In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs

Kay-Mugford, Patricia A; Benn, Sally J.; LaMarre, Jonathan; Conlon, Peter D.

doi:10.2460/ajvr.2000.61.802

Cited by 109 publications

(123 citation statements)

References 43 publications

(73 reference statements)

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“…Arterial blood pressure should be monitored and maintained within a normal range during anesthesia when carprofen or meloxicam are administered with butorphanol as premedication for dogs. Both clinical doses of carprofen and meloxicam provide effective postoperative analgesia when preoperatively administered [17][18][19], although meloxicam has higher in vitro selectivity of COX-2 inhibition than carprofen in dogs [5,15]. We also did not find any difference in sevofluranesparing effect between the treatments with carprofen alone and meloxicam alone, and between carprofen with butorphanol and meloxicam with butorphanol in dogs.…”

Section: Discussionmentioning

confidence: 46%

“…NSAIDs are classified depending on the activity of each isoform as nonselective COX inhibitors and COX-2 selective inhibitors [6]. Carprofen and meloxicam are COX-2 selective inhibitors that have been shown to produce analgesic effects with minimal side effect in dogs [5,6,15,34]. Their preoperative administration to dogs undergoing ovariohysterectomy has been reported to produce a greater analgesic effect in the early postoperative period than does postoperative administration [18,19].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

et al. 2008

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ABSTRACT. Sparing effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration (MAC) of sevoflurane were determined in 6 dogs. Anesthesia was induced and maintained with sevoflurane in oxygen, and MAC was determined by use of a tail clamp method. The dogs were administered a subcutaneous injection of carprofen (4 mg/kg) or meloxicam (0.2 mg/kg), or no medication (control) one hour prior to induction of anesthesia. Following the initial determination of MAC, butorphanol (0.3 mg/ kg) was administered intramuscularly, and MAC was determined again. The sevoflurane MACs for carprofen alone (2.10 ± 0.26%) and meloxicam alone (2.06 ± 0.20%) were significantly less than the control (2.39 ± 0.26%). The sevoflurane MACs for the combination of carprofen with butorphanol (1.78 ± 0.20%) and meloxicam with butorphanol (1.66 ± 0.29%) were also significantly less than the control value after the administration of butorphanol (2.12 ± 0.28%). The sevoflurane sparing effects of the combinations of carprofen with butorphanol and meloxicam with butorphanol were additive.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

et al. 2008

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“…In the present study, it has been hypothesized that NSAIDs which preferentially inhibit different COX isoenzymes (COX-1 or COX-2) can have various response to prevent probable postoperative and oxidative stress in dogs. Therefore, this study was designed to compare the effect of flunixin meglumine (FM), a nonselective inhibitor of COX-1 and COX-2 (Brideau et al 2001) and meloxicam (M), a selective COX-2 inhibitor (Kay-Mugford et al 2000) on cortisol, nitric oxide (NO), malondialdehyde (MDA), antioxidant potential (AOP) and glutation (GSH) concentrations in blood collected at different time intervals during and after the OHE.…”

