In Vitro Antioxidants, Antimicrobials and Biochemical Response of Methanol Leaf Extract of Eucalyptus camaldulensis following Sub-Acute Administration to Rats

Chiamaka, Onukogu Stella; Ndarubu, Tsado Amos; Mahmood, M; Adenike, Alawode Rahmatallah; Alfa, Suleiman; Praise, Ojo Olufunmilola; Musili, Oshevire Rejoice-Eyihuri; Mustapha, Aishatu; Lawal, Bashir

doi:10.36348/sjbr.2019.v04i11.007

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Systemic toxicity from nephrotoxicity can lead to a reduction in the body's capacity to eliminate waste products, an imbalance in bodily fluids and electrolytes, and a reduction in the production of vital hormones (Lawal et al, 2016). Consequently, urea, creatinine, and uric acid measurements are crucial for figuring out the kidney's synthetic and excretory functions (Onukogu et al, 2019;.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Sliver Nanoparticles Using Costus Afer Aqueous Leaf Extract and its Effect on Liver and Kidney Biomarkers in Adult Male Wistar Rat

B. O.,

Prisca A.,

E. T.

et al. 2023

Int. J. Res. Publ. Rev.

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Because nanotechnology has so many uses in waste management, solar energy, catalysis, and sensing, it is a field of study that is increasingly gaining attention from scientists. In the field of medicine, nanomaterials are effectively employed for wound healing, medication delivery, cardiovascular disease diagnostics and therapy, and the creation of antibacterial agents. The purpose of the current study was to assess how Costus afer-AgNPs extract affected male rats' liver indicators.There were eighteen adult male rats utilized in this experiment. Six groups of rats were randomly assigned. Throughout the experiment, the first group (control) ingested enough water and compressed food without any limitations. The Costus afer-AgNPs extract was taken daily by the second, third, fourth, fifth, and sixth experimental groups, who took 200, 400, 600, 800, and 1000 mg/kg body weight, respectively. Four weeks later, all groups had blood drawn under anesthesia.They separated the serum. ALP, ALT, and AST concentrations in the serum were determined, and uric acid, creatinine, and urea were examined. The LSD test, ANOVA, and SPSS were used to evaluate the gathered data. Results showed a significant increase in the mean serum urea and uric acid levels of rats but significantly brought back the markers to normal after treatment with an increasing dose of the extract. Serum levels of AST, ALP, and ALT significantly increased in the experimental groups receiving 200mg, 400mg, 600mg, 800mg and 1000mg Costus afer-AgNPs extract per kilogram body weight compared to the control group (P<0.05). Costus afer-AgNPs could be toxic upon consumption even at increasing doses.

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Section: Discussionmentioning

confidence: 99%

Green Synthesis of Sliver Nanoparticles Using Costus Afer Aqueous Leaf Extract and its Effect on Liver and Kidney Biomarkers in Adult Male Wistar Rat

B. O.,

Prisca A.,

E. T.

et al. 2023

Int. J. Res. Publ. Rev.

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Repurposing the drug, amprolium as a novel molluscicide against the land snail (Eobania vermiculata)

Mowafy,

Abdul-Hamid,

Moustafa

et al. 2024

Pesticide Biochemistry and Physiology

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Pharmacological activities of Azanza garckeana (Goron Tula) grown in Nigeria

Yusuf

Lawal

Sani³

et al. 2020

Clin Phytosci

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Background The present study evaluated the phytochemical profiles, anti-oxidants, antimicrobial, anti-inflammatory, analgesic, anti-arthritic and wound healing effect of methanol and ethyl-acetate extracts of Azanza garckeana. Results Methanol extract had higher phenol, flavonoids and alkaloids concentrations, ferric reducing antioxidant power (FRAP) and hydroxyl radical scavenging activities than ethyl-acetate extract. Ethyl-acetate and methanol extracts had IC50 of 119.40 μg/mL and 133.49 μg/mL respectively against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) radicals. The extracts were more active against Klebsiella pneumonia while the least activity was recoded against Bacillus subtilis with methanol been most potent than ethyl-acetate. The IC50 value of methanol extract in inhibition of protein denaturation were 310.44 μg/mL and 315.27 μg/mL while IC50 value of 354.74 μg/mL and 349.57 μg/mL were recorded for membrane stabilization effect in bovine serum albumin (BSA) and egg albumin (EGA) assays respectively. There was dose dependent in vivo anti-inflammatory and analgesic activities with highest percentage paw oedema inhibitions of 51.68% and analgesia of 46.36% at 600 mg/kg bw of the methanol extract. The extract caused dosed independent increase percentage wound closure with percentage wound contraction range between 65.24 ± 2.46 and 69.68 ± .2.54 compare to untreated wound (15.35 ± 0.35 to 50.35 ± 2.35%). Conclusion This study lends pharmacological support to folkloric usage of Azanza garckeana in the treatment and management of several human disease.

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In Vitro Antioxidants, Antimicrobials and Biochemical Response of Methanol Leaf Extract of Eucalyptus camaldulensis following Sub-Acute Administration to Rats

Cited by 4 publications

References 22 publications

Green Synthesis of Sliver Nanoparticles Using Costus Afer Aqueous Leaf Extract and its Effect on Liver and Kidney Biomarkers in Adult Male Wistar Rat

Green Synthesis of Sliver Nanoparticles Using Costus Afer Aqueous Leaf Extract and its Effect on Liver and Kidney Biomarkers in Adult Male Wistar Rat

Repurposing the drug, amprolium as a novel molluscicide against the land snail (Eobania vermiculata)

Pharmacological activities of Azanza garckeana (Goron Tula) grown in Nigeria

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