2009
DOI: 10.1016/j.biomaterials.2009.05.034
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In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-β1 loaded fibrin–poly(lactide-caprolactone) nanoparticulate complex

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Cited by 72 publications
(55 citation statements)
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“…Finally, chondrogenic differentiation by ASCs in vivo cannot only be induced through their preinduction with TGF 1, but induced in vivo by using the scaffold itself. Enhanced synthesis of cartilaginous GAGs has been reported upon the subcutaneous implantation of ASCs seeded onto fibrin/poly(lactide-co-caprolactone) constructs loaded with TGF 1 nanoparticles [215]. In a similar vein, PLGA scaffolds, modified to slowly release plasmid DNA containing SOX-5,-6 and -9 for ASC transfection, has been found to increase the expression of collagen type II protein and decrease the expression of collagen type X when implanted into rabbit osteochondral defects [211].…”
Section: In Vivo Cartilagementioning
confidence: 99%
“…Finally, chondrogenic differentiation by ASCs in vivo cannot only be induced through their preinduction with TGF 1, but induced in vivo by using the scaffold itself. Enhanced synthesis of cartilaginous GAGs has been reported upon the subcutaneous implantation of ASCs seeded onto fibrin/poly(lactide-co-caprolactone) constructs loaded with TGF 1 nanoparticles [215]. In a similar vein, PLGA scaffolds, modified to slowly release plasmid DNA containing SOX-5,-6 and -9 for ASC transfection, has been found to increase the expression of collagen type II protein and decrease the expression of collagen type X when implanted into rabbit osteochondral defects [211].…”
Section: In Vivo Cartilagementioning
confidence: 99%
“…The absorbance was measured at 530 nm. All results are shown as means and standard deviations (n ¼ 3) (31).…”
Section: Measurement Of Glycosaminoglycan Levelsmentioning
confidence: 99%
“…To confirm the chondrogenic differentiation of the seeded cells, we performed polymerase chain reaction (PCR) analyses (31).…”
Section: Real-time Polymerase Chain Reaction and Reverse Transcriptiomentioning
confidence: 99%
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“…In addition, they effectively sustained chondrogenic differentiation and enhanced chondral extracellular matrix deposition by human adipogenic stem cells. Fibrin polylactide caprolactone nanoparticle complexes could be effectively used for in situ cartilage tissue regeneration from human stem cells (Jung et al, 2009). …”
Section: Nanoparticlesmentioning
confidence: 99%