Section: Introductionmentioning

confidence: 99%

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Yilmaz¹,

Korkmaz²,

Jaroszewski³

et al. 2014

Polish Journal of Veterinary Sciences

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The aim of this study was to compare the effect of flunixin meglumine (FM) and meloxicam (M) on postoperative and oxidative stress in ovariohysterectomized bitches. Twenty four bitches were divided into three groups (n=8 in each) and treated during premedication as follows: FM (2.2 mg/kg, iv, Fluvil, Vilsan, Turkey), M (0.2 mg/kg, sc, Maxicam, Sanovel, Turkey) or 0.9% saline (1 ml, iv, IE, Turkey) -control (C) group. The concentrations of serum cortisol, nitric oxide (NO), malondialdehyde (MDA), antioxidant potential (AOP) and glutation (GSH) were measured in blood samples collected during incision (0 h), closure of incision line (0.5 h) and 1, 2.5, 12 and 24 hours after incision. It was observed that cortisol level was higher at 0.5, 1 and 2.5 h in group C (p < 0.05), 0.5 h in group FM (p < 0.001), and 1 and 2.5 h in group M (p < 0.01), as compared to that determine at 0 h. Group C showed higher cortisol level during 0.5 h (p < 0.05) than that found in the other groups. Group FM displayed lower levels during 1 h (p < 0.01) and 2.5 h (p < 0.05) as compared to those observed in other groups. Concentrations of MDA, AOP and GSH between all the groups did not show any significant differences. MDA level was higher at 0.5 and 1 h in group M (p < 0.05) than that found in group C and it was the lowest at 2.5 h in group C (p < 0.05). AOP was higher at 2.5 h in group FM and M (p < 0.05) than that observed in group C, and at 12 and 24 h in group M than that found in group C and FM. GSH did not show any significant differences between the groups. NO level in group FM after 12 h was higher (p < 0.05) than that at 0.5, 1 and 24 h. Moreover, NO level was lower at 0.5 (p < 0.01), 1 (p < 0.05) and 24 h (p < 0.05) in group FM than that observed in group C and M. In conclusion, flunixin meglumine decreases cortisol and NO levels more efficiently than meloxicam. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine in bitches.

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“…Ketoprofen is a relatively selective COX-1 inhibitor [20,33,41]; adverse effects such as mild to moderate gastric mucosal injuries and renal hypofunction have been described [30,31]. On the other hand, meloxicam, an NSAID of the oxicam group, has a comparable analgesic effect to ketoprofen in dogs [5], and is also approved in Japan for the treatment of chronic inflammatory musculoskeletal conditions in dogs [32].…”

mentioning

confidence: 99%

“…On the other hand, meloxicam, an NSAID of the oxicam group, has a comparable analgesic effect to ketoprofen in dogs [5], and is also approved in Japan for the treatment of chronic inflammatory musculoskeletal conditions in dogs [32]. Meloxicam is a selective COX-2 inhibitor [20,33] and exhibits markedly reduced gastrointestinal tract adverse effects [10]. It is currently thought that the undesirable adverse effects of NSAIDs are due to inhibition of COX-1, especially in the gastrointestinal tract, and that inhibition of COX-2 is mainly responsible for pain control, due to its pathophysiological role in pain [37].…”

mentioning

confidence: 99%

The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Narita

Sato

Motoishi

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. The interaction between oral non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone administered concurrently for 30 days was studied in 18 healthy dogs divided into 3 groups of 6 dogs each: a drug-free negative control group (NC group) given 2 gelatin capsules; a group given meloxicam (0.1 mg/kg) and prednisolone (0.5 mg/kg) (MP group); and a group given a reduced dosage of ketoprofen (0.25 mg/kg, PO) and prednisolone (0.5 mg/kg, PO) (KP group). The dogs were periodically monitored by physical examinations, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests [effective renal plasma flow (ERPF) and glomerular filtration rate (GFR)], urinalyses [urinary sediments, and urinary micro-albumin to creatinine ratio (UAlb/Cre)], urinary enzyme indices, and haemostatic function tests [buccal mucosa bleeding time (BMBT), cuticle bleeding time (CBT)]. Significant changes were observed in the KP group, including a decrease of ERPF and GFR, an increased UAlb/Cre ratio, prolonged BMBT and CBT, as well as the presence of more severe grades of endoscopic lesions and fecal occult blood. In both the MP and KP groups, abnormal enzymuria with exfoliation of renal tubular epithelial cells in the urine was found. However, no significant changes in any of the other tests were observed in the MP group compared with the NC group. These findings suggest that the combination of NSAIDs, even selective COX-2 inhibitors, with prednisolone may be contraindicated due to the potential for serious adverse effects on the kidneys, the platelets, and the gastrointestinal tract.

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In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs

Cited by 109 publications

References 43 publications

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

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