Immunobiological specificity of antibodies against glutamate and γ-aminobutyric acid

Abstract

Experiments on C57Bl/6 mice showed that chronic epileptization of the brain (pharmacological pentylenetetrazole kindling) is accompanied by induction of autoantibodies against glutamate and GABA. Immunohistochemical similarity of antibodies against glutamate and GABA was demonstrated. Study on the model of pentylenetetrazole-induced acute generalized epileptiform activity showed high immunobiological specificity of intraperitoneally injected antibodies against GABA and glutamate: antiepileptic effect of antiglutamate antibodies and proepileptic effect of antibodies against GABA.

Antiamnestic Effects of Antibodies to Glutamate in Experimental Alzheimer’s Disease

“…The possibility of Glu-Ab production was previously demonstrated [1,4,5]. We recently demonstrated the production of Glu-Ab in AD [2,3] and revealed peculiarities of Glu-Ab production in patients with various forms of AD.…”

Stress-Protective and Stress-Potentiating Effects of Antibodies to Glutamate and γ-Aminobutyric Acid after Intranasal Administration in C57Bl/6 Mice

“…Glutamate (Glu) and GABA play a key role in central integration of HPA stress responses [11,12]. We previously showed the effects of antibodies (Ab) to Glu and GABA during active immunization with Glu-BSA and GABA-BSA conjugates on the development of convulsive reaction to pentilentetrazole, neurogenic pain syndrome, and combined water immersion stress [2,4,6]. A possible mechanism underlying the effect of Ab to neurotransmitters during active immunization is a direct infl uence on the brain Glu-and GABA-ergic systems.…”

Effect of Antibodies to Glutamate and GABA on the Stress Response in C57Bl/6 Mice

“…Previous studies revealed that antibodies to dopamine and serotonin play a role in immune modulation of brain functions that are related to the behavior and emotional state [2,6]. Antibodies to GLU and GABA had a modulatory effect on the symptoms of experimental epileptogenesis and central pain syndrome [1,3]. However, little is known about the influence of antibodies to GLU and GABA on the behavioral stress reaction in animals.…”