The Coronavirus disease (Covid-19) has a very broad impact and continues to spoil all aspect of life and presents its challenges, especially in the world of education. All forms of conventional learning activities are replaced by distance learning which is known online. The application of online learning itself requires readiness for various parties, both from teachers, students, and parents. Educators must be able to teach by utilizing complex online media that are packaged effectively, easily accessible, and of course, make it easier for students to understand the material. Creativity in designing learning strategies is the key to the success of an educator to be able to motivate students to remain enthusiastic in distance learning and not become a psychological burden. This research method was carried out by conducting a literature review of 40 journals. The literature on effective learning strategies to support biology online learning. This research technique uses a literature analysis. The results of the analysis show that an effective online biology learning strategy to be used or applied while remaining student-centered is PjBL learning, and blended learning assisted by online platforms, such as elearning, and Google Classroom. The application of these learning strategies can also improve cognitive, creative learning outcomes, thinking skills, learning satisfaction, and students learning biology independence. The platforms that can support online biology learning are education perfect, Ruangguru, and zenius education