We investigated the impact of land-cover changes on regional climate over the EuroMediterranean area. For this purpose, we compared a control simulation, which employs the presentday vegetation cover, with 2 different potential vegetation distributions performed with the regional climate model RegCM3 for the time period 1981-2000. The simulation results show how land-cover changes are able to modify both the thermodynamics and dynamics of the lower troposphere in central Europe, particularly during summer. Within some of the regions where land-cover change occurred, we found significant changes in heat fluxes, while weak changes were found in surface temperature and precipitation fields. Changes in vegetation composition modify the probability density function of the 2 m temperature, and hence land-cover changes may have a strong impact on extreme events.