Implantable Drug Delivery

Nitsch, Monica J.; Banakar, Umesh V.

doi:10.1177/088532829400800305

Cited by 26 publications

(17 citation statements)

References 67 publications

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“…Drug delivery routes are normally four (Langer, 1991;Nitsch and Banakar, 1994): (a) oral, for pills and syrups; (b) rectal; (c) intramuscular or intravenous, for solutions ; 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 and (d) topic, as for eye drops. These conventional systems of drug delivery have a major disadvantage, which is that with time the concentration of the bioactive agent decreases to a minimum, leading to the need for a new dose of bioactive agent within a short time interval.…”

Section: Basic Concepts In Drug Deliverymentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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Section: Basic Concepts In Drug Deliverymentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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“…In this regard, various dosage forms or delivery systems including surgical implants and transdermal drug delivery systems have been investigated for prolonged drug release [6][7][8]. However, implantation of the aforementioned devices to a target site demands surgical intervention [9,10], thereby reducing patient compliance. Recently, in situ gel systems have received considerable attention since they are in liquid state (before administration) and can transform into a stiff gel (viscous) format upon injection to the body cavity.…”

Section: Introductionmentioning

confidence: 99%

Intrathecal Delivery of Ketorolac Loaded <i>In Situ</i> Gels for Prolonged Analgesic and Anti-Inflammatory Activity in Vertebral Fracture

Cao¹,

Chen²,

Tian³

et al. 2016

Trop. J. Pharm Res

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“…Numerous controlled release systems have been developed, ranging from implants [37,38] to novel osmotically driven pills [38]. The use of noninvasive delivery methods, such as injectable systems in the form of nano and microparticles, will bring substantial benefits when compared with some surgical techniques.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of starch-poly-ε-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications

et al. 2009

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One limitation associated with the delivery of bioactive agents concerns the short half-life of these molecules when administered intravenously, which results in their loss from the desired site. Incorporation of bioactive agents into depot vehicles provides a means to increase their persistence at the disease site. Major issues are involved in the development of a proper carrier system able to deliver the correct drug, at the desired dose, place and time. In this work, starch-poly-e-caprolactone (SPCL) microparticles were developed for use in drug delivery and tissue engineering (TE) applications. SPCL microparticles were prepared by using an emulsion solvent extraction/evaporation technique, which was demonstrated to be a successful procedure to obtain particles with a spherical shape (particle size between 5 and 900 lm) and exhibiting different surface morphologies. Their chemical structure was confirmed by Fourier transform infrared spectroscopy. To evaluate the potential of the developed microparticles as a drug delivery system, dexamethasone (DEX) was used as model drug. DEX, a well-known component of osteogenic differentiation media, was entrapped into SPCL microparticles at different percentages up to 93%. The encapsulation efficiency was found to be dependent on the polymer concentration and drug-to-polymer ratio. The initial DEX release seems to be governed mainly by diffusion, and it is expected that the remaining DEX will be released when the polymeric matrix starts to degrade. In this work it was demonstrated that SPCL microparticles containing DEX can be successfully prepared and that these microparticular systems seem to be quite promising for controlled release applications, namely as carriers of important differentiation agents in TE.

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Implantable Drug Delivery

Cited by 26 publications

References 67 publications

Materials in particulate form for tissue engineering. 1. Basic concepts

Materials in particulate form for tissue engineering. 1. Basic concepts

Intrathecal Delivery of Ketorolac Loaded <i>In Situ</i> Gels for Prolonged Analgesic and Anti-Inflammatory Activity in Vertebral Fracture

Preparation and characterization of starch-poly-ε-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications

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