Vaccines can be understood as technological advances that aim to induce an immunological response through exposure to certain infectious agents, or specific particles thereof. The immunological response obtained creates memory and is capable of reducing the risk of developing diseases, as well as reducing mortality and complications in the event of an eventual infection. The general objective of this study aims to highlight how nurses' actions in the context of health education can help combat fake news related to vaccination. Fake news gained strength with the advent of social networks, and the spread of fake news increasingly threatens several achievements already achieved, including in the area of health. In this sense, there is an intimate relationship between the dissemination of fake news, the anti- vaccine movement and vaccine hesitancy. This is an investigation carried out through a review of scientific literature, which by definition has a qualitative- descriptive character. For its preparation, the findings of 21 works related to the proposed theme were selected, analyzed and summarized. The time frame covered the period from 2018 to 2023, that is, the last 6 years. Data were obtained through the following databases: Google Scholar, PubMed, VHL/Lilacs and Scopus. It was evident that the growing vaccine hesitancy may be associated with factors such as the population's distrust in relation to scientific information about immunization agents, related to the dissemination of fake news regarding the beneficial and adverse effects of vaccines. Above all, the strength of social networks in disseminating these untruths was demonstrated, and the need for public policy interventions and strategies to combat this misinformation.