In vitro antitumor and anti-angiogenic activities of a shrimp chondroitin sulfate

Palhares, Lais C.G.F.; Barbosa, Jefferson Silva; Scortecci, Kátia Castanho; Rocha, Hugo Alexandre Oliveira; Brito, Adriana S.; Chavante, Suely F.

doi:10.1016/j.ijbiomac.2020.06.100

Cited by 15 publications

(8 citation statements)

References 82 publications

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“…Chondroitin sulfate (CS), a natural anionic glycoaminoglycan, is extracted from various marine animal cartilages, such as shark, skate and so on [ 13 , 14 ]. Studies showed CS exhibited a variety of biological activities, such as antioxidant activity [ 15 ], anti-inflammatory activity [ 16 ] and anti-tumor activity [ 17 ]. Since it is rich in carboxyl and hydroxyl groups, it is often used to stabilize SeNPs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

Chen

et al. 2022

Marine Drugs

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In the present study, a selenium-chondroitin sulfate (SeCS) was synthesized by the sodium selenite (Na2SeO3) and ascorbic acid (Vc) redox reaction using chondroitin sulfate derived from shark cartilage as a template, and characterized by SEM, SEM-EDS, FTIR and XRD. Meanwhile, its stability was investigated at different conditions of pH and temperatures. Besides, its antioxidant activity was further determined by the DPPH and ABTS assays. The results showed the SeCS with the smallest particle size of 131.3 ± 4.4 nm and selenium content of 33.18% was obtained under the optimal condition (CS concentration of 0.1 mg/mL, mass ratio of Na2SeO3 to Vc of 1:8, the reaction time of 3 h, and the reaction temperature of 25 °C). SEM image showed the SeCS was an individual and spherical nanostructure and its structure was evidenced by FTIR and XRD. Meanwhile, SeCS remained stable at an alkaline pH and possessed good storage stability at 4 °C for 28 days. The results on scavenging free radical levels showed that SeCS exhibited significantly higher antioxidant activity than SeNPs and CS, indicating that SeCS had a potential antioxidant effect.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

Chen

et al. 2022

Marine Drugs

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“…Furthermore, they effectively colonize the secondary organs, which is mainly due to their invasiveness. 60,61 The ndings also indicate that the combined use of ZJPs-II and G6G has an ability to weaken the invasiveness of the SW620 cells.…”

Section: Antioxidant Activity Of Zjps-ii G6g and Their Combination In Vitromentioning

confidence: 89%

New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities

Gao

Hong

et al. 2021

RSC Adv.

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“…After cell exposure to increasing EBHE concentrations (0.1, 1, 10, 100, and 1000 µL/mL) for 24 h at 37 °C, 10% of Alamar Blue ® reagent was added to each well, corresponding to a volume equivalent to a volume of culture medium. Cells were incubated again (4 h/37 °C/5% CO 2 ) before removing culture medium to add 100 μL of DMSO and assessing cell viability at 600 nm in a microplate ELISA reader [ 24 ] (Epoch-Biotek, Winooski, VT, USA). Cells grown in DMEM alone were used as a negative control.…”

Section: Methodsmentioning

confidence: 99%

Pseudobombax parvifolium Hydroalcoholic Bark Extract: Chemical Characterisation and Cytotoxic, Mutagenic, and Preclinical Aspects Associated with a Protective Effect on Oxidative Stress

et al. 2023

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Plants have long been used in traditional medicine to treat illnesses. Nevertheless, their chemical diversity requires studies to establish the extract dosage and its safe use. Pseudobombax parvifolium, an endemic species of the Brazilian Caatinga biome, is commonly used in folk medicine, due to its anti-inflammatory properties related to cellular oxidative stress; however, its biological properties have scarcely been studied. In this study, we chemically characterized the P. parvifolium hydroalcoholic bark extract (EBHE) and evaluated its cytotoxic, mutagenic, and preclinical aspects, as well as its antioxidant effect. Our phytochemical analysis revealed a significative total polyphenol content and identified loliolide for the first time in this species. Cytotoxicity, mutagenicity, and acute oral and repeated dose indicated no toxic effects on cell culture, Drosophila melanogaster, and Wistar rat exposure to different EBHE concentrations, respectively. Furthermore, we observed a significant decrease in lipid peroxidation and a mild hypoglycemic and hypolipidemic effect with repeated oral dosing of EBHE. Although there were no significant changes in glutathione content, we did observe a significant increase in superoxide dismutase at a dose of 400 mg/kg and in glutathione peroxidase at doses of 100, 200, and 400 mg/kg. These findings suggest that EBHE has potential as a source of bioactive molecules, and it can be used safely in traditional medicine and in the development of herbal medicines for application in the public health system.

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In vitro antitumor and anti-angiogenic activities of a shrimp chondroitin sulfate

Cited by 15 publications

References 82 publications

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities

Pseudobombax parvifolium Hydroalcoholic Bark Extract: Chemical Characterisation and Cytotoxic, Mutagenic, and Preclinical Aspects Associated with a Protective Effect on Oxidative Stress

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