Impact of <i><scp>H</scp>elicobacter pylori</i> Eradication on Circulating Adiponectin in Humans

Ando, Takashi; Ishikawa, Takeshi; Takagi, Tomohisa; Imamoto, Eiko; Kishimoto, Etsuko; Okajima, Akira; Uchiyama, Kazuhiko; Handa, Osamu; Yagi, Nobuaki; Kokura, Satoshi; Naito, Yuji; Mizuno, Shigeto; Asakawa, Akihiro; Inui, Akio; Yoshikawa, Toshikazu

doi:10.1111/hel.12028

Cited by 38 publications

(28 citation statements)

References 42 publications

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“…Paired liver biopsies are required to provide core evidence on histological endpoints, that is, hepatic steatosis, inflammation, and mainly fibrosis, regarded as the main histological endpoint for advanced disease . Importantly, total adiponectin and all its isoforms were increased after successful H pylori eradication treatment in humans, a finding that further supports the beginning of clinical trials, since adiponectin upregulation exhibits anti‐steatotic, anti‐inflammatory, anti‐fibrotic, and anti‐apoptotic effect in NAFLD . In this regard, thiazolidinediones (pioglitazone and rosiglitazone), which have shown beneficial effect on NAFLD histology, act at least partly through adiponectin upregulation .…”

Section: Closing Remarkssupporting

confidence: 53%

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Polyzos

2019

Helicobacter

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Section: Closing Remarkssupporting

confidence: 53%

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Polyzos

2019

Helicobacter

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“…Adiponectin, an adipocyte‐derived hormone, reduces lipid storage in the liver and protects against inflammation and fibrosis . Many studies suggested that patients with H. pylori infection have lower adiponectin levels, and H. pylori eradication can lead to an increase in adiponectin levels . Low serum adiponectin levels would contribute to the development of NAFLD .…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: A systematic review and meta‐analysis of observational studies

Zhou

Yang

et al. 2019

Helicobacter

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Background The association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD) has been shown in many observational studies, but these conclusions remain controversial. Hence, we performed a meta‐analysis to elucidate the association. Methods A comprehensive search was conducted on relevant studies published from inception to December 31, 2018, in PubMed, EMBASE, and Web of Science databases. Odds ratio (OR) with 95% confidence interval (95% CI) were pooled by random‐effect model, generic inverse variance method. Subgroup and sensitivity analyses were also done. Publication bias was estimated by the funnel plot, Begg's test, and Egger's test. Results Fifteen studies (eleven cross‐sectional, two case‐control, and two cohort studies) were included in this meta‐analysis. The pooled OR of NAFLD in patients with H. pylori infection was 1.19 (95% CI: 1.11‐1.29, P < 0.00001) when compared with the patients without H. pylori infection. Similar results were observed when the subgroup analyses were stratified by different geographical locations, study designs, and confounders adjustment. In subgroup analysis stratified by different H. pylori testing methods, the correlation still exists when using UBT, serology, RUT, or SAT, but there was no statistically significant difference when using multiple detection methods (OR = 2.96, 95% CI: 0.37‐23.94, P = 0.31). Sensitivity analyses showed that our results were robust. No evidence of substantial publication bias was detected. Conclusions Current evidence indicated that a positive association between H. pylori infection and the risk of NAFLD. Further prospective studies are warranted to strengthen the association and to clarify whether there is a causative link between them.

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“…Of these patients, 338 ones had HP and underwent treatment. The serum level of adiponectin had no statistically significant difference in HP positive and negative patients but HP eradication increased the adiponectin level [27]. …”

Section: Discussionmentioning

confidence: 99%

Serum Adiponectin Level in Diabetic Patients with and withoutHelicobacter pyloriInfection: Is There Any Difference?

Vafaeimanesh

Heidari

Effatpanah

et al. 2014

The Scientific World Journal

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Background. Increased insulin resistance is an extragastrointestinal manifestation of Helicobacter pylori (HP) infection. HP changes the level of inflammatory markers and cytokines and changes the adipocyte function by altering the adiponectin level. Given the high prevalence of HP and diabetes in our society, we evaluated the association between HP and serum adiponectin level. In this cross-sectional study, 211 diabetic patients under treatment other than insulin were studied. These patients were divided into two groups of HP+ and HP− based on their HP IgG antibody serology and their blood adiponectin levels were measured. Data was analyzed using independent t-test, Chi-square test, and Fisher's exact test. Results. Seventy-two patients with an average age of 51.56 ± 8.34 years were HP− and 139 patients with an average age of 50.35 ± 9.01 years were HP+. The mean serum adiponectin level in HP− and HP+ groups was 4.54 ± 5.43 and 5.64 ± 3.88 ng/mL, respectively. Insulin resistance degree was significantly higher in HP+ group (HP− = 3.160 ± 3.327 versus HP+ = 4.484 ± 3.781, P = 0.013) but no significant difference was found between the mean serum adiponectin level in HP− and HP+ groups (P = 0.140). Conclusions. Although the insulin resistance degree was significantly higher in HP+ diabetic patients, no significant relationship was found between HP infection and serum levels of adiponectin.

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Impact of Helicobacter pylori Eradication on Circulating Adiponectin in Humans

Abstract: Eradication therapy of H. pylori increased circulating adiponectin levels in Japanese individuals and could be beneficial for preventing metabolic syndrome conditions.

Cited by 38 publications

References 42 publications

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: A systematic review and meta‐analysis of observational studies

Serum Adiponectin Level in Diabetic Patients with and withoutHelicobacter pyloriInfection: Is There Any Difference?

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