Immunoglobulin E Antibodies to Papaya Proteinases and Their Relevance to Chemonucleolysis

Dando, Pamela M.; Sharp, Simon L.; Buttle, David J.; Barrett, Alan J.

doi:10.1097/00007632-199505000-00001

Cited by 12 publications

(9 citation statements)

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“…The fragmented proteoglycan molecules diffuse from the disk causing a reduction in hydrostatic pressure on the nerve root and thus an easing of pain and disability. The most common adverse reactions associated with chemonucleolysis are due to an allergic response [74]. Because of their allergenicity preparations containing the papaya endopeptidases, particularly powders such as dried papaya latex, should be handled with care [8].…”

Section: Morrenain O IImentioning

confidence: 99%

Occurrence and Properties of Proteases in Plant Latices

2008

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Section: Morrenain O IImentioning

confidence: 99%

Occurrence and Properties of Proteases in Plant Latices

2008

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“…CPs are renowned for their allergenic properties [ 99 ]. For example, Der p I from the house dust mite, which is responsible for many cases of asthma and various types of allergies, is related to those from fruits such as papaya [ 100 ].…”

Section: Side Effects and Pathologymentioning

confidence: 99%

Developing novel anthelmintics from plant cysteine proteinases

et al. 2008

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Intestinal helminth infections of livestock and humans are predominantly controlled by treatment with three classes of synthetic drugs, but some livestock nematodes have now developed resistance to all three classes and there are signs that human hookworms are becoming less responsive to the two classes (benzimidazoles and the nicotinic acetylcholine agonists) that are licensed for treatment of humans. New anthelmintics are urgently needed, and whilst development of new synthetic drugs is ongoing, it is slow and there are no signs yet that novel compounds operating through different modes of action, will be available on the market in the current decade. The development of naturally-occurring compounds as medicines for human use and for treatment of animals is fraught with problems. In this paper we review the current status of cysteine proteinases from fruits and protective plant latices as novel anthelmintics, we consider some of the problems inherent in taking laboratory findings and those derived from folk-medicine to the market and we suggest that there is a wealth of new compounds still to be discovered that could be harvested to benefit humans and livestock.

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“…Phospholipases, proteases or both are associated with insect venoms, parasite secretions, HDM and cockroach emanations, fungal spores, grain dust, and plant pollens [45]. The major allergen from domestic cats, Fef d I, co-isolates with a kallikrein protease [46], and about 1 % of patients treated by chemonucleolysis with papaya proteinases developed allergic responses [47]. The presence of hydrolytic enzymes in allergenic material suggested that these might initially stimulate allergic responses by an IgEindependent mechanism.…”

Section: Mediator Release In Response To Enzymes Associated With Commmentioning

confidence: 99%

Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen‐specific IgE

et al. 1996

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A number of structurally diverse antigens preferentially stimulate the synthesis of IgE antibodies, but no unifying principle has been proposed that explains the nature of isotype selection. In the present study, we show that common allergens present in bee venom, house dust mite emanations and parasite proteins induce mast cell and basophil degranulation and stimulate interleukin-4 synthesis, and secretion in the absence of antigen-specific IgE. These data point to a linkage between the initial activation of cells of the innate immune system and subsequent adaptive immune responses. They suggest that IgE-independent mast cell and basophil degranulation is predictive of potential allergenicity and can be evaluated by means of a cellular assay. Our study indicates that non-immunological degranulation by prototypic allergens, such as bee venom phospholipase A2 or proteases associated with house dust mite emanations, is critically dependent on enzymatic activity. These findings have potentially important implications for vaccine design in allergic and parasitic disease.

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Immunoglobulin E Antibodies to Papaya Proteinases and Their Relevance to Chemonucleolysis

Cited by 12 publications

References 0 publications

Occurrence and Properties of Proteases in Plant Latices

Occurrence and Properties of Proteases in Plant Latices

Developing novel anthelmintics from plant cysteine proteinases

Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen‐specific IgE

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