Immunoregulatory actions of polysaccharides from Chinese herbal medicine

Jiang, Minghua; Zhu, Liang; Jiang, Jian-Guo

doi:10.1517/14728222.2010.531010

Cited by 162 publications

(85 citation statements)

References 136 publications

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“…RTP1 can significantly increase the level of serum hemolysin and the activity of NK cells from mice spleen, suggesting it can antagonize the radiation-induced deficiency in humoral and cellular immunity, in line withthe literature (Vincent et al, 2000;Xie et al, 2006;Jiang et al, 2010), but it is still to be further studied that whether the immune enhancement is due to the presentation of MHC II molecules and direct or indirect identify of αβ-TCR, which leads to the activation of the adaptive cellular immune response or the generation of specific antibodies through the effective activation of B lymphocytes.…”

Section: Discussionsupporting

confidence: 82%

“…Now, the lentinan and polysaccharides of ganoderma lucidum, bidentata, polyporus, huangqi, yunzhi and etc are commonly used in clinical (Tzianabos, 2000;He et al, 2012). The immunologic enhancement of Chinese herbal medicine is realized via the following pathway: (1) activation of the reticuloendothelial and addiment system; (2) activation of macrophages, T and B lymphocytes, NK cells; (3) regulating the activity of immune promoters and inhibitors to enhance immunity of erythrocyte; (4) regulating the neuroendocrine network to play an immunomodulatory role; (5) induced various cytokines (CKs), including interferon (IFN-a, β, γ), interleukin (IL), tumor necrosis factor (TNF-a, β), colony-stimulating factor (CSF) and dozens of species from four series so far (Vincent et al, 2000;Lin, 2005;Xie et al, 2006;Jane et al, 2010;Jiang et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Liu

Guo²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice. Methods: Kunming mice were randomly divided into five groups: normal group (NC), irradiation control group (IC), RTP1 low dose (200 mg/kg), middle dose (400 mg/kg) and high dose (800 mg/kg) groups. RTP1 was adminstered by the gastric route for 14 d, mice in the NC and IC groups being given by 0.9% sodium chloride solution in the same way. The mice in all groups except NC group were irradiated with 2.0 Gy 60 Co γ-ray on the fourteenth day. Immune indives of non-specific immune function, cellular immunity and humoral immunity were assessed at the 24th hour after radiation. Results: Compared with the IC group, the spleen index, thymus index, rate of carbon clearance, phagocytic function of macrophages, lymphocyte proliferation, hemolysin value of blood serum and NK activity were increased markedly (P < 0.05 or P < 0.05). Conclusion: RTP1 has an obvious protective effects on damage in γ-ray radiated mice.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Liu

Guo²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…이러한 천연물유래 다당체들은 대식세포, 림프구, natural killer (NK)세포 등 면역세 포의 활성화 및 면역관련 cytokine들의 분비를 유도함으로써 체 내 면역능을 증진시킨다고 알려져 있어 (12), 면역반응조절제 (immunopotentiator) 후보물질들로 천연물 유래 다당체를 이용한 많은 연구가 진행되고 있다 (13)(14)(15)(16). 이전 연구에서 본 연구팀은 감잎을 대상으로 열수추출 및 효 소처리를 행하고, 이로부터 다당류를 분리하여 성분 특성을 밝혔 으며, 각종 면역자극 활성을 평가하여 감잎 유래 다당체들이 다 양한 면역관련 지표들을 증가시키는 것을 확인하였다 (17 (Fig.…”

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Immunomodulatory Effects of Polysaccharides Derived from Persimmon Leaves on Cyclophosphamide-induced Immunosuppressed Mice

Cho¹,

Rhee²,

Kim³

et al. 2013

Korean Journal of Food Science and Technology

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We prepared 2 different crude polysaccharides from persimmon leaves, by hot water (PLW-0) and pectinase digestion (PLE-0), respectively. PLW-0 and PLE-0 showed similar sugar compositions and contained 11 different sugars, including rarely observed sugars such as 2-methyl-fucose, 2-methyl-xylose, apiose, and aceric acid. However, the uronic acid content of PLE-0 was lower than that of PLW-0, because of pectinase treatment. In normal mice, administration of PLW-0 and PLE-0 increased the spleen index and splenocyte proliferation. The effect of PLE-0 on the spleen index and splenocyte proliferation was greater than that of PLW-0. We subsequently assessed the immunomodulatory activities of PLW-0 and PLE-0 on cyclophosphamide (CY)-induced immunosuppressed mice. We revealed that mice treated with PLW-0 or PLE-0 showed increased splenocyte proliferation, NK cell activity, and white blood cell numbers. Taken together, our results indicate that PLW-0 and PLE-0 can enhance immune function in normal mice and modulate CY-induced immune suppression.

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“…Polysaccharides regulate host immune system by activating immune-related cell such as lymphocytes, macrophages, and NK cells (Jiang et al, 2010). Activating one of immune components will result in the activation of other immune components including B-lymphocytes in spleen.…”

Section: Resultsmentioning

confidence: 99%

Okra Polysaccharides Improves Spleen Weight and B-Lymphocytes Proliferation in Mice Infected by Staphylococcus aureus

et al. 2017

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Okra (Abelmoschus esculentus) is reported to have various biological functions such as antioxidant, anticancer and anti-inflammation. However, only few studies have been reported immunomodulatory activities of okra to prevent disease caused by bacteria infection. In this study, the immunomodulatory activities of polysaccharides from okra pods were investigated further through the spleen weight and B-lymphocytes proliferation in mice infected by Staphylococcus aureus. Okra polysaccharides were obtained by water extraction and ethanol precipitation. Okra polysaccharides with doses of 25, 50, 75, and 100 mg/kg BW were orally administrated to mice with or without Staphylococcus aureus infection. Spleen weight was evaluated in both treatment group and control group. B-lymphocytes proliferation was evaluated by MTT assay using LPS induction. Results showed that okra polysaccharide at the doses of 50, 75, and 100 mg/kg increased spleen weight (p < 0.05) significantly. While at the dose of 75 and 100 mg/kg, it increased the B-lymphocytes proliferation (p < 0.05) significantly. There is positive correlation between the spleen weight and B-lymphocytes proliferation by 73.3%. These result reveal that okra polysaccharide could improve the immune response and be utilized as a novel candidate of neutraceutical.

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Immunoregulatory actions of polysaccharides from Chinese herbal medicine

Cited by 162 publications

References 136 publications

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Immunomodulatory Effects of Polysaccharides Derived from Persimmon Leaves on Cyclophosphamide-induced Immunosuppressed Mice

Okra Polysaccharides Improves Spleen Weight and B-Lymphocytes Proliferation in Mice Infected by Staphylococcus aureus

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