Impact of Human Cytomegalovirus Infection associated with the expressed protein of mutated <i>BRCA1</i> gene in breast tissues from a group of Iraqi Female Patients with Breast Carcinoma

Ali, Saad Hasan Mohammed; AL-Mahbobi, Taghreed F.; Al-Bayaa, Yasmeen J.; Al-Alwany, Shakir H. Mohammed

doi:10.5958/0974-360x.2018.00280.9

Rese. Jour. of Pharm. and Technol.

2018

DOI: 10.5958/0974-360x.2018.00280.9

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Impact of Human Cytomegalovirus Infection associated with the expressed protein of mutated BRCA1 gene in breast tissues from a group of Iraqi Female Patients with Breast Carcinoma

Saad Hasan Mohammed Ali¹,

Taghreed F. AL-Mahbobi²,

Yasmeen J. Al-Bayaa³

et al.

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Cited by 3 publications

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“…The most common cause of infection is cytomegalovirus (CMV) infection 11 with symptoms of jaundice (62%), petechiae (58%), and hepatosplenomegaly (50%) 12 . Diagnosis of CMV infection in infants is carried out by isolating the virus from urine with culture techniques, blood serology by checking the detection of anti-CMV IgM and IgM, detection of CMV antigen by antigenemia assay on blood samples, detecting CMV DNA using polymerase chain reaction (PCR) techniques 13 and in situ hybridization in tissues 14 . Viral culture is the gold standard for the diagnosis of CMV.…”

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confidence: 99%

Detection of Cytomegalovirus in Urine Specimen of Cholestatic Infants by Polymerase Chain Reaction

Mastutik

Kurniasari

Rahniayu

et al. 2022

RJPT

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Cholestatic infants are associated with congenital abnormalities or viral infections, such as cytomegalovirus (CMV) infection. CMV can be detected by polymerase chain reaction (PCR) in body fluids, including urine which can be obtained easily and is non-invasive. The objective was to detect CMV in urine specimens of cholestasis infants and to analyze its correlation with serological status. This was a descriptive observational study with the cross-sectional approach, used urine from 39 cholestatic infants who meet the inclusion and exclusion criteria and have been approved by Ethics Committee. The nested-PCR was performed from extracted urine and unextracted direct urine. Serological data of immunoglobulin (Ig) M and IgG data were collected. Data were analyzed by Chi-square. Detection of CMV from extracted urine by PCR showed positive in 87.2% patients and from unextracted urine was positive in 48.7% patients. Serological status showed that IgM was positive in 41.0% patients and IgG was positive in 89.7% patients. The acute infection (IgM+ IgG+) was found in 41.0% patients, past infection (IgM-IgG+) was 48.7% patients, and not infected (IgM-IgG-) was in 10.3% patients. The acute infection (IgM+ IgG+), past infection (IgM-IgG+) and not infected (IgM-IgG-) was found in 41.0%, 48.7%, and 10.3% patients, respectively. The correlation between PCR CMV from extracted urine with serological CMV was moderate, while the unextracted urine was low. It indicates that to detect the infection of CMV, PCR technique is more accurate than serological testing, and the extracted urine is more appropriate specimen as PCR template than direct urine.

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mentioning

confidence: 99%

Detection of Cytomegalovirus in Urine Specimen of Cholestatic Infants by Polymerase Chain Reaction

Mastutik

Kurniasari

Rahniayu

et al. 2022

RJPT

View full text Add to dashboard Cite

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Prevalence of Human Cytomegalovirus in Breast Cancer: A Systematic Review

Nakhaie

Charostad

Ghaderi-Zefrehi

et al. 2021

Asian Pac J Cancer Biol

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Background: Breast cancer is the most common malignancy among women around the world, with several risk factors contributing to its progression. The role of infectious agents such as viruses in the progression of this cancer is relatively well-known, as a result of various studies in different geographical regions that reported the prevalence of cytomegalovirus in breast cancer. Objective: In this systematic review, we tried to examine the prevalence of cytomegalovirus in breast cancer. Materials and Methods: We conducted a comprehensive search of three databases: PubMed, Scopus, and Google Scolar up to January 21, 2021. Results: Out of 584 articles, 29 articles including 3158 samples were finally reviewed, of which 16 articles used PCR methods, 8 articles used serology method and 13 articles used other methods such as immunohistochemistry and in situ hybridization. The prevalence of the virus was higher in Asian and African countries such as Iraq and Egypt than other European and South American countries. Among these, the highest prevalence of the virus in different samples of patients with breast cancer was related to Iraq. Conclusion: The results of our study showed the higher prevalence of the virus in patients with breast cancer rather than normal subjects and reveal the role of the virus in the development of breast cancer.

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BRCA1, BCL2, and the RB Tumor Suppressor have abnormal expressions in lung cancer

Jassim

Naji

Mahmood

2022

RJPT

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The retinoblastoma (RB) gene encodes the retinoblastoma pocket protein, which controls the cell cycle by binding to unphosphorylated E2F transcription factors and inhibiting their activation. The function of BRCA1 and the anti-apoptotic protein Bcl-2 in lung cancer, however, is still debated. Objective:The purpose of this research is to look at the relationship between the cell-cycle proteins BRCA1, BCL2, and RB and lung cancer etiology and progression. Experimental Design: Cases from major hospitals and many private histopathological laboratories between 2018 and 2021 were reviewed for immunohistochemical expression of BRCA1, BCL2, and RB. A total of 60 people (20 healthy people as a control group and 40 patients with lung carcinoma) were reviewed and analyzed for immunohistochemical expression of these genes. Results: In (90.0%) of cases, RB-IHC was overexpressed, according to the data. The BRCA1 overexpression was seen in (95.0 %). Though BCL2 was overexpressed in (92.5%) of the cases. When comparing the healthy and lung cancer groups, there is a highly significant difference at (P<0.01). Conclusion: Overexpression of RB, BRCA1, and BCL2 in lung cancers with little or no regulatory role may suggest mutational events, which act in collaboration with numerous other genetic mutations in these tissues. The study findings indicate that disruption of cell cycle proteins may perform a unique function in lung cancer disease onset and development and suggest that all patients have abnormalities in the BRCA1, BCL2, and RB proteins. have a role in lung carcinomas.

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Impact of Human Cytomegalovirus Infection associated with the expressed protein of mutated BRCA1 gene in breast tissues from a group of Iraqi Female Patients with Breast Carcinoma

Cited by 3 publications

References 0 publications

Detection of Cytomegalovirus in Urine Specimen of Cholestatic Infants by Polymerase Chain Reaction

Detection of Cytomegalovirus in Urine Specimen of Cholestatic Infants by Polymerase Chain Reaction

Prevalence of Human Cytomegalovirus in Breast Cancer: A Systematic Review

BRCA1, BCL2, and the RB Tumor Suppressor have abnormal expressions in lung cancer

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