2018
DOI: 10.3390/s18061932
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Immuno Nanosensor for the Ultrasensitive Naked Eye Detection of Tuberculosis

Abstract: In the present study, a beneficial approach for the ultrasensitive and affordable naked eye detection and diagnosis of tuberculosis (TB) by utilizing plasmonic enzyme-linked immunosorbent assay (ELISA) via antibody-antigen interaction was studied. Here, the biocatalytic cycle of the intracellular enzymes links to the formation and successive growth of the gold nanoparticles (GNPs) for ultrasensitive detection. The formation of different colored solutions by the plasmonic nanoparticles in the presence of enzyme… Show more

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Cited by 28 publications
(15 citation statements)
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“…Plasmonic ELISAs have been used to investigate the diagnosis of different diseases, including cancer, HIV and fungal and bacterial infections, using a capture ELISA protocol and have shown several advantages in relation to sensitivity. However, only one report has described a bacterial diagnosis using an indirect ELISA protocol .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Plasmonic ELISAs have been used to investigate the diagnosis of different diseases, including cancer, HIV and fungal and bacterial infections, using a capture ELISA protocol and have shown several advantages in relation to sensitivity. However, only one report has described a bacterial diagnosis using an indirect ELISA protocol .…”
Section: Discussionmentioning
confidence: 99%
“…Although pELISA has been used to investigate different diseases, including cancer, HIV and fungal and bacterial infections, its use in diagnosing CanL has not been investigated. Recently, we developed and successfully tested an indirect pELISA on canine sera positive and negative for Leishmania spp.…”
Section: Introductionmentioning
confidence: 99%
“…The pathological test of the Gold Nanoparticles (AuNP) based plasmonic ELISA for TB-antigen specific antibody detection, referred to as the TB-test, is one of the case studies for assay type detection in this paper. The description of the sample preparation for the TB-test is provided in (Abuhassan et al, 2017;Tania et al, 2017;Bakhori et al, 2018). However, the development of biosensor is not the focus of this work.…”
Section: Dataset Preparationmentioning
confidence: 99%
“…One is the Gold Nanoparticles (AuNP) based plasmonic ELISA for TB-antigen specific antibody detection, referred to as the TB-test in this paper. The description of the sample preparation for the TB-test is provided in [9], [41], [42]. However, development of the biosensor is not the focus of this work.…”
Section: A Data Collectionmentioning
confidence: 99%