Immune Response and Adult Mortality Associated with the B Locus in Chickens

Nordskog, A. W.; Pevzner, I. Y.; Trowbridge, Carolyn L.; Benedict, Albert A.

doi:10.1007/978-1-4613-4169-7_23

Cited by 14 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MHC is involved intimately in the immune response of animals to foreign antigens (McDevitt and Chinitz, 1969;Benacerraf and McDevitt, 1972;Biozzi et al, 1979;Klein, 1979 (Lilly, 1968), in man (Braun, 1979;Svejgaard et al, 1981) and in the chicken (Nordskog et al, 1977;Pevzner et al, 1981;Briles et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Breed and Swine Lymphocyte Antigen Haplotype Differences in Agglutination Titers Following Vaccination with B. Bronchiseptica2

Rothschild

Chen

Christian

et al. 1984

Journal of Animal Science

View full text Add to dashboard Cite

Genetic differences in immune response to B. bronchiseptica after vaccination with a commercial B. bronchiseptica bacterin were investigated in 1,069 8-wk-old pigs. These pigs were from 65 litters born in the spring and 66 litters born in the fall of 1982 and were purebreds from the Chester White (n = 128), Duroc (n = 281), Hampshire (n = 143), Landrace (n = 309) and Yorkshire (n = 208) breeds. Each litter was raised separately. Individual pigs were vaccinated im at 4 and 6 wk of age with 2 ml of B. bronchiseptica bacterin. At 8 wk of age, 8 ml of blood were collected from each animal and serum prepared to determine agglutinating antibody titers against B. bronchiseptica bacterin by a bacterial agglutination method. In addition, lymphocytes were separated from 1 ml of heparinized blood and used to determine Swine Lymphocyte Antigen (SLA) haplotypes by using cytotoxic antibodies against the SLA complex. Antisera for 3 SLA haplotypes were made available by the National Institutes of Health. Results indicated that breed of pig (P<.01) and dam of pig (P<.01) affected the immune response of the pig after B. bronchiseptica vaccination. Higher immune response was also associated (P<.05) with one of the SLA haplotypes tested. Heritability estimates for immune response following vaccination were .10 ± .12 (half-sib) and .42 ± .19 (full-sib). Results suggest that the relationship of the SLA complex to immune response in the pig and nonadditive genetic and maternal effects on immune response should be further investigated. SummaryGenetic differences in immune response to B. bronchiseptica after vaccination with a commercial B. bronchiseptica bacterin were investigated in 1,069 8-wk-old pigs. These pigs were from 65 litters born in the spring and 66 litters born in the fall of 1982 and were purebreds from the Chester White (n = 128), Duroc (n = 281), Hampshire (n = 143), Landrace (n = 309) and Yorkshire (n = 208) breeds. Each litter was raised separately. Individual pigs were vaccinated im at 4 and 6 wk of age with 2 ml of B. bronchiseptica bacterin. At 8 wk of age, 8 ml of blood were collected from each animal and serum prepared to determine agglutinating antibody titers against B. bronchiseptica bacterin by a bacterial agglutination method. In addition, lymphocytes were separated from 1 ml of heparinized blood and used to determine Swine Lymphocyte Antigen (SLA) haplotypes by using cytotoxic antibodies against the SLA complex. Antisera for 3 SLA haplotypes were made available by the National Institutes of Health. Results indicated that breed of pig (P<.01) and dam of pig (P<.O1) affected the immune response of the pig after B. bronchb septica vaccination. Higher immune response was also associated (P<.05) with one of the SLA haplotypes tested. Heritability estimates

show abstract

Section: Introductionmentioning

confidence: 99%

Breed and Swine Lymphocyte Antigen Haplotype Differences in Agglutination Titers Following Vaccination with B. Bronchiseptica2

Rothschild

Chen

Christian

et al. 1984

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…The SI population of White Leghorns (Nordskog et al, 1973), segregates for B 1 , B 2 , and B 19 alleles of the B complex. From these, all homozygous combinations are reproducible in each hatch.…”

Section: Methodsmentioning

confidence: 99%

Immune Response and Disease Resistance in Chickens

1981

View full text Add to dashboard Cite

A selection experiment for high and low anti-Salmonella pullorum antibody titer was carried out over four generations within the B1B1 blood group genotype in chickens. The study was aimed primarily at identifying different response patterns controlled by immune response genes linked to the B system, the major histocompatibility complex of the chicken. Maximal divergence was obtained in the third generation of selection when agglutination titers of 1/320 and 1/80 in B1B1 high and low responders, respectively, were reached. Immune response of S. pullorum was deduced to be controlled by polygenes. The B1B1 population, selected for high immune response to S. pullorum antigen, consistently had greater total mortality as well as greater susceptibility to challenge with Marek's disease virus compared with B1B1 population selected for low response. This, however, is believed to be a consequence of random drift of genes for disease resistance in the relatively small populations and not a direct consequence of selection for high or low S. pullorum titer.

show abstract

“…The possibility of utilising a simpler strategy, that of enhancing the immune response generally has led to much work on the general immune response Miggiano et al, 1976;Okabayishi and Okada, 1977;Koch and Simonsen, 1977;Nordskog et al, 1977;Krieg et al, 1978;Abplanalp, 1979;Zijpp and Leenstra, 1980;Yanagimoto and Okada, 1980;Hâla et dl., 1981;Zijpp, 1983;Zijpp et al, 1983;Goidl and Theis, 1985;Ubosi et dl., 1985;Bacon et al, 1986) but to date little (Gross et al, 1980) or no correlation (Soller et dl., 1981) has been found between responsiveness to different diseases.…”

Section: Genes For Insertionmentioning

confidence: 99%