders in male patients, but in comparison with female patients after rehabilitation measures more pronounced positive dynamics of blood biochemical indices was observed: decrease of values of low density lipoproteins, atherogenicity index and triglycerides. In carrying out stress testing, men, compared with women, both before and after rehabilitation showed a higher tolerance for physical activity and aerobic reserves of the cardiorespiratory system, which, among other indicators, indicates a higher efficiency of their rehabilitation course.