In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes

Koroishi, Andrea Mayumi; Foss, Simone R.; Cortez, Diógenes Aparı́cio Garcia; Ueda-Nakamura, Tânia; Nakamura, Celso Vataru; Filho, Benedito Prado Dias

doi:10.1016/j.jep.2008.01.039

Cited by 70 publications

(46 citation statements)

References 23 publications

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“…The chemistry of the genus Piper has been widely investigated and the phytochemical investigations from all parts of the World have led to the isolation of a number of physiologically active compounds. A number of physiologically active compounds have been isolated from the Piper species: alkaloids/ amides, propenyl phenols, lignans, neolignans, terpenes, steroids, kawapyrones, piperolides, chalcones, dihydrochalcones, flavones and flavanones [5]. Piper capense is among the species of piper found in Ethiopia which is locally known as "abesha timiz" in a reference to its special shape The flavor of timiz (Piper Capense) is described as less strong in 'pepper taste' but with different aroma.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Arega¹

2018

J Pharmacogn Nat Prod

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Natural products have been a major source of drugs for centuries. The fruit of Piper capense is used traditionally as spice and for the treatment of infectious diseases in different parts of Ethiopia. The main objective of this work is to carry out phytochemical study of the EtOAc crude extract of the fruit of P. capense. Phytochemical screening on this crude extract revealed the presence of phenols, alkaloids, steroids, terpenes, saponins and flavonoids. After silica gel column chromatography the crude extract led to the isolation of compound PC1 identified as 5-Hydroxy-7, 4'-dimethoxyflavone. Characterization of this compound was achieved via spectroscopic methods (NMR, UV and IR). The structure of compound PC2 was elucidated, the spectral data showed the presence of more than one compound one of which is partially characterized and proposed to be rotenone.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Arega¹

2018

J Pharmacogn Nat Prod

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“…(Lima et al, 2006). Trichophyton, Microsporum and Epidermophyton have the ability to invade keratinized tissues, such as hair, skin or nails, of humans causing dermatophytosis including tinea corporis, tinea pedis and onychomycosis (Weitzman, Summerbell, 1995;Koroishi et al, 2008). Aspergillus flavus and A. parasiticus causes different clinical manifestations of human aspergillosis such as cutaneous aspergillosis, aspergillar otomycosis, aspergillar onychomycosis, invasive lung aspergillosis and aspergillar sinusitis (Dubey et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Souza

Lima

Guedes

et al. 2010

Braz. J. Pharm. Sci.

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“…A phytochemical study of Piper regnelli isolated phenylpropanoids and dihydrobenzofuran neolignans. Previous studies indicated the presence of (+)-conocarpan as a major compound, in addition to eupomatenoid-6, eupomatenoid-5, and eupomatenoid-3 (Koroishi et al, 2008;Luize et al, 2006;Pessini et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…Its leaves and roots are used in folk medicine in the form of crude extracts, infusions, and poultices for the treatment of wounds, swelling, and skin irritations (Yuncker, 1972). The extract and eupomatenoid-5, the neolignan isolated from the leaves of P. regnelli, have antimicrobial activity, including antibacterial (Pessini et al, 2003), antifungal (Koroishi et al, 2008), antileishmanial (Vendrametto et al, 2010), and trypanocidal (Luize et al, 2005) effects.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

Bertól¹,

Santos²,

Rodrigues³

et al. 2012

Rev. bras. farmacogn.

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This study investigated the antiviral potential of fractions and eupomatenoid-5 obtained from Piper regnelli (Miq.) C. DC., Piperaceae, leaves against bovine herpesvirus-1 (BHV-1) and poliovirus. VERO cell monolayers in 96-well cell culture plates were infected with BHV-1 or poliovirus and incubated in the presence and absence of samples for 48 h. The cells were then fixed and stained with sulforhodamine B, and the virus-induced cytopathic effect was measured in a 96-well plate reader at 530 nm. Cytotoxicity was assessed by incubating the cell monolayers with samples for 72 h. The hexane, chloroform, chloroform/ethyl acetate (19:1), and chloroform/ethyl acetate (9:1) fractions showed activity against BHV-1. The chloroform, chloroform/ethyl acetate (19:1), chloroform/ethyl acetate (9:1), chloroform/ethyl acetate (1:1), and ethyl acetate fractions were active against poliovirus. The chloroform/ethyl acetate (9:1) fraction presented the best selectivity index for both viruses. The present study reports the antiviral activity of the extract and fractions of P. regnelli leaves.

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In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes

Cited by 70 publications

References 23 publications

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

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