Impaired fasting glucose and the prevalence and severity of angiographic coronary artery disease in high-risk Chinese patients

Dong, Xuehong; Zhou, Lei; Ying-jiu, Zhai; Lü, Bin; Wang, Dong; H, Shi; Luo, Xinping; Wei-hu, Fan; Hu, Renming

doi:10.1016/j.metabol.2007.08.004

Cited by 20 publications

(18 citation statements)

References 25 publications

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“…Progressive narrowing of the coronary arteries was observed in all 3 groups, from individuals with HbA1c levels <5.7%, to pre-diabetes at 5.7–6.4%, and diabetics with HbA1c ≥6.5%. This observation is in agreement with the findings of numerous studies, including a previous study by our group [25], where the increase in CHD was investigated pre-diabetic and diabetic individuals using glucose levels. As a marker of CHD, NT-proBNP showed the same trend which increased with regard to the severity or prevalence of CHD.…”

Section: Discussionsupporting

confidence: 93%

Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

et al. 2011

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BackgroundLittle is known about the plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), and the relationship between the severity of coronary heart disease (CHD) with NT-proBNP and multiple biomarkers in diabetic and pre-diabetic patients, compared to individuals with normal glucose levels.MethodsFour hundred and fifteen consecutive Chinese patients of both sexes were assigned to three groups on the basis of the new hemoglobin (Hb) A1c (HbA1c) cut-off points for diagnosis of diabetes and pre-diabetes. The three groups were divided into tertiles according to NT-proBNP, hs-CRP, cystatin C, and troponin T levels. Gensini scores were compared among the three groups and biomarker tertiles. Receiver operating characteristic (ROC) curves were used to obtain the angiographic CHD cut-off points for each biomarker. Stepwise multivariate linear correlation analysis was applied to examine the association between the severity of CHD and biomarker levels.ResultsGensini scores increased with increasing biomarker tertile levels and HbA1c. Gensini scores were significantly different in the middle and upper NT-proBNP tertiles of the diabetic, pre-diabetic and control groups. NT-proBNP had the highest positive and negative predictive values and area under the curve for CHD. Only NT-proBNP was identified as an independent variable for Gensini score.ConclusionsPlasma NT-proBNP may be an important biomarker to evaluate the severity of CHD and screen for CHD in diabetic or pre-diabetic patients.

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Section: Discussionsupporting

confidence: 93%

Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

et al. 2011

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“…In recent years, IGR has been repeatedly examined as a risk factor for cardiovascular morbidity and mortality [1][2][3][4][6][7][8][9], however, there are only few reports [5,[10][11][12][13] on the morphologic characteristics of coronary artery in patients with IGR, but with conflicting results. Seibaek et al and Horimoto et al [5,10] reported a lack of association between IGT and severity of stenosis.…”

Section: Discussionmentioning

confidence: 99%

Coronary angiographic studies of impaired glucose regulation and coronary artery disease in Chinese nondiabetic subjects

Yan

Hong

et al. 2009

Endocr

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To investigate the prevalence and the extent of coronary artery disease (CAD) in nondiabetic Chinese patients with different categories of impaired glucose regulation (IGR): isolated impaired fasting glucose (I-IFG); isolated impaired glucose tolerance (I-IGT); and combined IFG and IGT (CGI). A total of 556 nondiabetic subjects who had undergone coronary angiography were included in this study. Subjects were classified according to the 75-g oral glucose tolerance test result: normal glucose tolerance (NGT) (n = 278), I-IFG (n = 52), I-IGT (n = 128), CGI (n = 98). Significant CAD is defined as the presence of one or more coronary vessels with the lumeninal reduction in diameter to ≥50% in a given subject. The severity and extent of coronary atherosclerosis are defined by the Gensini score, the worst artery score, and the number of diseased vessels with significant coronary stenosis (number of diseased vessels). The prevalence of significant CAD in I-IFG and I-IGT groups were similar (67.3%, P = 0.207; 67.4%, P = 0.068, respectively) but both were higher comparing with NGT group (57.9%), however, it was considerably higher in CGI group (85.9%, P < 0.001). The Gensini score, worst artery score, and number of diseased vessels were similar in NGT, I-IFG, and I-IGT groups, but all significantly increased in CGI group after adjustment for other traditional factors (all P < 0.001). Logistic regression analyses reveal fasting glucose but not 2-h glucose as a significant determinant in Gensini score, worst artery score, and number of diseased vessels. The prevalence and the extent of CAD did not differ significantly among subjects with NGT, I-IFG, and I-IGT, but increased significantly in those with CGI. Fasting glucose was more strongly associated with angiographically characterized coronary artery stenosis than 2-h glucose.

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“…A recent survey reported a great disease burden of diabetes and prediabetes in China, with a prevalence of diabetes and prediabetes in 2010 of 11.6% and 50.1%, respectively . Results from a large cross‐sectional study including 0.5 million people aged 30–79 years showed that self‐reported diabetes and higher random blood glucose were associated with an increased risk of CVD and that FBG was associated with angiographic coronary heart disease (CHD) in a suspected myocardial ischemia population . One prospective study conducted in a Hong Kong Chinese population has identified HbA1c as a significant risk factor for stroke .…”

Section: Introductionmentioning

confidence: 99%

“…14 Results from a large cross-sectional study including 0.5 million people aged 30-79 years showed that self-reported diabetes and higher random blood glucose were associated with an increased risk of CVD 15 and that FBG was associated with angiographic coronary heart disease (CHD) in a suspected myocardial ischemia population. 16 One prospective study conducted in a Hong Kong Chinese population has identified HbA1c as a significant risk factor for stroke. 17 However, the generalizability of the results was limited by inclusion of only individuals with type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

Association of fasting glucose levels with incident atherosclerotic cardiovascular disease: An 8‐year follow‐up study in a Chinese population

Liu

Yang

et al. 2016

Journal of Diabetes

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Highlights• Diabetes other than impaired fasting glucose was associated with increased risk of incident ASCVD after 7.8 years follow-up among 18 610 participants.• Impaired fasting glucose increased the risk of developing diabetes.• Prevention strategy on reducing incidence of diabetes in persons with impaired fasting glucose is critical to improve cardiovascular health status. The association of diabetes with coronary heart disease was more pronounced than that with stroke. Gender and residential differences were also identified.Conclusions: In the present study, IFG was associated with the development of diabetes but not incident ASCVD. Prevention strategies to reduce the development of diabetes in people with IFG are critical to improve cardiovascular health.

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Impaired fasting glucose and the prevalence and severity of angiographic coronary artery disease in high-risk Chinese patients

Cited by 20 publications

References 25 publications

Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

Coronary angiographic studies of impaired glucose regulation and coronary artery disease in Chinese nondiabetic subjects

Association of fasting glucose levels with incident atherosclerotic cardiovascular disease: An 8‐year follow‐up study in a Chinese population

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