In vitro and in vivo evaluation of β-cyclodextrin-based nanosponges of telmisartan

Rao, Monica R. P.; Bajaj, Amrita; Khole, Ishwar; Munjapara, Ghanshyam; Trotta, Francesco

doi:10.1007/s10847-012-0224-7

Cited by 89 publications

(38 citation statements)

References 10 publications

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“…The formation of a ternary complex of telmisartan with nanosponges and NaHCO 3 was seen to synergistically enhance the dissolution rate of telmisartan [47]. …”

Section: Reviewmentioning

confidence: 99%

Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

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303

219

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SummaryCyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.

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“…The formation of a ternary complex of telmisartan with nanosponges and NaHCO 3 was seen to synergistically enhance the dissolution rate of telmisartan [47]. …”

Section: Reviewmentioning

confidence: 99%

Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

Self Cite

303

219

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“…To analyze NS in solution (liquid medium), UV-Visible spectrophotometry is a fast, simple, valuable and economic tool. The solubilization efficacy of various molecules such as telmisartan (296 nm) [53], acetyl salicyclic acid (234 nm) [65], resveratrol (303 nm) [55], repaglinide (283 nm) [75], quercetin (372 nm) [76] and efavirenz (286 nm) [73] entrapped in NS have been analyzed using this tool.…”

Section: Ultraviolet: Visible Spectrophotometrymentioning

confidence: 99%

“…This tool explored the exothermic and endothermic processes at the temperature range from −120 to 600°C [85][86][87][88]. The thermal behavior of the various drugs (dexamethasone, furbiprofen, doxorubicin [80], Itraconazole [59], camptothecin [58], resverarol [55], amino salicylic acid [65], gamma-oryzanol [89], telmisartan [53], curcumin [54], acyclovir [37], quercetin [76] and meloxicam [64]) entrapped in the NS was examined by DSC.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

“…Crystalline and paracrystalline nature of NS and porosity can be revealed using this technique. A number of molecules (acetyl salicylic acid [65], camptothecin [58], telmisartan [53], resveratrol [55], acyclovir [37], quercetin [76], meloxicam [64], curcumin [54], and dexamethasone [82]) encapsulated in nanosponges have been evaluated using this technique.…”

Section: X-ray Diffraction Techniquesmentioning

confidence: 99%

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Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper crosslinked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.

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“…The molecular dimensions of GBP were investigated by molecular modeling studies using Schrodinger 2008 software which indicated partial entrapment of GBP in nanocavities of NSs. Previously similar studies were carried out to investigate the mode of entrapment of telmisartan into nanosponges 36 . NSs are highly efficient at entrapping different types of molecules (both hydrophilic and lipophilic) and they can achieve this due to the presence of many CD cavities.…”

Section: Saturation Solubility Studiesmentioning

confidence: 99%